Yohimbine Promotes Cardiac NE Release and Prevents LPS-Induced Cardiac Dysfunction via Blockade of Presynaptic α2A-Adrenergic Receptor

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Wang, Yiyang ^a   Yu, Xiaohui ^a   Wang, Faqiang ^a   Wang, Yuan ^a   Wang, Yanping ^a   Li, Hongmei ^a   Lv, Xiuxiu ^a   Lu, Daxiang ^a   Wang, Huadong ^a  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NORADRENALIN; RESERPINE; TUMOR NECROSIS FACTOR ALPHA; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOTOXEMIA; HEART DISEASE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE; HEART MUSCLE CELL; HEART PROTECTION; IMMUNOHISTOCHEMISTRY; KIDNEY INJURY; LIVER DYSFUNCTION; LUNG INJURY; MALE; MOUSE; NONHUMAN; NORADRENALIN BLOOD LEVEL; NORADRENALIN RELEASE; PHARMACOLOGICAL BLOCKING; PRESYNAPTIC MEMBRANE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SYMPATHETIC NERVE; TISSUE LEVEL;

ADRENERGIC ALPHA-2 RECEPTOR ANTAGONISTS; ANIMALS; APOPTOSIS; HEART; LIPOPOLYSACCHARIDES; LIVER; MALE; MICE; MICE, INBRED BALB C; MYOCYTES, CARDIAC; NITRIC OXIDE; NOREPINEPHRINE; ORGAN SPECIFICITY; PRESYNAPTIC TERMINALS; PROTEIN TRANSPORT; RECEPTORS, ADRENERGIC, ALPHA-2; RESERPINE; SYNAPSES; TUMOR NECROSIS FACTOR-ALPHA; YOHIMBINE;

EID: 84877784571     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063622     Document Type: Article

References (31)

1. Wiersinga WJ, van der Poll T, (2010) Sepsis: new insights into its pathogenesis and treatment. Ned Tijdschr Geneeskd 154: A1130.
2. Merx MW, Weber C, (2007) Sepsis and the heart. Circulation 116: 793-802.
3. McDonald TE, Grinman MN, Carthy CM, Walley KR, (2000) Endotoxin infusion in rats induces apoptotic and survival pathways in hearts. Am J Physiol Heart Circ Physiol 279: H2053-H2061.
4. Lancel S, Joulin O, Favory R, Goossens JF, Kluza J, et al. (2005) Ventricular myocyte caspases are directly responsible for endotoxin-induced cardiac dysfunction. Circulation 111: 2596-2604.
5. Zhang T, Feng Q, (2010) Nitric oxide and calcium signaling regulate myocardial tumor necrosis factor-α expression and cardiac function in sepsis. Can J Physiol Pharmacol 88: 92-104.
6. Carlson DL, Willis MS, White DJ, Horton JW, Giroir BP, (2005) Tumor necrosis factor-alpha-induced caspase activation mediates endotoxin-related cardiac dysfunction. Crit Care Med 33: 1021-1028.
7. Fernandes CJ Jr, de Assuncao MS, (2012) Myocardial dysfunction in sepsis: a large, unsolved puzzle. Crit Care Res Pract 2012: 896430.
8. Wang YY, Li HM, Wang HD, Peng XM, Wang YP, et al. (2011) Pretreatment with berberine and yohimbine protects against LPS-induced myocardial dysfunction via inhibition of cardiac I-κBα phosphorylation and apoptosis in mice. Shock 35: 322-328.
9. Gyires K, Zádori ZS, Török T, Mátyus P, (2009) alpha (2)-Adrenoceptor subtypes- mediated physiological, pharmacological actions. Neurochem Int 55: 447-453.
10. Miksa M, Das P, Zhou M, Wu R, Dong W, et al. (2009) Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis. PLoS One 4: e5504.
11. Zhang F, Wu R, Qiang X, Zhou M, Wang P, (2010) Antagonism of alpha2A-adrenoceptor: a novel approach to inhibit inflammatory responses in sepsis. J Mol Med (Berl) 88: 289-296.
12. Kang BY, Lee SW, Kim TS, (2003) Stimulation of interleukin-12 production in mouse macrophages via activation of p38 mitogen-activated protein kinase by alpha2-adrenoceptor agonists. Eur J Pharmacol 467: 223-231.
13. Simms MG, Walley KR, (1999) Activated macrophages decrease rat cardiac myocyte contractility: importance of ICAM-1-dependent adhesion. Am J Physiol 277: H253-H260.
14. Zhang HQ, Wang HD, Lu DX, Qi RB, Wang YP, et al. (2008) Berberine inhibits cytosolic phospholipase A2 and protects against LPS-induced lung injury and lethality independent of the alpha2-adrenergic receptor in mice. Shock 29: 617-622.
15. Cheng ZQ, Bose D, Jacobs H, Light RB, Mink SN, (2002) Sepsis causes presynaptic histamine H3 and alpha2-adrenergic dysfunction in canine myocardium. Cardiovasc Res 56: 225-234.
16. Smart KR Jr, Warejcka DJ, Castresana MR, Dalton ML, Webb JG, et al. (2000) Isoproterenol inhibits bacterial lipopolysaccharide-stimulated release of tumor necrosis factor-alpha from human heart tissue. Am Surg 66: 947-951.
17. Martínez-Olivares R, Villanueva I, Racotta R, Piñón M, (2006) Depletion and recovery of catecholamines in several organs of rats treated with reserpine. Auton Neurosci 128: 64-69.
18. Baumgarten G, Knuefermann P, Nozaki N, Sivasubramanian N, Mann DL, et al. (2001) In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4. J Infect Dis 183: 1617-1624.
19. Peng T, Lu X, Lei M, Moe GW, Feng Q, (2003) Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia. Cardiovasc Res 59: 893-900.
20. Tatsumi T, Akashi K, Keira N, Matoba S, Mano A, et al. (2004) Cytokine-induced nitric oxide inhibits mitochondrial energy production and induces myocardial dysfunction in endotoxin-treated rat hearts. J Mol Cell Cardiol 37: 775-784.
21. Schlag G, Redl H, Hallström S, (1991) The cell in shock: the origin of multiple organ failure. Resuscitation 21: 137-180.
22. Grigoleit JS, Kullmann JS, Wolf OT, Hammes F, Wegner A, et al. (2011) Dose-dependent effects of endotoxin on neurobehavioral functions in humans. PLoS One 6: e28330.
23. Spengler RN, Allen RM, Remick DG, Strieter RM, Kunkel SL, (1990) Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor. J Immunol 145: 1430-1434.
24. Yang J, Wang HD, Lu DX, Wang YP, Qi RB, et al. (2006) Effects of neutral sulfate berberine on LPS-induced cardiomyocyte TNF-alpha secretion, abnormal calcium cycling, and cardiac dysfunction in rats. Acta Pharmacol Sin 27: 173-178.
25. Seitelberger R, Guth BD, Heusch G, Lee JD, Katayama K, et al. (1988) Intracoronary alpha 2- adrenergic receptor blockade attenuates ischemia in conscious dogs during exercise. Circ Res 62: 436-342.
26. Heusch G, (2011) The paradox of α-adrenergic coronary vasoconstriction revisited. J Mol Cell Cardiol 51: 16-23.
27. Yang S, Koo DJ, Zhou M, Chaudry IH, Wang P, (2000) Gut-derived norepinephrine plays a critical role in producing hepatocellular dysfunction during early sepsis. Am J Physiol Gastrointest Liver Physiol 279: G1274-G1281.
28. Flierl MA, Rittirsch D, Nadeau BA, Chen AJ, Sarma JV, et al. (2007) Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature 449: 721-725.
29. Koganei H, Takeuchi A, Kimura T, Satoh S, (1995) Effects of yohimbine and desipramine on adrenal catecholamine release in response to splanchnic nerve stimulation in anesthetized dogs. Pharm Bull 18: 1207-1210.
30. Chopra M, Sharma AC, (2009) Contractile response of norepinephrine is modulated by caspase-3 in adult rat ventricular myocytes isolated from septic rat heart. Pharmacol Res 60: 303-313.
31. Iwai-Kanai E, Hasegawa K, Araki M, Kakita T, Morimoto T, et al. (1999) Alpha- and beta-adrenergic pathways differentially regulate cell type-specific apoptosis in rat cardiac myocytes. Circulation 100: 305-311.