Optimization of stress response through the nuclear receptor-mediated cortisol signalling network

Nature Communications

Volumn 4, Issue , 2013, Pages

  Kolodkin, Alexey ^a   Sahin, Nilgun ^b   Phillips, Anna ^c   Hood, Steve R ^d   Bruggeman, Frank J ^b,e   Westerhoff, Hans V ^b,f,g   Plant, Nick ^c  

^a UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c UNIVERSITY OF SURREY   (United Kingdom)

^d GLAXOSMITHKLINE   (United Kingdom)

^e CWI   (Netherlands)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

^g UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; LIGAND; PREGNANE X RECEPTOR; CELL RECEPTOR; STEROID RECEPTOR;

ADAPTATION; ALCOHOL; DEVELOPMENTAL BIOLOGY; DISEASE PREVALENCE; HORMONE; LIGAND; OPTIMIZATION; PARADIGM SHIFT; PHYSIOLOGICAL RESPONSE; PHYSIOLOGY; RISK FACTOR; SIGNALING;

ARTICLE; CHRONIC STRESS; HUMAN; HUMAN CELL; KINETICS; RECEPTOR AFFINITY; RISK; ADAPTATION; BIOLOGICAL MODEL; FEEDBACK SYSTEM; GENE REGULATORY NETWORK; GENETICS; METABOLISM; PHYSIOLOGICAL STRESS; REPRODUCIBILITY; SIGNAL TRANSDUCTION;

ADAPTATION, PHYSIOLOGICAL; FEEDBACK, PHYSIOLOGICAL; GENE REGULATORY NETWORKS; HUMANS; HYDROCORTISONE; LIGANDS; MODELS, BIOLOGICAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, GLUCOCORTICOID; RECEPTORS, STEROID; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL;

EID: 84877760760     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms2799     Document Type: Article

References (40)

1. Kitano, H. Biological robustness. Nat. Rev. Genet. 5, 826-837 (2004). (Pubitemid 39457498)
2. Koefoed, S. et al. A turbo engine with automatic transmission? How to many chemicomotion to the subtleties and robustness of life. Biochim. Biophys. Acta-Bioenergetics 1555, 75-82 (2002). (Pubitemid 35246009)
3. Goligorsky, M. S. The concept of cellular 'fight-or-flight' reaction to stress. Am. J. Physiol.-Renal Physiol. 280, F551-F561 (2001).
4. Shively, C. A., Register, T. C. & Clarkson, T. B. Social stress, visceral obesity, and coronary artery atherosclerosis: product of a primate adaptation. Am. J. Primatol. 71, 742-751 (2009).
5. Conrad, C. D. A critical review of chronic stress effects on spatial learning and memory. Prog. Neuropsychopharmacol. Biol. Psychiatry 34, 742-755 (2010).
6. Conrad, C. D. Chronic stress-induced hippocampal vulnerability: the glucocorticoid vulnerability hypothesis. Rev. Neurosci. 19, 395-411 (2008).
7. Fabre, B. et al. Relationship between cortisol, life events and metabolic syndrome in men. Stress 16, 16-23 (2013).
8. Hartley, T. A. et al. Association between depressive symptoms and metabolic syndrome in police officers: results from two cross-sectional studies. J. Environ. Health 2012, 861219 (2012).
9. Plant, N. & Aouabdi, S. Nuclear receptors: the controlling force in drug metabolism of the liver? Xenobiotica 39, 597-605 (2009).
10. Francis, G. A., Fayard, E., Picard, F. & Auwerx, J. Nuclear receptors and the control of metabolism. Ann. Rev. Physiol. 65, 261-311 (2003). (Pubitemid 38249155)
11. Pascussi, J.-M., Drocourt, L., Fabre, J.-M., Maurel, P. & Vilarem, M.-J. Dexamethasone induces pregnane X receptor and retinoid X receptor-a expression in human hepatocytes: Synergistic increase of CYP3A4 induction by pregnane X receptor. Mol. Pharmacol. 58, 361-372 (2000). (Pubitemid 30497480)
12. Aouabdi, S., Gibson, G. G. & Plant, N. Transcriptional regulation of PXR: Identification of a PPRE within the proximal promoter responsible for fibrate-mediated transcriptional activation of PXR. Drug Metab. Dispos. 34, 138-144 (2006). (Pubitemid 43042655)
13. Oakley, R. H. & Cidlowski, J. A. Homologous down regulation of the glucocorticoid receptor: the molecular machinery. Crit. Rev. Eukaryot. Gene Expr. 3, 63-88 (1993). (Pubitemid 23163668)
14. Gibson, G. G., Phillips, A., Aouabdi, S., Plant, K. & Plant, N. Transcriptional regulation of the human pregnane-X receptor. Drug Metab. Rev. 38, 31-49 (2006). (Pubitemid 43738998)
15. Bailey, I., Gibson, G. G., Plant, K., Graham, M. & Plant, N. A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16a-carbonitrile. PLoS ONE 6, e16703 (2011).
16. Arda, H. E. et al. Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans gene regulatory network. Mol. Sys. Biol. 6, 367 (2010).
17. Kolodkin, A. N. et al. Design principles of nuclear receptor signaling: how complex networking improves signal transduction. Mol. Sys. Biol. 6, 446 (2010).
18. Rigaud, G., Roux, J., Pictet, R. & Grange, T. In vivo footprinting of rat TAT gene-dynamic interplay between the glucocorticoid receptor and a liver-specific factor. Cell 67, 977-986 (1991). (Pubitemid 121001511)
19. Plant, N. The human cytochrome P450 3A sub-family: transcriptional regulation, inter-individual variation and interaction networks. Biochim. et Biophys. Acta-Gen. Subjects 1770, 478-488 2007. (Pubitemid 46136752)
20. El-Sankary, W., Plant, N. & Gibson, G. Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors. Drug Metab. Dispos. 28, 493-496 (2000). (Pubitemid 30238506)
21. Bombail, V., Taylor, K., Gibson, G. & Plant, N. Role of Sp1, C/EBPa, HNF3 and PXR in the basal and xenobiotic-mediated regulation of the CYP3A4 gene. Drug Metab. Dispos. 32, 525-535 (2004). (Pubitemid 38535031)
22. Pan, D., Kocherginsky, M. & Conzen, S. D. Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Res. 71, 6360-6370 (2011).
23. Polman, J. A. E. et al. A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells. BMC Neurosci. 13, 118 (2012).
24. Huizenga, N. et al. Decreased ligand affinity rather than glucocorticoid receptor down-regulation in patients with endogenous Cushing's syndrome. Eur. J. Endocrinol. 142, 472-476 (2000). (Pubitemid 30341178)
25. El-Sankary, W., Bombail, V., Gibson, G. G. & Plant, N. Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: dna interaction distinct from the pregnane X receptor response element. Drug Metab. Dispos. 30, 1029-1034 (2002).
26. Bertilsson, G. et al. Identification of a human nuclear receptor defines a new signalling pathway for CYP3A induction. PNAS 95, 12208-12213 (1998). (Pubitemid 28483744)
27. Blumberg, B. et al. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes and Development 12, 3195-3205 (1998). (Pubitemid 28496264)
28. Kliewer, S. A. et al. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92, 73-82 (1998). (Pubitemid 28053299)
29. Handschin, C. et al. The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals. Nucl. Receptors 2, 7 (2004).
30. El-Sankary, W., Gibson, G. G., Ayrton, A. & Plant, N. Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers. Drug Metab. Dispos. 29, 1499-1504 (2001). (Pubitemid 33000699)
31. Wada, T., Gao, J. & Xie, W. PXR and CAR in energy metabolism. Trends Endocrinol. Metab. 20, 273-279 (2009).
32. Handschin, C. & Meyer, U. A. Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Arch. Biochem. Biophys. 433, 387-396 (2005). (Pubitemid 39592793)
33. Madan, A. et al. Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab. Dispos. 31, 421-431 (2003). (Pubitemid 36378519)
34. Munck, A., Guyre, P. M. & Holbrook, N. J. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr. Rev. 5, 25-44 (1984).
35. Anagnostis, P., Athyros, V. G., Tziomalos, K., Karagiannis, A. & Mikhailidis, D. P. The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis. J. Clin. Endocr. Metab. 94, 2692-2701 (2009).
36. Sher, L. Daily hassles, cortisol, and the pathogenesis of depression. Med. Hypotheses 62, 198-202 (2004). (Pubitemid 38253383)
37. Masson, M. J. et al. Pathologic role of stressed-induced glucocorticoids in drug-induced liver injury in mice. Biochem. Biophys. Res. Commun. 397, 453-458 (2010).
38. Kirschbaum, C. et al. Persistent high cortisol responses to repeated psychological stress in a subpopulation of healthy-men. Psychosom. Med. 57, 468-474 (1995).
39. Golier, J. A., Schmeidler, J., Legge, J. & Yehuda, R. Twenty-four hour plasma cortisol and adrenocorticotropic hormone in Gulf War Veterans: relationships to posttraumatic stress disorder and health symptoms. Biol. Psychiatry 62, 1175-1178 (2007). (Pubitemid 350029726)
40. Hoops, S. et al. COPASI-a COmplex PAthway SImulator. Bioinformatics 22, 3067-3074 (2006).