Hyperbranched PEGmethacrylate linear pDMAEMA block copolymer as an efficient non-viral gene delivery vector

International Journal of Pharmaceutics

Volumn 434, Issue 1-2, 2012, Pages 99-105

  Mathew, Asha ^a   Cao, Hongliang ^a   Collin, Estelle ^a   Wang, Wenxin ^a   Pandit, Abhay ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

2 (Dimethylamino) ethyl methacrylate; Deactivation enhanced atom transfer radical polymerisation; Gene therapy

Indexed keywords

COPOLYMER; DENDRIMER; PLASMID DNA; POLY(ETHYL METHACRYLATE); POLY[2 (DIMETHYLAMINO)ETHYL METHACRYLATE]; POLYETHYLENEIMINE; SUPERFECT; UNCLASSIFIED DRUG;

ADIPOSE DERIVED STEM CELL; ANIMAL CELL; ARTICLE; ATOM TRANSFER RADICAL POLYMERIZATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; FIBROBLAST; GENE VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL;

ADIPOSE TISSUE; ANIMALS; CELL SURVIVAL; DENDRIMERS; DNA; FIBROBLASTS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; METHACRYLATES; NYLONS; PLASMIDS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; RABBITS; STEM CELLS; TRANSFECTION;

EID: 84864152937     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.05.010     Document Type: Article

References (28)

1. B. Abdallah, L. Sachs, and B.A. Demeneix Non-viral gene transfer: applications in developmental biology and gene therapy Biol. Cell. 85 1995 1 7
2. H.V. Aposhian Use of DNA for gene therapy - need, experimental approach, and implications Perspect. Biol. Med. 14 1970 98 108
3. O. Boussif, F. Lezoualc'h, M.A. Zanta, M.D. Mergny, D. Scherman, B. Demeneix, and J.P. Behr A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine Proc. Natl. Acad. Sci. U.S.A. 92 1995 7297 7301
4. W.A. Braunecker, and K. Matyjaszewski Controlled/living radical polymerization: features, developments, and perspectives Prog. Polym. Sci. 32 2007 93 146
5. M. Breunig, U. Lungwitz, R. Liebl, and A. Goepferich Breaking up the correlation between efficacy and toxicity for nonviral gene delivery Proc. Natl. Acad. Sci. U.S.A. 104 2007 14454 14459
6. H. Cao, Y. Dong, S. O'Rorke, W. Wang, and A. Pandit PEG based hyperbranched polymeric hollow nanospheres Nanotechnology 22 2011 065604
7. K.S. Frederiksen, A. Petri, N. Abrahamsen, and H.S. Poulsen Gene therapy for lung cancer Lung Cancer 23 1999 191 207
8. A.M. Funhoff, S. Monge, R. Teeuwen, G.A. Koning, N.M. Schuurmans-Nieuwenbroek, D.J. Crommelin, D.M. Haddleton, W.E. Hennink, and C.F. van Nostrum PEG shielded polymeric double-layered micelles for gene delivery J. Control. Release 102 2005 711 724
9. A. Goto, and T. Fukuda Kinetics of living radical polymerization Prog. Polym. Sci. 29 2004 329 385
10. S. Goverdhana, M. Puntel, W. Xiong, J.M. Zirger, C. Barcia, J.F. Curtin, E.B. Soffer, S. Mondkar, G.D. King, J. Hu, S.A. Sciascia, M. Candolfi, D.S. Greengold, P.R. Lowenstein, and M.G. Castro Regulatable gene expression systems for gene therapy applications: progress and future challenges Mol. Ther. 12 2005 189 211
11. W.D. Henner, I. Kleber, and R. Benzinge Transfection of Escherichia-coli spheroplasts. III. Facilitation of transfection and stabilization of spheroplasts by different basic polymers J. Virol. 12 1973 741 747
12. K. Itaka, and K. Kataoka Recent development of nonviral gene delivery systems with virus-like structures and mechanisms Eur. J. Pharm. Biopharm. 71 2009 475 483
13. R.A. Jones, M.H. Poniris, and M.R. Wilson pDMAEMA is internalised by endocytosis but does not physically disrupt endosomes J. Control. Release 96 2004 379 391
14. P.W. Lee, S.F. Peng, C.J. Su, F.L. Mi, H.L. Chen, M.C. Wei, H.J. Lin, and H.W. Sung The use of biodegradable polymeric nanoparticles in combination with a low-pressure gene gun for transdermal DNA delivery Biomaterials 29 2008 742 751
15. S. Lin, F.S. Du, Y. Wang, S.P. Ji, D.H. Liang, L. Yu, and Z.C. Li An acid-labile block copolymer of PDMAEMA and PEG as potential carrier for intelligent gene delivery systems Biomacromolecules 9 2008 109 115
16. M.H. Maurer Proteomics of brain extracellular fluid (ECF) and cerebrospinal fluid (CSF) Mass Spectrom. Rev. 29 2010 17 28
17. J.V. Osterman, A. Waddell, and H.V. Aposhian Gene therapy systems - need, experimental approach, and implications Ann. N. Y. Acad. Sci. 179 1971 514 519
18. S. Rogers Gene therapy - potentially invaluable aid to medicine and mankind Res. Commun. Chem. Pathol. Pharmacol. 2 1971 587 600
19. G. Romano, P. Mitcheli, C. Pacilio, and A. Giordano Latest developments in gene transfer technology: achievements, perspectives, and controversies over therapeutic applications Stem Cells 18 2000 19 39
20. V.S. Trubetskoy, V.P. Torchilin, S.J. Kennel, and L. Huang Use of N-terminal modified poly(l-lysine)-antibody conjugate as a carrier for targeted gene delivery in mouse lung endothelial cells Bioconjugate Chem. 3 1992 323 327
21. M. Uchida, X.W. Li, P. Mertens, and H.O. Alpar Transfection by particle bombardment: delivery of plasmid DNA into mammalian cells using gene gun BBA: Gen. Subjects 1790 2009 754 764
22. L.E. van Vlerken, T.K. Vyas, and M.M. Amiji Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery Pharm. Res. 24 2007 1405 1414
23. I.M. Verma, and M.D. Weitzman Gene therapy: twenty-first century medicine Annu. Rev. Biochem. 74 2005 711 738
24. W. Wang, Y. Zheng, E. Roberts, C.J. Duxbury, L. Ding, D.J. Irvine, and S.M. Howdle Controlling chain growth: a new strategy to hyperbranched materials Macromolecules 40 2007 7184 7194
25. Y.H. Wang, M.L. Ho, J.K. Chang, H.C. Chu, S.C. Lai, and G.J. Wang Microporation is a valuable transfection method for gene expression in human adipose tissue-derived stem cells Mol. Ther. 17 2008 302 308
26. D. Wu, Y. Liu, X. Jiang, L. Chen, C. He, S.H. Goh, and K.W. Leong Evaluation of hyperbranched poly(amino ester)s of amine constitutions similar to polyethylenimine for DNA delivery Biomacromolecules 6 2005 3166 3173
27. L.S. Young, P.F. Searle, D. Onion, and V. Mautner Viral gene therapy strategies: from basic science to clinical application J. Pathol. 208 2006 299 318
28. L. Zhang, T.L.U. Nguyen, J. Bernard, T.P. Davis, C. Barner-Kowollik, and M.H. Stenzel Shell-cross-linked micelles containing cationic polymers synthesized via the RAFT process: toward a more biocompatible gene delivery system Biomacromolecules 8 2007 2890 2901