Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia

Leukemia and Lymphoma

Volumn 54, Issue 6, 2013, Pages 1159-1164

  Zou, Zhi Jian ^a   Zhang, Run ^a   Fan, Lei ^a   Wang, Li ^a   Fang, Cheng ^a   Zhang, Li Na ^a   Yang, Shu ^a   Li, Yuan Yuan ^a   Li, Jian Yong ^a   Xu, Wei ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Chronic lymphocytic leukemia; Prognosis; PTEN

Indexed keywords

BETA 2 MICROGLOBULIN; LACTATE DEHYDROGENASE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; CYTOGENETICS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MUTATION; PROGNOSIS; PTEN PHOSPHOHYDROLASE; ROC CURVE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84877761870     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2012.733880     Document Type: Article

References (33)

1. Chiorazzi N, Rai KR, Ferrarini M . Chronic lymphocytic leukemia. N Engl J Med 2005; 352: 804- 815.
2. Rai KR . Pathophysiologic mechanisms of chronic lymphocytic leukemia and their application to therapy. Exp Hematol 2007; 35: 134- 136.
3. Dighiero G, Hamblin TJ . Chronic lymphocytic leukaemia . Lancet 2008; 371 : 1017 - 1029.
4. Di Cristofano A, Pandolfi PP . The multiple roles of PTEN in tumor suppression . Cell 2000; 100 : 387 - 390.
5. M izoguchi M, N utt C L, M ohapatra G, et a l. G enetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas. Brain Pathol 2004; 14 : 372 - 377.
6. Oda K, Stokoe D, Taketani Y, et al . High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma Cancer Res 2005; 65: 10669- 10673.
7. Ollikainen M, Gylling A, Puputti M, et al . Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma . Int J Cancer 2007; 121 : 915 - 920.
8. Nakatani K, Th ompson DA, Barthel A, et al . Up-regulation of Akt3 in estrogen receptor-defi cient breast cancers and androgen-independent prostate cancer lines . J Biol Chem 1999; 274 : 21528 - 21532.
9. G allia G L.R and V, S iu I M, et a l. P IK3CA gene mutations in pediatric and adult glioblastoma multiforme . Mol Cancer Res 2006; 4 : 709 - 714.
10. Bellacosa A, de Feo D, Godwin AK, et al . Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas . Int J Cancer 1995; 64 : 280 - 285.
11. Zhuang J, Hawkins SF, Glenn MA, et al . Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: The therapeutic potential of Akt inhibition. Haematologica 2010; 95: 110- 118.
12. Shehata M, Schnabl S, Demirtas D, et al . Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia . Blood 2010; 116: 2513- 2521.
13. H allek M, C heson B D, C atovsky D, et a l. G uidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 2008 ; 111 : 5446 - 5456.
14. B inet J L, A uquier A, D ighiero G, et a l. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis . Cancer 1981; 48: 198- 206.
15. Xu W, Li JY, Shen QD, et al . Expression level of lipoprotein lipase in Chinese patients with chronic lymphocytic leukemia and its correlation with other prognostic factors . Int J Lab Hematol 2009; 31 : 552 - 559.
16. D urig J, N uckel H, C remer M, et a l. Z AP-70 expression is a prognostic factor in chronic lymphocytic leukemia . Leukemia 2003; 17 : 2426 - 2434.
17. Takashima T, Itoh M, Ueda Y, et al . Detection of 14q32.33 translocation and t(11;14) in interphase nuclei of chronic B-cell leukemia/lymphomas by in situ hybridization. Int J Cancer 1997; 72: 31- 38.
18. Dong HJ, Zhou LT, Zhu DX, et al . The prognostic signifi cance of TP53 mutations in Chinese patients with chronic lymphocytic leukemia is independent of del(17p13) . Ann Hematol 2011; 90 : 709 - 717.
19. D ohner H, S tilgenbauer S, B enner A, et a l. G enomic aberrations and survival in chronic lymphocytic leukemia . N Engl J Med 2000; 343 : 1910 - 1916.
20. Krober A, Seiler T, Benner A, et al . V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia . Blood 2002; 100: 1410- 1416.
21. B arragan M, C ampas C, B ellosillo B, et a l. P rotein kinases in the regulation of apoptosis in B-cell chronic lymphocytic leukemia . Leuk Lymphoma 2003; 44: 1865- 1870.
22. Escobar-Diaz E, Lopez-Martin EM, Hernandez del Cerro M, et al . AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: Interference with the Akt/NF-kappaB survival pathway. Leukemia 2005; 19: 572- 579.
23. Wu X, Senechal K, Neshat MS, et al . The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway . Proc Natl Acad Sci USA 1998; 95 : 15587 - 15591.
24. Maddocks KJ, Lin TS . Update in the management of chronic lymphocytic leukemia . J Hematol Oncol 2009; 2: 29.
25. C han C H, G ao Y, M oten A, et a l. N ovel ARF/p53-independent senescence pathways in cancer repression . J Mol Med (Berl) 2011; 89 : 857 - 867.
26. Leupin N, Cenni B, Novak U, et al . Disparate expression of the PTEN gene: A novel fi nding in B-cell chronic lymphocytic leukaemia (B-CLL) . Br J Haematol 2003; 121 : 97 - 100.
27. Khwaja A . PI3K as a target for therapy in haematological malignancies . Curr Top Microbiol Immunol 2010; 347: 169- 188.
28. Montiel-Duarte C, C ordeu L, A girre X, et a l. R esistance to imatinib mesylate-induced apoptosis in acute lymphoblastic leukemia is associated with PTEN down-regulation due to promoter hypermethylation. Leuk Res 2008; 32: 709- 716.
29. Calin GA, Dumitru CD, Shimizu M, et al . Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia . Proc Natl Acad Sci USA 2002; 99 : 15524 - 15529.
30. D ong C, J i M, J i C . m icroRNAs and their potential target genes in leukemia pathogenesis . Cancer Biol Ther 2009; 8 : 200 - 205.
31. Vogelstein B, Lane D, Levine AJ . Surfi ng the p53 network. N ature 2000; 408 : 307 - 310.
32. Stambolic V, MacPherson D, Sas D, et al . Regulation of PTEN transcription by p53 . Mol Cell 2001; 8 : 317 - 325.
33. Freeman DJ, Li AG, Wei G, et al . PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms . Cancer Cell 2003; 3 : 117 - 130.