Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 31, Issue 4, 2004, Pages 446-455

  Kemp, Philip A ^a   Sugar, Rosemary A ^a   Jackson, Alan D ^a,b  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b Novartis Institutes for Biomedical Research   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE 5' O (3 THIOTRIPHOSPHATE); ADENOSINE TRIPHOSPHATE; AR C118925XX; CALPHOSTIN C; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; IONOMYCIN; MUCIN; PERTUSSIS TOXIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C; PHOSPHOLIPASE C INHIBITOR; PROTEIN INHIBITOR; PROTEIN KINASE C; PURINE P2Y2 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; SURAMIN; THAPSIGARGIN; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE;

ARTICLE; BRONCHUS MUCOSA; CELL DIFFERENTIATION; COMPARTMENT MODEL; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; HUMAN; HUMAN CELL; MUCUS SECRETION; REGULATORY MECHANISM; SIGNAL NOISE RATIO;

ADENOSINE TRIPHOSPHATE; BINDING, COMPETITIVE; BRONCHI; CALCIUM; CARCINOGENS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CHELATING AGENTS; EPITHELIAL CELLS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; LECTINS; MUCINS; NAPHTHALENES; PERTUSSIS TOXIN; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION; SURAMIN; TETRADECANOYLPHORBOL ACETATE; URIDINE TRIPHOSPHATE;

BRONCHUS;

EID: 4944230996     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2003-0211OC     Document Type: Article

References (40)

1. Prescott, E. I., P. Lange, and J. Vestbo. 1996. Chronic expectoration and risk of death in chronic obstructive lung disease. Ugeskr. Laeger 158:6456-6460.
2. Aikawa, T., S. Shimura, H. Sasaki, T. Takishima, H. Yaegashi, and T. Takahashi. 1989. Morphometric analysis of intraluminal mucus in airways in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 140:477-482.
3. Aikawa, T., S. Shimura, H. Sasaki, M. Ebina, and T. Takishima. 1992. Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack. Chest 101:916-921.
4. 1 decline and chronic obstructive pulmonary disease morbidity. Am. J. Respir. Crit. Care Med. 153:1530-1535.
5. Lange, P., J. Vestbo, and J. Nyboe. 1995. Risk factors for death and hospitalization from pneumonia: a prospective study of a general population. Eur. Respir. J. 8:1694-1698.
6. Agusti, C., K. Takeyama, L. O. Cardell, I. Ueki, J. Lausier, Y. P. Lou, and J. A. Nadel. 1998. Goblet cell degranulation after antigen challenge in sensitized guinea pigs: role of neutrophils. Am. J. Respir. Crit. Care Med. 158:1253-1258.
7. Gouyer, V., A. Wiede, M. P. Buisine, S. Dekeyser, O. Moreau, T. Lesuffleur, W. Hoffmann, and G. Huet. 2001. Specific secretion of gel-forming mucins and TFF peptides in HT-29 cells of mucin-secreting phenotype. Biochim. Biophys. Acta 1539:71-84.
8. Scott, C. E., L. H. Abdullah, and C. W. Davis. 1998. Ca2+ and protein kinase C activation of mucin granule exocytosis in permeabilized SPOC1 cells. Am. J. Physiol. 275:C285-C292.
9. Abdullah, L. H., S. W. Davis, L. Burch, M. Yamauchi, S. H. Randell, P. Nettesheim, and C. W. Davis. 1996. P2u purinoceptor regulation of mucin secretion in SPOC1 cells, a goblet cell line from the airways. Biochem. J. 316:943-951.
10. Kim, K. C, G. J. Gleich, and M. K. Lee. 1999. Two eosinophil granule proteins, eosinophil peroxidase and major basic protein, inhibit mucin release from hamster tracheal surface epithelial cells in primary culture. Inflamm. Res. 48:314-317.
11. Wu, R., J. Yankaskas, E. Cheng, M. R. Knowles, and R. Boucher. 1985. Growth and differentiation of human nasal epithelial cells in culture: serum-free, hormone-supplemented medium and proteoglycan synthesis. Am. Rev. Respir. Dis. 132:311-320.
12. Wu, R., E. Nolan, and C. Turner. 1985. Expression of tracheal differentiated functions in serum-free hormone-supplemented medium. J. Cell. Physiol. 125:167-181.
13. Gray, T. E., K. Guzman, C. W. Davis, L. H. Abdullah, and P. Nettesheim. 1996. Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 14:104-112.
14. Kim, C. K., and B. C. Lee. 1991. P2 purinoceptor regulation of mucin release by airway goblet cells in primary culture. Br. J. Pharmacol. 103:1053-1056.
15. Jackson, A. D. 2001. Airway goblet-cell mucus secretion. Trends Pharmacol. Sci. 22:39-45.
16. 2 antagonists for the treatment of inflammatory diseases: abstract of papers, 224th ACS National Meeting, Boston, MA. MEDI-012.2. American Chemical Society, Washington, D.C. AR-CU8925XX (CA registry number [216657-60-2]).
17. Li, Y., L. D. Martin, G. Spizz, and K. B. Adler. 2001. MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro. J. Biol. Chem. 276:40982-40990.
18. Goswami, S., E. Gollub, D. J. Weiss, E. Gurpide, J. Roboz, and Z. Marom. 1994. Characterization of a unique mucin-like glycoprotein secreted by a human endometrial adenocarcinoma cell line (Ishikawa). Exp. Lung Res. 20:85-100.
19. Jackson, A. D., P. Kemp, J. Giddings, and R. Sugar 2002. Development and validation of a lectin-based assay for the quantitation of rat respiratory mucin. In Mucus Hypersecretion in Respiratory Disease. D. J. Chadwick and J. A. Goode, editors. Novartis Foundation, London.
20. Nollet, S., F. Escande, M. P. Buisine, M. E. Forgue-lafitte, P. Kirkham, Y. Okada, and J. Bara. 2004. Mapping of SOMU1 and M1 epitopes on the apomucin encoded by the 5′end of the MUC5AC gene. Hybrid. Hybridomics 23:93-99.
21. Ralevic, V., and G. Burnstock. 1998. Receptors for purines and pyrimidines. Pharmacol. Rev. 50:413-492.
22. Charlton, S. J., C. A. Brown, G. A. Weisman, J. T. Turner, L. Erb, and M. R. Boarder. 1996. Cloned and transfected P2Y4 receptors: characterization of a suramin and PPADS-insensitive response to UTP. Br. J. Pharmacol. 119:1301-1303.
23. Mukai, H., E. Munekata, and T. Higashijima. 1992. G protein antagonists: a novel hydrophobic peptide competes with receptor for G protein binding. J. Biol. Chem. 267:16237-16243.
24. Hunt, R. A., G. J. Bhat, and K. M. Baker. 1999. Angiotensin II-stimulated induction of sis-inducing factor is mediated by pertussis toxin-insensitive G(q) proteins in cardiac myocytes. Hypertension 34:603-608.
25. Wu, R., W. R. Martin, C. B. Robinson, J. A. St. George, C. G. Plopper, G. Kurland, J. A. Last, C. E. Cross, R. J. McDonald, and R. Boucher. 1990. Expression of mucin synthesis and secretion in human tracheobronchial epithelial cells grown in culture. Am. J. Respir. Cell Mol. Biol. 3:467-478.
26. Chen, Y., Y. H. Zhao, and R. Wu. 2001. Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates. Am. J. Respir. Cell Mol. Biol. 25:409-417.
27. Cui, Z. J., and T. Kanno. 1997. Photodynamic triggering of calcium oscillation in the isolated rat pancreatic acini. J. Physiol. 504:47-55.
28. Smith, R. J., L. M. Sam, J. M. Justen, G. L. Bundy, G. A. Bala, and J. E. Bleasdale. 1990. Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. J. Pharmacol. Exp. Ther. 253:688-697.
29. Homolya, L., T. H. Steinberg, and R. C. Boucher. 2000. Cell to cell communication in response to mechanical stress via bilateral release of ATP and UTP in polarized epithelia. J. Cell Biol. 150:1349-1360.
30. Rogers, D. F. 2001. Motor control of airway goblet cells and glands. Respir. Physiol. 125:129-144.
31. Liu, R., P. D. Bell, J. Peti-Peterdi, G. Kovacs, A. Johansson, and A. E. Persson. 2002. Purinergic receptor signaling at the basolateral membrane of macula densa cells. J. Am. Soc. Nephrol. 13:1145-1151.
32. Kim K. C., Q. X. Zheng, I. Van-Seuningen. 1993. Involvement of a signal transduction mechanism in ATP-induced mucin release from cultured airway goblet cells. Am. J. Respir. Cell Mol. Biol. 8:121-125.
33. Abdullah, L. H., J. D. Conway, J. A. Cohn, and C. W. Davis. 1997. Protein kinase C and Ca2+ activation of mucin secretion in airway goblet cells. Am. J. Physiol. 273:L201-L210.
34. Ko, K. H., M. Jo, K. McCracken, and K. C. Kim. 1997. ATP-induced mucin release from cultured airway goblet cells involves, in part, activation of protein kinase C. Am. J. Respir. Cell Mol. Biol. 16:194-198.
35. Abdullah, L. H., J. T. Bundy, C. Ehre, and C. W. Davis. 2003. Mucin secretion and PKC isoforms in the SPOC1 airway goblet cell line: differential effects of activation by purinergic agonist and PMA. Am. J. Physiol. Lung Cell. Mol. Physiol. 285:L149-L160.
36. Leipziger, J., D. Kerstan, R. Nitschke, and R. Greger. 1997. ATP increases [Ca2+]i and ion secretion via a basolateral P2Y-receptor in rat distal colonic mucosa. Pflugers Arch. 434:77-83.
37. Jumblatt, J. E., and M. M. Jumblatt. 1998. Regulation of ocular mucin secretion by P2Y2 nucleotide receptors in rabbit and human conjunctiva. Exp. Eye Res. 67:341-346.
38. Donaldson, S. H., E. R. Lazarowski, M. Picher, M. R. Knowles, M. J. Stutts, and R. C. Boucher. 2000. Basal nucleotide levels, release, and metabolism in normal and cystic flbrosis airways. Mol. Med. 6:969-982.
39. Wagner, J. A., S. S. Carlson, and R. B. Kelly. 1978. Chemical and physical characterization of cholinergic synaptic vesicles. Biochemistry 17:1199-1206.
40. Sauer, H., J. Hescheler, and M. Wartenberg. 2000. Mechanical strain-induced Ca(2+) waves are propagated via ATP release and purinergic receptor activation. Am. J. Physiol. 279:C295-C307.