메뉴 건너뛰기




Volumn 18, Issue 3, 2013, Pages 293-306

The p38 MAPK PMK-1 shows heat-induced nuclear translocation, supports chaperone expression, and affects the heat tolerance of Caenorhabditis elegans

Author keywords

DAF 2; HSF 1; HSP; SKN 1; TOR

Indexed keywords

CHAPERONE; HEAT SHOCK TRANSCRIPTION FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN SKN 1; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 84877817019     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-012-0382-y     Document Type: Article
Times cited : (37)

References (52)
  • 1
    • 28044446334 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3
    • 16251270 10.1073/pnas.0508105102 1:CAS:528:DC%2BD2MXht1Cgur3F
    • An JH, Vranas K, Lucke M, Inoue H, Hisamoto N, Matsumoto K, Blackwell TK (2005) Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc Natl Acad Sci U S A 102(45):16275-16280
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.45 , pp. 16275-16280
    • An, J.H.1    Vranas, K.2    Lucke, M.3    Inoue, H.4    Hisamoto, N.5    Matsumoto, K.6    Blackwell, T.K.7
  • 2
    • 0030681260 scopus 로고    scopus 로고
    • The significance of digital gene expression profiles
    • 9331369 1:CAS:528:DyaK2sXntFahurc%3D
    • Audic S, Claverie JM (1997) The significance of digital gene expression profiles. Genome Res 7(10):986-995
    • (1997) Genome Res , vol.7 , Issue.10 , pp. 986-995
    • Audic, S.1    Claverie, J.M.2
  • 3
    • 0035197914 scopus 로고    scopus 로고
    • Isolation and characterization of pmk-(1-3): Three p38 homologs in Caenorhabditis elegans
    • 10.1006/mcbr.2001.0300 11703092 10.1006/mcbr.2001.0300 1:CAS:528:DC%2BD38XptVCm
    • Berman K, McKay J, Avery L, Cobb M (2001) Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans. Mol Cell Biol Res Commun 4(6):337-344. doi: 10.1006/mcbr.2001.0300
    • (2001) Mol Cell Biol Res Commun , vol.4 , Issue.6 , pp. 337-344
    • Berman, K.1    McKay, J.2    Avery, L.3    Cobb, M.4
  • 4
    • 1642569697 scopus 로고    scopus 로고
    • DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity
    • 10.1073/pnas.0304768101 15016915 10.1073/pnas.0304768101 1:CAS:528:DC%2BD2cXivFarsbY%3D
    • Boellmann F, Guettouche T, Guo Y, Fenna M, Mnayer L, Voellmy R (2004) DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity. Proc Natl Acad Sci U S A 101(12):4100-4105. doi: 10.1073/pnas.0304768101
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.12 , pp. 4100-4105
    • Boellmann, F.1    Guettouche, T.2    Guo, Y.3    Fenna, M.4    Mnayer, L.5    Voellmy, R.6
  • 5
    • 77951235254 scopus 로고    scopus 로고
    • A conserved PMK-1/p38 MAPK is required in Caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection
    • 20133945 10.1074/jbc.M109.091629 1:CAS:528:DC%2BC3cXjvFais78%3D
    • Bolz DD, Tenor JL, Aballay A (2010) A conserved PMK-1/p38 MAPK is required in Caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection. J Biol Chem 285(14):10832-10840
    • (2010) J Biol Chem , vol.285 , Issue.14 , pp. 10832-10840
    • Bolz, D.D.1    Tenor, J.L.2    Aballay, A.3
  • 7
    • 67650722550 scopus 로고    scopus 로고
    • Transformation and microinjection
    • doi: 10.1895/wormbook.1.108.1
    • Evans TC (2006) Transformation and microinjection. WormBook: 1-11. doi: 10.1895/wormbook.1.108.1
    • (2006) WormBook , pp. 1-11
    • Evans, T.C.1
  • 8
    • 0034924812 scopus 로고    scopus 로고
    • Folding of newly translated proteins in vivo: The role of molecular chaperones
    • 11395418 10.1146/annurev.biochem.70.1.603 1:CAS:528:DC%2BD3MXlsVehtLo%3D
    • Frydman J (2001) Folding of newly translated proteins in vivo: the role of molecular chaperones. Annu Rev Biochem 70:603-647
    • (2001) Annu Rev Biochem , vol.70 , pp. 603-647
    • Frydman, J.1
  • 9
    • 18244384703 scopus 로고    scopus 로고
    • Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress
    • 15760475 10.1186/1471-2091-6-4
    • Guettouche T, Boellmann F, Lane WS, Voellmy R (2005) Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem 6:4
    • (2005) BMC Biochem , vol.6 , pp. 4
    • Guettouche, T.1    Boellmann, F.2    Lane, W.S.3    Voellmy, R.4
  • 10
    • 0036110292 scopus 로고    scopus 로고
    • Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods
    • 10.1101/gr.228902 11997337 10.1101/gr.228902 1:CAS:528: DC%2BD38XjvFSgt7k%3D
    • GuhaThakurta D, Palomar L, Stormo GD, Tedesco P, Johnson TE, Walker DW, Lithgow G, Kim S, Link CD (2002) Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods. Genome Res 12(5):701-712. doi: 10.1101/gr.228902
    • (2002) Genome Res , vol.12 , Issue.5 , pp. 701-712
    • Guhathakurta, D.1    Palomar, L.2    Stormo, G.D.3    Tedesco, P.4    Johnson, T.E.5    Walker, D.W.6    Lithgow, G.7    Kim, S.8    Link, C.D.9
  • 11
    • 75949094261 scopus 로고    scopus 로고
    • A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation
    • 10.1016/j.molcel.2010.01.001 20159555 10.1016/j.molcel.2010.01.001 1:CAS:528:DC%2BC3cXlt1Kktbs%3D
    • Hageman J, Rujano MA, van Waarde MAWH, Kakkar V, Dirks RP, Govorukhina N, Oosterveld-Hut HMJ, Lubsen NH, Kampinga HH (2010) A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. Mol Cell 37(3):355-369. doi: 10.1016/j.molcel.2010.01.001
    • (2010) Mol Cell , vol.37 , Issue.3 , pp. 355-369
    • Hageman, J.1    Rujano, M.A.2    Van Waarde, M.3    Kakkar, V.4    Dirks, R.P.5    Govorukhina, N.6    Oosterveld-Hut, H.M.J.7    Lubsen, N.H.8    Kampinga, H.H.9
  • 12
    • 0035846604 scopus 로고    scopus 로고
    • Daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    • 11747825 10.1016/S0960-9822(01)00594-2 1:CAS:528:DC%2BD38XisFGk
    • Henderson ST, Johnson TE (2001) daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol 11(24):1975-1980
    • (2001) Curr Biol , vol.11 , Issue.24 , pp. 1975-1980
    • Henderson, S.T.1    Johnson, T.E.2
  • 13
    • 39849104918 scopus 로고    scopus 로고
    • Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in Caenorhabditis elegans
    • doi: 10.1186/1471-2199-9-9
    • Hoogewijs D, Houthoofd K, Matthijssens F, Vandesompele J, Vanfleteren JR (2008) Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in Caenorhabditis elegans. BMC Mol Biol 9:9. doi: 10.1186/1471-2199-9-9
    • (2008) BMC Mol Biol , vol.9 , pp. 9
    • Hoogewijs, D.1    Houthoofd, K.2    Matthijssens, F.3    Vandesompele, J.4    Vanfleteren, J.R.5
  • 14
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    • 10.1126/science.1083701 12750521 10.1126/science.1083701 1:CAS:528:DC%2BD3sXjslGqtr0%3D
    • Hsu AL, Murphy CT, Kenyon C (2003) Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300(5622):1142-1145. doi: 10.1126/science.1083701
    • (2003) Science , vol.300 , Issue.5622 , pp. 1142-1145
    • Hsu, A.L.1    Murphy, C.T.2    Kenyon, C.3
  • 16
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • 10.1038/nprot.2008.211 10.1038/nprot.2008.211 1:CAS:528: DC%2BD1cXhsFCkurnI
    • Huang DW, Sherman BT, Lempicki RA (2009a) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4(1):44-57. doi: 10.1038/nprot.2008.211
    • (2009) Nat Protoc , vol.4 , Issue.1 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 17
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • 10.1093/nar/gkn923 10.1093/nar/gkn923
    • Huang DW, Sherman BT, Lempicki RA (2009b) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37(1):1-13. doi: 10.1093/nar/gkn923
    • (2009) Nucleic Acids Res , vol.37 , Issue.1 , pp. 1-13
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 18
    • 25844490465 scopus 로고    scopus 로고
    • The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response
    • 16166371 10.1101/gad.1324805 1:CAS:528:DC%2BD2MXhtFais7%2FM
    • Inoue H, Hisamoto N, An JH, Oliveira RP, Nishida E, Blackwell TK, Matsumoto K (2005) The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev 19(19):2278-2283
    • (2005) Genes Dev , vol.19 , Issue.19 , pp. 2278-2283
    • Inoue, H.1    Hisamoto, N.2    An, J.H.3    Oliveira, R.P.4    Nishida, E.5    Blackwell, T.K.6    Matsumoto, K.7
  • 19
    • 79952434397 scopus 로고    scopus 로고
    • Co-regulation of the DAF-16 target gene, cyp-35B1/dod-13, by HSF-1 in C. elegans dauer larvae and daf-2 insulin pathway mutants
    • 10.1371/journal.pone.0017369 21408062 10.1371/journal.pone.0017369 1:CAS:528:DC%2BC3MXjslSmtr0%3D
    • Iser WB, Wilson MA, Wood WH 3rd, Becker K, Wolkow CA (2011) Co-regulation of the DAF-16 target gene, cyp-35B1/dod-13, by HSF-1 in C. elegans dauer larvae and daf-2 insulin pathway mutants. PLoS One 6(3):e17369. doi: 10.1371/journal.pone.0017369
    • (2011) PLoS One , vol.6 , Issue.3 , pp. 17369
    • Iser, W.B.1    Wilson, M.A.2    Wood III, W.H.3    Becker, K.4    Wolkow, C.A.5
  • 20
    • 4544311861 scopus 로고    scopus 로고
    • The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
    • 10.1242/dev.01255 15253933 10.1242/dev.01255 1:CAS:528: DC%2BD2cXns1SntLc%3D
    • Jia K, Chen D, Riddle DL (2004) The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131(16):3897-3906. doi: 10.1242/dev.01255
    • (2004) Development , vol.131 , Issue.16 , pp. 3897-3906
    • Jia, K.1    Chen, D.2    Riddle, D.L.3
  • 21
    • 38149092669 scopus 로고    scopus 로고
    • Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans
    • 17714076 10.1042/BJ20070521 1:CAS:528:DC%2BD2sXhsVantb3K
    • Kahn NW, Rea SL, Moyle S, Kell A, Johnson TE (2008) Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans. Biochem J 409(1):205-213
    • (2008) Biochem J , vol.409 , Issue.1 , pp. 205-213
    • Kahn, N.W.1    Rea, S.L.2    Moyle, S.3    Kell, A.4    Johnson, T.E.5
  • 22
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • 10.1038/366461a0 8247153 10.1038/366461a0 1:STN:280: DyaK2c%2FmslensQ%3D%3D
    • Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993) A C. elegans mutant that lives twice as long as wild type. Nature 366(6454):461-464. doi: 10.1038/366461a0
    • (1993) Nature , vol.366 , Issue.6454 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.5
  • 24
    • 18844424923 scopus 로고    scopus 로고
    • The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei
    • 15888317 10.1016/j.mad.2004.11.012 1:CAS:528:DC%2BD2MXktVKqsL0%3D
    • Kondo M, Yanase S, Ishii T, Hartman PS, Matsumoto K, Ishii N (2005) The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei. Mech Ageing Dev 126(6-7):642-647
    • (2005) Mech Ageing Dev , vol.126 , Issue.6-7 , pp. 642-647
    • Kondo, M.1    Yanase, S.2    Ishii, T.3    Hartman, P.S.4    Matsumoto, K.5    Ishii, N.6
  • 25
    • 0025274443 scopus 로고
    • The Caenorhabditis elegans rol-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen
    • 1970117 1:CAS:528:DyaK3cXls1Kgurc%3D
    • Kramer JM, French RP, Park EC, Johnson JJ (1990) The Caenorhabditis elegans rol-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen. Mol Cell Biol 10(5):2081-2089
    • (1990) Mol Cell Biol , vol.10 , Issue.5 , pp. 2081-2089
    • Kramer, J.M.1    French, R.P.2    Park, E.C.3    Johnson, J.J.4
  • 26
    • 0036049583 scopus 로고    scopus 로고
    • Function and regulation of cytosolic molecular chaperone CCT
    • 12481552 10.1016/S0083-6729(02)65069-1 1:CAS:528:DC%2BD3sXhtVWiu74%3D
    • Kubota H (2002) Function and regulation of cytosolic molecular chaperone CCT. Vitam Horm 65:313-331
    • (2002) Vitam Horm , vol.65 , pp. 313-331
    • Kubota, H.1
  • 27
    • 0141454834 scopus 로고    scopus 로고
    • Evolution of the cellular stress proteome: From monophyletic origin to ubiquitous function
    • 12909693 10.1242/jeb.00549
    • Kültz D (2003) Evolution of the cellular stress proteome: from monophyletic origin to ubiquitous function. J Exp Biol 206:3119-3124
    • (2003) J Exp Biol , vol.206 , pp. 3119-3124
    • Kültz, D.1
  • 28
    • 15544377794 scopus 로고    scopus 로고
    • Molecular and evolutional basis of the cellular stress response
    • 10.1146/annurev.physiol.67.040403.103635 15709958 10.1146/annurev. physiol.67.040403.103635
    • Kültz D (2005) Molecular and evolutional basis of the cellular stress response. Annu Rev Physiol 67:225-257. doi: 10.1146/annurev.physiol.67. 040403.103635
    • (2005) Annu Rev Physiol , vol.67 , pp. 225-257
    • Kültz, D.1
  • 30
    • 0034967720 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    • 10.1038/88850 11381260 10.1038/88850 1:CAS:528:DC%2BD3MXktFOrtLo%3D
    • Lin K, Hsin H, Libina N, Kenyon C (2001) Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet 28(2):139-145. doi: 10.1038/88850
    • (2001) Nat Genet , vol.28 , Issue.2 , pp. 139-145
    • Lin, K.1    Hsin, H.2    Libina, N.3    Kenyon, C.4
  • 31
    • 0027945612 scopus 로고
    • Thermotolerance of a long-lived mutant of Caenorhabditis elegans
    • 7963273 10.1093/geronj/49.6.B270 1:STN:280:DyaK2M%2Flt1ehuw%3D%3D
    • Lithgow GJ, White TM, Hinerfeld DA, Johnson TE (1994) Thermotolerance of a long-lived mutant of Caenorhabditis elegans. J Gerontol 49(6):B270-B276
    • (1994) J Gerontol , vol.49 , Issue.6
    • Lithgow, G.J.1    White, T.M.2    Hinerfeld, D.A.3    Johnson, T.E.4
  • 32
    • 0042631524 scopus 로고    scopus 로고
    • Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16
    • 10.1046/j.1474-9728.2003.00043.x 12882324 10.1046/j.1474-9728.2003.00043. x 1:CAS:528:DC%2BD3sXkt1Kqsb8%3D
    • McElwee JJ, Bubb K, Thomas JH (2003) Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2(2):111-121. doi: 10.1046/j.1474-9728.2003.00043.x
    • (2003) Aging Cell , vol.2 , Issue.2 , pp. 111-121
    • McElwee, J.J.1    Bubb, K.2    Thomas, J.H.3
  • 33
    • 0025942107 scopus 로고
    • Efficient gene transfer in C. elegans: Extrachromosomal maintenance and integration of transforming sequences
    • 1935914 1:CAS:528:DyaK38XhsVOm
    • Mello CC, Kramer JM, Stinchcomb D, Ambros V (1991) Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J 10(12):3959-3970
    • (1991) EMBO J , vol.10 , Issue.12 , pp. 3959-3970
    • Mello, C.C.1    Kramer, J.M.2    Stinchcomb, D.3    Ambros, V.4
  • 34
    • 3042685022 scopus 로고    scopus 로고
    • The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response
    • 10.1038/sj.emboj.7600226 15116070 10.1038/sj.emboj.7600226 1:CAS:528:DC%2BD2cXksV2hsbo%3D
    • Mizuno T, Hisamoto N, Terada T, Kondo T, Adachi M, Nishida E, Kim DH, Ausubel FM, Matsumoto K (2004) The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. EMBO J 23(11):2226-2234. doi: 10.1038/sj.emboj.7600226
    • (2004) EMBO J , vol.23 , Issue.11 , pp. 2226-2234
    • Mizuno, T.1    Hisamoto, N.2    Terada, T.3    Kondo, T.4    Adachi, M.5    Nishida, E.6    Kim, D.H.7    Ausubel, F.M.8    Matsumoto, K.9
  • 35
    • 0032535245 scopus 로고    scopus 로고
    • Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators
    • 9869631 10.1101/gad.12.24.3788 1:CAS:528:DyaK1MXmtFGjsQ%3D%3D
    • Morimoto RI (1998) Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev 12(24):3788-3796
    • (1998) Genes Dev , vol.12 , Issue.24 , pp. 3788-3796
    • Morimoto, R.I.1
  • 36
    • 46249106990 scopus 로고    scopus 로고
    • Mapping and quantifying mammalian transcriptomes by RNA-Seq
    • 18516045 10.1038/nmeth.1226 1:CAS:528:DC%2BD1cXnslyqs7k%3D
    • Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B (2008) Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 5(7):621-628
    • (2008) Nat Methods , vol.5 , Issue.7 , pp. 621-628
    • Mortazavi, A.1    Williams, B.A.2    McCue, K.3    Schaeffer, L.4    Wold, B.5
  • 37
    • 33751430460 scopus 로고    scopus 로고
    • The search for DAF-16/FOXO transcriptional targets: Approaches and discoveries
    • 16934425 10.1016/j.exger.2006.06.040 1:CAS:528:DC%2BD28Xht1KrsLvL
    • Murphy CT (2006) The search for DAF-16/FOXO transcriptional targets: approaches and discoveries. Exp Gerontol 41(10):910-921
    • (2006) Exp Gerontol , vol.41 , Issue.10 , pp. 910-921
    • Murphy, C.T.1
  • 38
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • 10.1038/nature01789 12845331 10.1038/nature01789 1:CAS:528: DC%2BD3sXlsVGjs7Y%3D
    • Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C (2003) Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424(6946):277-283. doi: 10.1038/nature01789
    • (2003) Nature , vol.424 , Issue.6946 , pp. 277-283
    • Murphy, C.T.1    McCarroll, S.A.2    Bargmann, C.I.3    Fraser, A.4    Kamath, R.S.5    Ahringer, J.6    Li, H.7    Kenyon, C.8
  • 39
    • 0023087430 scopus 로고
    • Effect of heat shock on protein degradation in mammalian cells: Involvement of the ubiquitin system
    • 3034579 1:CAS:528:DyaL2sXhtFOhs7Y%3D
    • Parag HA, Raboy B, Kulka RG (1987) Effect of heat shock on protein degradation in mammalian cells: involvement of the ubiquitin system. EMBO J 6(1):55-61
    • (1987) EMBO J , vol.6 , Issue.1 , pp. 55-61
    • Parag, H.A.1    Raboy, B.2    Kulka, R.G.3
  • 40
    • 0028935270 scopus 로고
    • Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    • 7535770 10.1074/jbc.270.13.7420 1:CAS:528:DyaK2MXkvVOjs7c%3D
    • Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ, Davis RJ (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 270(13):7420-7426
    • (1995) J Biol Chem , vol.270 , Issue.13 , pp. 7420-7426
    • Raingeaud, J.1    Gupta, S.2    Rogers, J.S.3    Dickens, M.4    Han, J.5    Ulevitch, R.J.6    Davis, R.J.7
  • 41
    • 78649346692 scopus 로고    scopus 로고
    • The heat shock response: Life on the verge of death
    • 20965420 10.1016/j.molcel.2010.10.006 1:CAS:528:DC%2BC3cXhtlCjtr7E
    • Richter K, Haslbeck M, Buchner J (2010) The heat shock response: life on the verge of death. Mol Cell 40(2):253-266
    • (2010) Mol Cell , vol.40 , Issue.2 , pp. 253-266
    • Richter, K.1    Haslbeck, M.2    Buchner, J.3
  • 42
    • 0035917475 scopus 로고    scopus 로고
    • The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling decision required for asymmetric olfactory neuron fates
    • 11336672 10.1016/S0092-8674(01)00313-0 1:CAS:528:DC%2BD3MXjtFOkt7c%3D
    • Sagasti A, Hisamoto N, Hyodo J, Tanaka-Hino M, Matsumoto K, Bargmann CI (2001) The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling decision required for asymmetric olfactory neuron fates. Cell 105(2):221-232
    • (2001) Cell , vol.105 , Issue.2 , pp. 221-232
    • Sagasti, A.1    Hisamoto, N.2    Hyodo, J.3    Tanaka-Hino, M.4    Matsumoto, K.5    Bargmann, C.I.6
  • 43
    • 3843054458 scopus 로고    scopus 로고
    • Roles of MAP kinase cascades in Caenorhabditis elegans
    • 10.1093/jb/mvh097 15269234 10.1093/jb/mvh097 1:CAS:528: DC%2BD2cXnsFWku7Y%3D
    • Sakaguchi A, Matsumoto K, Hisamoto N (2004) Roles of MAP kinase cascades in Caenorhabditis elegans. J Biochem 136(1):7-11. doi: 10.1093/jb/mvh097
    • (2004) J Biochem , vol.136 , Issue.1 , pp. 7-11
    • Sakaguchi, A.1    Matsumoto, K.2    Hisamoto, N.3
  • 44
    • 50349093357 scopus 로고    scopus 로고
    • Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs
    • 18482985 10.1074/jbc.M801074200 1:CAS:528:DC%2BD1cXotF2ksbo%3D
    • Sheridan DL, Kong Y, Parker SA, Dalby KN, Turk BE (2008) Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs. J Biol Chem 283(28):19511-19520
    • (2008) J Biol Chem , vol.283 , Issue.28 , pp. 19511-19520
    • Sheridan, D.L.1    Kong, Y.2    Parker, S.A.3    Dalby, K.N.4    Turk, B.E.5
  • 45
    • 77952376722 scopus 로고    scopus 로고
    • Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans
    • 10.1371/journal.pgen.1000892 20369020 10.1371/journal.pgen.1000892
    • Shivers RP, Pagano DJ, Kooistra T, Richardson CE, Reddy KC, Whitney JK, Kamanzi O, Matsumoto K, Hisamoto N, Kim DH (2010) Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans. PLoS Genet 6(4):e1000892. doi: 10.1371/journal.pgen. 1000892
    • (2010) PLoS Genet , vol.6 , Issue.4 , pp. 1000892
    • Shivers, R.P.1    Pagano, D.J.2    Kooistra, T.3    Richardson, C.E.4    Reddy, K.C.5    Whitney, J.K.6    Kamanzi, O.7    Matsumoto, K.8    Hisamoto, N.9    Kim, D.H.10
  • 46
    • 38449085292 scopus 로고    scopus 로고
    • Maintenance of C. elegans
    • doi: 10.1895/wormbook.1.101.1
    • Stiernagle T (2006) Maintenance of C. elegans. WormBook:1-11. doi: 10.1895/wormbook.1.101.1
    • (2006) WormBook , pp. 1-11
    • Stiernagle, T.1
  • 47
    • 0036171872 scopus 로고    scopus 로고
    • SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans
    • 10.1093/embo-reports/kvf001 11751572 10.1093/embo-reports/kvf001 1:CAS:528:DC%2BD38Xht1Smtrc%3D
    • Tanaka-Hino M, Sagasti A, Hisamoto N, Kawasaki M, Nakano S, Ninomiya-Tsuji J, Bargmann CI, Matsumoto K (2002) SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans. EMBO Rep 3(1):56-62. doi: 10.1093/embo-reports/kvf001
    • (2002) EMBO Rep , vol.3 , Issue.1 , pp. 56-62
    • Tanaka-Hino, M.1    Sagasti, A.2    Hisamoto, N.3    Kawasaki, M.4    Nakano, S.5    Ninomiya-Tsuji, J.6    Bargmann, C.I.7    Matsumoto, K.8
  • 48
    • 33751382748 scopus 로고    scopus 로고
    • P38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans
    • 17096597 10.1371/journal.pgen.0020183
    • Troemel ER, Chu SW, Reinke V, Lee SS, Ausubel FM, Kim DH (2006) p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet 2(11):e183
    • (2006) PLoS Genet , vol.2 , Issue.11 , pp. 183
    • Troemel, E.R.1    Chu, S.W.2    Reinke, V.3    Lee, S.S.4    Ausubel, F.M.5    Kim, D.H.6
  • 49
    • 40949114546 scopus 로고    scopus 로고
    • Cadmium-induced germline apoptosis in Caenorhabditis elegans: The roles of HUS1, p53, and MAPK signaling pathways
    • 17728284 10.1093/toxsci/kfm220 1:CAS:528:DC%2BD1cXjtFOntLo%3D
    • Wang S, Tang M, Pei B, Xiao X, Wang J, Hang H, Wu L (2008) Cadmium-induced germline apoptosis in Caenorhabditis elegans: the roles of HUS1, p53, and MAPK signaling pathways. Toxicol Sci 102(2):345-351
    • (2008) Toxicol Sci , vol.102 , Issue.2 , pp. 345-351
    • Wang, S.1    Tang, M.2    Pei, B.3    Xiao, X.4    Wang, J.5    Hang, H.6    Wu, L.7
  • 51
    • 38449093926 scopus 로고    scopus 로고
    • The MAP kinase JNK-1 of Caenorhabditis elegans: Location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness
    • 10.1002/jcp.21269 17894411 10.1002/jcp.21269 1:CAS:528: DC%2BD1cXhvVSlsbo%3D
    • Wolf M, Nunes F, Henkel A, Heinick A, Paul RJ (2008) The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness. J Cell Physiol 214(3):721-729. doi: 10.1002/jcp.21269
    • (2008) J Cell Physiol , vol.214 , Issue.3 , pp. 721-729
    • Wolf, M.1    Nunes, F.2    Henkel, A.3    Heinick, A.4    Paul, R.J.5
  • 52
    • 70249090092 scopus 로고    scopus 로고
    • Nuclear localization of p38 MAPK in response to DNA damage
    • 19564926 10.7150/ijbs.5.428 1:CAS:528:DC%2BD1MXnsl2qsro%3D
    • Wood CD, Thornton TM, Sabio G, Davis RA, Rincon M (2009) Nuclear localization of p38 MAPK in response to DNA damage. Int J Biol Sci 5(5):428-437
    • (2009) Int J Biol Sci , vol.5 , Issue.5 , pp. 428-437
    • Wood, C.D.1    Thornton, T.M.2    Sabio, G.3    Davis, R.A.4    Rincon, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.