Stimulation of interleukin-12 production in mouse macrophages via activation of p38 mitogen-activated protein kinase by α2-adrenoceptor agonists

European Journal of Pharmacology

Volumn 467, Issue 1-3, 2003, Pages 223-231

  Kang, Bok Yun ^a   Lee, Seung Won ^b   Kim, Tae Sung ^a  

^a Chonnam National University   (South Korea)

^b Chonnam National University Medical School   (South Korea)

Author keywords

Interleukin 12; Macrophage; P38 Mitogen activated protein kinase; 2 Adrenoceptor agonist

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 ETHYL 2 (4 ACETYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 ETHYL 2 (4 METHOXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ACTIN; CHELERYTHRINE; CLONIDINE; FORSKOLIN; GUANFACINE; IMIDAZOLE DERIVATIVE; INTERLEUKIN 12; INTERLEUKIN 18; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OXYMETAZOLINE; PROTEIN KINASE C INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WORTMANNIN; YOHIMBINE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; FEMALE; IMMUNE RESPONSE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0037466475     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(03)01628-5     Document Type: Article

References (43)

1. Aicher A., Shu G.L., Mageletti D., Mulvania T., Pezzutto A., Craxton A., Clark E.A. Differential role for p38 mitogen-activated protein kinase in regulating CD40-induced gene expression in dendritic cells and B cells. J. Immunol. 163:1999;5786-5795.
2. Amrani Y., Ammit A.J., Panettieri R.A. Jr. Tumor necrosis factor receptor (TNFR) 1, but not TNFR2, mediates tumor necrosis factor-α-induced interleukin-6 and RANTES in human airway smooth muscle cells: role of p38 and p42/44 mitogen-activated protein kinases. Mol. Pharmacol. 60:2001;646-655.
3. Benschop R.J., Jacobs R., Sommer B., Schurmeyer T.H., Raab J.R., Schmidt R.E., Schedlowski M. Modulation of the immunologic response to acute stress in humans by β-blockage or benzodiazepines. FASEB J. 10:1996;517-524.
4. 2-adrenoceptor subtype. Am. J. Respir. Cell Mol. Biol. 19:1998;400-407.
5. Bryan S.A., O'Connor B.J., Matti S., Leckie M.J., Kanabar V., Khan J., Warrington S.J., Renzetti L., Rames A., Bock J.A., Boyce M.J., Hansel T.T., Holgate S.T., Barnes P.J. Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet. 356:2000;2149-2153.
6. + channel currents. J. Biol. Chem. 276:2001;47512-47517.
7. Chambers D.A., Cohen R.L., Perlman R.L. Neuroimmune modulation: signal transduction and catecholamines. Neurochem. Int. 22:1993;95-110.
8. Chou R.C., Stinson M.W., Noble B.K., Spengler R.N. β-adrenergic receptor regulation of macrophage-derived tumor necrosis factor-α production from rats with experimental arthritis. J. Neuroimmunol. 67:1996;7-16.
9. Chung S.W., Kang B.Y., Kim S.H., Pak Y.K., Cho D., Trinchieri G., Kim T.S. Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated macrophages via direct interactions between peroxisome proliferator-activated receptor-γ and nuclear factor-κB. J. Biol. Chem. 275:2000;32681-32687.
10. Elenkov I.J., Papanicolaou D.A., Wilder R.L., Chrousos G.P. Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications. Proc. Assoc. Am. Physicians. 108:1996;374-381.
11. Feng G.J., Goodridge H.S., Harnett M.M., Wei X.Q., Nikolaev A.V., Higson A.P., Liew F.Y. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. J. Immunol. 163:1999;6403-6412.
12. + melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12. Clin. Cancer Res. 7:2001;895-901.
13. Gately M.K., Renzetti L.M., Magram J., Stern A.S., Adorini L., Gubler U., Presky D.H. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16:1998;495-521.
14. Gollob J.A., Mier J.W., Atkins M.B. Clinical use of systemic IL-12 therapy. Cancer Chemother. Biol. Response Modif. 19:2001;353-369.
15. Gri G., Savio D., Trinchieri G., Ma X. Synergistic regulation of the human interleukin-12 p40 promoter by NF-κB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages. J. Biol. Chem. 273:1998;6431-6438.
16. Han Z.S., Enslen H., Hu X., Meng X., Wu I.H., Barrett T., Davis R.J., Ip Y.T. A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Mol. Cell. Biol. 18:1998;3527-3539.
17. Hasko G., Szabo C., Nemeth Z.H., Salzman A.L., Vizi E.S. Stimulation of β-adrenoceptors inhibits endotoxin-induced IL-12 production in normal and IL-10 deficient mice. J. Neuroimmunol. 88:1998;57-61.
18. Hodge-Dufour J., Noble P.W., Horton M.R., Bao C., Wysoka M., Burdick M.D., Strieter R.M., Trinchieri G., Pure E. Induction of IL-12 and chemokines by hyaluronan require adhesion-dependent priming of resident but not elicited macrophages. J. Immunol. 159:1997;2492-2500.
19. Holland S.M. Immunotherapy of mycobacterial infections. Semin. Respir. Infect. 16:2001;47-59.
20. Kang B.Y., Chung S.W., Chung W.-J., Im S.-Y., Hwang S.Y., Kim T.S. Inhibition of interleukin-12 production in lipopolysaccharide-activated macrophages by curcumin. Eur. J. Pharmacol. 384:1999;191-195.
21. 2A-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels. J. Biol. Chem. 275:2000;1763-1772.
22. Kincy-Cain T., Bost K.L. Substance P-induced IL-12 production by murine macrophages. J. Immunol. 158:1997;2334-2339.
23. Lahti A., Kankaanranta H., Moilanen E. P38 mitogen-activated protein kinase inhibitor SB203580 has a bi-directional effect on iNOS expression and NO production. Eur. J. Pharmacol. 454:2002;115-123.
24. Le Tulzo Y., Shenkar R., Kaneko D., Moine P., Fantuzzi G., Dinarello C.A., Abraham E. Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of catecholamines in nuclear factor-κB regulation and cytokine expression. J. Clin. Invest. 99:1997;1516-1524.
25. Liggett S.B. β-adrenoceptor-effector system of the human macrophage U937 cell line. Eur. J. Pharmacol. 163:1989;171-174.
26. 2+ during endotoxic shock. Circ. Shock. 37:1992;317-322.
27. Mason N., Aliberti J., Caamano J.C., Liou H.C., Hunter C.A. Identification of c-Rel-dependent and -independent pathways of IL-12 production during infectious and inflammatory stimuli. J. Immunol. 168:2002;2590-2594.
28. Miles B.A., Lafuse W.P., Zwilling B.S. Binding of α-adrenergic receptors stimulates the anti-mycobacterial activity of murine peritoneal macrophages. J. Neuroimmunol. 71:1996;19-24.
29. Mullins D.W., Burger C.J., Elgert K.D. Paclitaxel enhances macrophage IL-12 production in tumor-bearing hosts through nitric oxide. J. Immunol. 162:1999;6811-6818.
30. 2-agonists prevent Th1 development by selective inhibition of interleukin 12. J. Clin. Invest. 100:1997;1513-1519.
31. Pastores S.M., Hasko G., Vizi E.S., Kvetan V. Cytokine production and its manipulation by vasoactive drugs. New Horiz. 4:1996;252-264.
32. Rieckmann P., Weber F., Gunther A., Martin S., Bitsch A., Broocks A., Kitze B., Weber T., Borner T., Poser S. Pentoxifylline, a phosphodiesterase inhibitor, induces immune deviation in patients with multiple sclerosis. J. Neuroimmunol. 64:1996;193-200.
33. Rincon M., Enslen H., Raingeaud J., Recht M., Zapton T., Su M.S., Penix L.A., Davis R.J., Flavell R.A. Interferon-γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J. 17:1998;2817-2829.
34. 2-adrenergic mechanisms. J. Immunol. 156:1996;93-99.
35. Severn A., Rapson N.T., Hunter C.A., Liew F.Y. Regulation of tumor necrosis factor production by adrenaline and β-adrenergic agonists. J. Immunol. 148:1992;3441-3445.
36. Shibata Y., Metzger W.J., Myrvik Q.N. Chitin particle-induced cell-mediated immunity is inhibited by soluble mannan: mannose receptor-mediated phagocytosis initiates IL-12 production. J. Immunol. 159:1997;2462-2467.
37. 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with GαC-terminal antibodies. Proc. Natl. Acad. Sci. U. S. A. 86:1989;7809-7813.
38. d molecules at the cell surface. J. Exp. Med. 178:1993;2035-2046.
39. Spengler R.N., Allen R.M., Remick D.G., Strieter R.M., Kunkel S.L. Stimulation of α-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor. J. Immunol. 145:1990;1430-1434.
40. 1E cDNA. Am. J. Physiol., Cell Physiol. 280:2001;175-182.
41. Trinchieri G. Proinflammatory and immunoregulatory functions of interleukin-12. Int. Rev. Immunol. 16:1998;365-396.
42. 2 is a potent inhibitor of human inteleukin 12 production. J. Exp. Med. 181:1995;775-779.
43. Zhang S., Kaplan M.H. The p38 mitogen-activated protein kinase is required for IL-12 induced IFN-γ expression. J. Immunol. 165:2000;1374-1380.