Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms

Annals of Neurology

Volumn 70, Issue 6, 2011, Pages 943-954

  Zhang, Hua ^a   Bennett, Jeffrey L ^b   Verkman, A S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 4; COMPLEMENT; GAMMA INTERFERON; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN G; INTERLEUKIN 1BETA; INTERLEUKIN 6; MYELIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL STRUCTURE; CONTROLLED STUDY; DISEASE SEVERITY; EX VIVO STUDY; HIPPOCAMPUS; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; INFLAMMATORY CELL; MACROPHAGE; MICROGLIA; MOUSE; MYELOOPTIC NEUROPATHY; NATURAL KILLER CELL; NERVE CELL; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AQUAPORIN 4; CALCIUM-BINDING PROTEINS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN G; MICE; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; MYELIN BASIC PROTEINS; MYELIN SHEATH; NEUROMYELITIS OPTICA; OPTIC NERVE; ORGAN CULTURE TECHNIQUES; SPINAL CORD; TUBULIN;

EID: 84355166544     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.22551     Document Type: Article

References (33)

1. Wingerchuk DM, Lennon VA, Lucchinetti CF, et al. The spectrum of neuromyelitis optica. Lancet Neurol 2007; 6: 805-815. (Pubitemid 47238676)
2. Jarius S, Wildemann B,. AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance. Nat Rev Neurol 2010; 6: 383-392.
3. Lennon VA, Wingerchuk DM, Kryzer TJ, et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 2004; 364: 2106-2112. (Pubitemid 39626806)
4. Lennon VA, Kryzer TJ, Pittock SJ, et al. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 2005; 202: 473-477. (Pubitemid 41186945)
5. Lucchinetti CF, Mandler RN, McGavern D, et al. A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica. Brain 2002; 125: 1450-1461. (Pubitemid 34755161)
6. Misu T, Fujihara K, Kakita A, et al. Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis. Brain 2007; 130: 1224-1234. (Pubitemid 47355951)
7. Roemer SF, Parisi JE, Lennon VA, et al. Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis. Brain 2007; 130: 1194-1205. (Pubitemid 47355941)
8. Hinson SR, Pittock SJ, Lucchinetti CF, et al. Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica. Neurology 2007; 69: 2221-2231. (Pubitemid 350294677)
9. Takahashi T, Fujihara K, Nakashima I, et al. Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre. Brain 2007; 130: 1235-1243. (Pubitemid 47355956)
10. Jarius S, Aboul-Enein F, Waters P, et al. Antibody to aquaporin-4 in the long-term course of neuromyelitis optica. Brain 2008; 131: 3072-3080.
11. Cree BA, Lamb S, Morgan K, et al. An open label study of the effects of rituximab in neuromyelitis optica. Neurology 2005; 64: 1270-1272.
12. Miyamoto K, Kusunoki S,. Intermittent plasmapheresis prevents recurrence in neuromyelitis optica. Ther Apher Dial 2009; 13: 505-508.
13. Bennett JL, Lam C, Kalluri SR, et al. Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol 2009; 66: 617-629.
14. Bradl M, Misu T, Takahashi T, et al. Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo. Ann Neurol 2009; 66: 630-643.
15. Kinoshita M, Nakatsuji Y, Kimura T, et al. Neuromyelitis optica: passive transfer to rats by human immunoglobulin. Biochem Biophys Res Commun 2009; 386: 623-627.
16. Kinoshita M, Nakatsuji Y, Kimura T, et al. Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells. Biochem Biophys Res Commun 2010; 394: 205-210.
17. Saadoun S, Waters P, Bell BA, et al. Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Brain 2010; 133: 349-361.
18. Ma T, Yang B, Gillespie A, et al. Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest 1997; 100: 957-962. (Pubitemid 27386279)
19. Stoppini L, Buchs PA, Muller D,. A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 1991; 37: 173-182.
20. Uzawa A, Mori M, Arai K, et al. Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6. Mult Scler 2010; 16: 1443-1452.
21. Marignier R, Nicolle A, Watrin C, et al. Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury. Brain 2010; 133: 2578-2591.
22. Papadopoulos MC, Verkman AS,. Aquaporin-4 and brain edema. Pediatr Nephrol 2007; 22: 778-784. (Pubitemid 46629610)
23. Solenov EI, Vetrivel L, Oshio K, et al. Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice. J Neurosci Methods 2002; 113: 85-90. (Pubitemid 33123333)
24. Saadoun S, Papadopoulos MC, Watanabe H, et al. Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci 2005; 118: 5691-5698. (Pubitemid 43079263)
25. Binder DK, Yao X, Zador Z, et al. Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia 2006; 53: 631-636.
26. Li L, Zhang H, Varrin-Doyer M, et al. Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation. FASEB J 2011; 25: 1556-1566.
27. Yang B, Brown D, Verkman AS,. The mercurial insensitive water channel (AQP-4) forms orthogonal arrays in stably transfected Chinese hamster ovary cells. J Biol Chem 1996; 271: 4577-4580. (Pubitemid 26074929)
28. Dale DC, Boxer L, Liles WC,. The phagocytes: neutrophils and monocytes. Blood 2008; 112: 935-945.
29. Schlesinger LS, Horwitz MA,. Phagocytosis of Mycobacterium leprae by human monocyte-derived macrophages is mediated by complement receptors CR1 (CD35), CR3 (CD11b/CD18), and CR4 (CD11c/CD18) and IFN-gamma activation inhibits complement receptor function and phagocytosis of this bacterium. J Immunol 1991; 147: 1983-1994.
30. Rotshenker S,. Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease. J Mol Neurosci 2003; 21: 65-72. (Pubitemid 37204874)
31. Rogers CA, Gasque P, Piddlesden SJ, et al. Expression and function of membrane regulators of complement on rat astrocytes in culture. Immunology 1996; 88: 153-161. (Pubitemid 26166389)
32. Maranto J, Rappaport J, Datta PK,. Regulation of complement component C3 in astrocytes by IL-1beta and morphine. J Neuroimmune Pharmacol 2008; 3: 43-51.
33. Shimizu J, Hatanaka Y, Hasegawa M, et al. IFNβ-1b may severely exacerbate Japanese optic-spinal MS in neuromyelitis optica spectrum. Neurology 2010; 75: 1423-1427.