Contractile response of norepinephrine is modulated by caspase-3 in adult rat ventricular myocytes isolated from septic rat heart

Pharmacological Research

Volumn 60, Issue 4, 2009, Pages 303-313

  Chopra, Mani ^a   Sharma, Avadhesh C ^a  

^a BAYLOR COLLEGE OF DENTISTRY   (United States)

Author keywords

Cardiomyocyte; Caspase 3 siRNA; Confocal microscopy; Contractility; Polymicrobial sepsis; Shock; TUNEL

Indexed keywords

ATENOLOL; CASPASE 3; NORADRENALIN; PRAZOSIN; SMALL INTERFERING RNA;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; GENETIC TRANSFECTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE CONTRACTION; HEART VENTRICLE FAILURE; HEART VENTRICLE WALL; MALE; MOLECULAR MECHANICS; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE; SEPSIS; UPREGULATION;

ADRENERGIC ALPHA-AGONISTS; AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; ATENOLOL; CASPASE 3; CELLS, CULTURED; GENE EXPRESSION; MALE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NOREPINEPHRINE; PRAZOSIN; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS;

EID: 69249218006     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2009.04.009     Document Type: Article

References (40)

1. Kochanek K.D., and Smith B.L. Deaths: Preliminary data for 2002. Natl Vital Stat Rep 52 (2004) 1-48
2. Maeder M., Fehr T., Rickli H., and Ammann P. Sepsis-associated myocardial dysfunction, diagnostic and prognostic impact of cardiac troponins and natriuretic peptides. Chest 129 (2006) 1349-1366
3. Parrillo J.E., Parker M.M., Natanson C., Suffredini A.F., Danner R.L., Cunnion R.E., et al. Septic shock in humans: advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann Intern Med 113 (1990) 227-242
4. Levy R.J., and Deutschman C.S. Evaluating myocardial depression in sepsis. Shock 22 (2004) 1-10
5. Rabuel C., and Mebazaa A. Septic shock: A heart story since the 1960s. Intensive Care Med 32 (2006) 799-807
6. Sharma A.C. Sepsis-induced myocardial dysfunction. Shock 28 (2007) 265-269
7. Chopra M., and Sharma A.C. Distinct cardiodynamic and molecular characteristics during early and late stages of sepsis-induced myocardial dysfunction. Life Sci 81 (2007) 306-316
8. Gupta A., Aberle II N.S., Ren J., and Sharma A.C. Endothelin-converting enzyme-1-mediated signaling in adult rat ventricular myocyte contractility and apoptosis during sepsis. J Mol Cell Cardiol 38 (2005) 527-537
9. Merx M.W., and Weber C. Sepsis and the heart. Circulation 116 (2007) 793-802
10. Sharma A.C., Motew S.J., Farias S., Alden K.J., Bosmann H.B., Law W.R., et al. Sepsis alters myocardial and plasma concentrations of endothelin and nitric oxide in rats. J Mol Cell Cardiol 29 (1997) 1469-1477
11. Tung R.H., Garcia C., Morss A.M., Pino R.M., Fifer M.A., Thompson B.T., et al. Utility of B-type natriuretic peptide for the evaluation of intensive care unit shock. Crit Care Med 32 (2004) 1643-1647
12. Di Giantomasso D., Bellomo R., and May C.N. The haemodynamic and metabolic effects of epinephrine in experimental hyperdynamic septic shock. Intensive Care Med 31 (2005) 454-462
13. Rona G. Catecholamine cardiotoxicity. J Mol Cell Cardiol 17 (1985) 291-306
14. Mann D.L., Kent R.L., Parsons B., and Cooper G. Adrenergic effects on the biology of the adult mammalian cardiomyocyte. Circulation 85 (1992) 790-804
15. Opie L.H., Walpoth B., and Barsacchi R. Calcium and catecholamines: relevance to cardiomyopathies and significance in therapeutic strategies. J Mol Cell Cardiol 17 (1985) 21-34
16. Hotchkiss R.S., Swanson P.E., Freeman B.D., Tinsley K.W., Cobb J.P., Matuschak G.M., et al. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27 (1999) 1230-1251
17. Wesche-Soldato D.E., Swan R.Z., Chung C.S., and Ayala A. The apoptotic pathway as a therapeutic target in sepsis. Curr Drug Targets 8 (2007) 493-500
18. Beranek J.T. Cardiomyocyte apoptosis contributes to the pathology of the septic shock heart. Intensive Care Med 28 (2002) 218-219
19. Porter A.G., and Janicke R.U. Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6 (1999) 99-104
20. Nevière R., Fauvel H., Chopin C., Formstecher P., and Marchetti P. Caspase inhibition prevents cardiac dysfunction and heart apoptosis in a rat model of sepsis. Am J Respir Crit Care Med 163 (2001) 218-225
21. Laugwitz K.L., Moretti A., Weig H.J., Gillitzer A., Pinkernell K., Ott T., et al. Blocking caspase-activated apoptosis improves contractility in failing myocardium. Hum Gene Ther 12 (2001) 2051-2063
22. Communal C., Sumandea M., de Tombe P., Narula J., Solaro R.J., and Hajjar R.J. Functional consequences of caspase activation in cardiac myocytes. Proc Natl Acad Sci USA 99 (2002) 6252-6256
23. Moretti A., Weig H.J., Ott T., Seyfarth M., Holthoff H.P., Grewe D., et al. Essential myosin light chain as a target for caspase-3 in failing myocardium. Proc Natl Acad Sci USA 99 (2002) 11860-11865
24. Ren J., Ren B.H., and Sharma A.C. Sepsis-induced depressed contractile function of isolated ventricular myocytes is due to altered calcium transient properties. Shock 18 (2002) 285-288
25. Sam II A.D., Sharma A.C., Law W.R., and Ferguson J.L. Splanchnic vascular control during sepsis and endotoxemia. Front Biosci 2 (1997) e72-e92
26. Gupta A., Brahmbhatt S., Kapoor R., Loken L., and Sharma A.C. Chronic peritoneal sepsis: myocardial dysfunction, endothelin and signaling mechanisms. Front Biosci 10 (2005) 3183-3205
27. Carlson D.L., Maass D.L., White J., Sikes P., and Horton J.W. Caspase inhibition reduces cardiac myocyte dyshomeostasis and improves cardiac contractile function after major burn injury. J Appl Physiol 103 (2007) 323-330
28. Colucci W.S., Sawyer D.B., Singh K., and Communal C. Adrenergic overload and apoptosis in heart failure: implications for therapy. J Card Fail 6 (2000) 1-7
29. Zhou M., Yang S., Koo D.J., Ornan D.A., Chaudry I.H., and Wang P. The role of Kupffer cell alpha (2) adrenoceptors in norepinephrine-induced TNF-alpha production. Biochim Biophys Acta 1537 (2001) 49-57
30. Srinivasula S.M., Ahmad M., Fernandes-Alnemri T., Litwack G., and Alnemri E.S. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc Natl Acad Sci USA 93 (1996) 14486-14491
31. Muzio M., Salvesen G.S., and Dixit V.M. FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J Biol Chem 272 (1997) 2952-2956
32. Takahashi A., Hirata H., Yonehara S., Imai Y., Lee K.K., Moyer R.W., et al. Affinity labeling displays the stepwise activation of ICE-related proteases by Fas, staurosporine, and CrmA-sensitive caspase-8. Oncogene 14 (1997) 2741-2752
33. Stennicke H.R., Jürgensmeier J.M., Shin H., Deveraux Q., Wolf B.B., Yang X., et al. Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem 273 (1998) 27084-27090
34. Earnshaw W.C., Martins L.M., and Kaufmann S.H. Mammalian Caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68 (1999) 383-424
35. Remondino A., Kwon S.H., Communal C., Pimentel D.R., Sawyer D.B., Singh K., et al. Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway. Circ Res 92 (2003) 136-138
36. Shyu K.G., Kuan P., Chang M.L., Wang B.W., and Huang F.Y. Effects of norepinephrine on apoptosis in rat neonatal cardiomyocytes. J Formos Med Assoc 99 (2000) 412-418
37. Charpentier J., Luyt C.E., Fulla Y., Vinsonneau C., Cariou A., Grabar S., et al. Brain natriuretic peptide: A marker of myocardial dysfunction and prognosis during severe sepsis. Crit Care Med 32 (2004) 660-665
38. Zaugg M., Jamali N.Z., Lucchinetti E., Shafiq S.A., and Siddiqui M.A. Norepinephrine-induced apoptosis is inhibited in adult rat ventricular myocytes exposed to volatile anesthetics. Anesthesiology 93 (2000) 209-218
39. Chang J., Wei L., Otani T., Youker K.A., Entman M.L., and Schwartz R.J. Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading. Circulation 108 (2003) 407-413
40. Wu L.L., Tang C., and Liu M.S. Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis. Am J Physiol Regul Integr Comp Physiol 281 (2001) R408-R416