Decreased ligand affinity rather than glucocorticoid receptor down-regulation in patients with endogenous Cushing's syndrome

European Journal of Endocrinology

Volumn 142, Issue 5, 2000, Pages 472-476

  Huizenga, Nannette A T M ^a   De Herder, Wouter W ^a   Koper, Jan W ^a   De Lange, Pieter ^a   Lely, Aart Jan V D ^a   Brinkmann, Albert O ^a   De Jong, Frank H ^a   Lamberts, Steven W J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; LIGAND;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CUSHING SYNDROME; DEXAMETHASONE SUPPRESSION TEST; FEMALE; HUMAN; HUMAN CELL; HYDROCORTISONE BLOOD LEVEL; LIGAND BINDING; MALE; MONONUCLEAR CELL; PATHOGENESIS; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; REMISSION;

EID: 0034083030     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1420472     Document Type: Article

References (19)

1. Munck A & Guyre PM. Glucocorticoid physiology, pharmacology and stress. In Steroid Hormone Resistance: Mechanism and Clinical Aspects. Advances in Experimental Medicine and Biology, vol 196. pp 81-96. Eds GP Chrousos. DL Loriaux & MB Lipsett. New York: Plenum Press, 1986.
2. Chrousos GP. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. New England Journal of Medicine 1995 322 1351-1362.
3. Bamberger CM, Schulte HM & Chrousos GP. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocrine Reviews 1995 17 245-261.
4. Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988 240 889-892.
5. Giguere V, Hollenberg SM, Rosenfeld MG & Evans RM. Functional domains of the human glucocorticoid receptor. Cell 1985 46 645-652.
6. Brönnegård M. Steroid receptor number, individual variation and downregulation by treatment. American Journal of Respiratory and Critical Care Medicine 1996 154 528-533.
7. Silvia CM, Powell-Oliver FE, Jewell CM, Sar M, Allgod VE & Cidlowski JA. Regulation of the human glucocorticoid receptor by long-term and chronic treatment with glucocorticoids. Steroids 1994 59 456-442.
8. Knutsson U, Stierna P. Carlstedt-Duke J, Carlström K, Marcus C & Brönnegård M. Effects of intranasal glucocorticoids on endogenous glucocorticoid peripheral and central function. Journal of Endocrinology 1995 144 301-310.
9. Molijn GJ, Koper JW, van Uffelen CJC, de Jong FH, Brinkmann AO, Bruining HA et al. Temperature induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leukocyte in patients with sepsis or septic shock. Clinical Endocrinology 1995 43 197-203.
10. Scatchard G. The attractions of proteins for small molecules and ions. Annals of the New York Academy of Sciences 1949 51 660-672.
11. Gehring U, Mugele K & Ulrich J. Cellular receptor levels and glucocorticoid responsiveness of lymphoma cells. Molecular and Cellular Endocrinology 1984 36 107-112.
12. Vanderblid JN, Miesfeld R & Yamamoto KR. Intracellular receptor concentration limits glucocorticoid-dependent enhancer activity. Molecular Endocrinology 1987 1 68-76.
13. Dong Y, Poelinger L, Gustafsson JA & Okret S 1988 Regulation of glucocorticoid receptor expression: evidence for transcriptional and posttranslational mechanisms. Molecular Endocrinology 1988 2 1256-1264.
14. Okret S, Dong Y, Brönnegård M & Gustafsson JA. Regulation of glucocorticoid receptor expression. Biochimie 1991 73 51-59.
15. Burnstein KL, Bellingham DL, Jewell CM, Powell-Oliver FE & Cidlowski JA. Autoregulation of the glucocorticoid receptor gene expression. Steroids 1991 56 52-58.
16. Hurley DM, Accili D, Stratakis CA, Karl M, Vamvakopoulos N, Rorer E et al. Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance. Journal of Clinical Investigation 1991 87 680-686.
17. Malchoff DM, Brufsky A, Reardon G, McDermott P, Javier EC, Bergh CH et al. A mutation of the glucocorticoid receptor in primary curtisol resistance. Journal of Clinical Investigation 1993 91 1918-1925.
18. Karl M, Lamberts SWJ, Koper JW, Katz A, Huizenga NATM, Kino T et al. Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation. Proceedings of the Association of American Physicians 108 296-307.
19. Karl M, Lamberts SWJ, Detera-Wadleigh SD, Enico IJ. Stratakis CA, Hurley DM et al. Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene. Journal of Clinical Endocrinology and Metabolism 1993 76 683-689.