Pivotal role of the α2A-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis

PLoS ONE

Volumn 4, Issue 5, 2009, Pages

  Miksa, Michael ^a   Das, Padmalaya ^a   Zhou, Mian ^a   Wu, Rongqian ^a   Dong, Weifeng ^a   Ji, Youxin ^a   Goyert, Sanna M ^a,b   Ravikumar, Thanjavur S ^a   Wang, Ping ^a  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b CITY COLLEGE OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; ALPHA 2A ADRENERGIC RECEPTOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; NORADRENALIN; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; IMIDAZOLE DERIVATIVE; ISOINDOLE DERIVATIVE; RECEPTOR, ADRENERGIC, ALPHA 2A; RECEPTOR, ADRENERGIC, ALPHA-2A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; DISEASE MODEL; ENDOTOXEMIA; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; INFLAMMATION; INTESTINE SURGERY; KUPFFER CELL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGAN INJURY; PROTEIN SECRETION; RAT; RECEPTOR BINDING; RECEPTOR UPREGULATION; SEPSIS; SURVIVAL RATE; ANIMAL; BINDING COMPETITION; BLOOD; CECUM; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; HEART RATE; INJURY; LIGATION; LIVER; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PUNCTURE; RADIOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL;

ANIMALIA; RATTUS;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BINDING, COMPETITIVE; CECUM; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; GENE EXPRESSION; HEART RATE; IMIDAZOLES; INFLAMMATION; ISOINDOLES; KUPFFER CELLS; LIGATION; LIVER; MALE; NOREPINEPHRINE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PUNCTURES; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEPSIS; SURVIVAL ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 65549157193     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005504     Document Type: Article

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