Human airway trypsin-like protease induces mucin5AC hypersecretion via a protease-activated receptor 2-mediated pathway in human airway epithelial cells

Archives of Biochemistry and Biophysics

Volumn 535, Issue 2, 2013, Pages 234-240

  Liu, Chunyi ^a   Li, Qi ^a   Zhou, Xiangdong ^a   Kolosov, Victor P ^b   Perelman, Juliy M ^b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b Russian Academy of Medical Sciences   (Russian Federation)

Author keywords

G q 11 protein; Human airway trypsin like protease; Intracellular calcium; Mucin5AC; Phospholipase C; Protease activated receptor 2

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; G ALPHA PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HUMAN AIRWAY TRYPSIN LIKE PROTEASE; MESSENGER RNA; MUCIN 5AC; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE INHIBITOR; SERINE PROTEINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; YM 254890;

ARTICLE; ATTENUATION; BRONCHIAL EPITHELIAL CELL; BRONCHUS MUCOSA; CONTROLLED STUDY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; EXOCYTOSIS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MEDIATOR; MUCUS SECRETION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

CALCIUM; CELLS, CULTURED; EPITHELIAL CELLS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; MUCIN 5AC; RECEPTOR, PAR-2; RESPIRATORY MUCOSA; RNA, MESSENGER; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION;

EID: 84877809808     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2013.02.013     Document Type: Article

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