Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: Effects of dose, route, and diet

Toxicological Sciences

Volumn 88, Issue 2, 2005, Pages 340-345

  Bissahoyo, Anika ^a,b   Pearsall, R Scott ^b   Hanlon, Kathleen ^b   Amann, Vicky ^c   Hicks, Donna ^c   Godfrey, Virginia L ^b   Threadgill, David W ^a,b,c  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Azoxymethane; Colorectal tumorigenesis; Dose curve; Genetic susceptibility

Indexed keywords

AZOXYMETHANE; TUMOR PROMOTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; COLORECTAL TUMOR; CONTROLLED STUDY; DIET; FEMALE; HEREDITY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; SEX DIFFERENCE; STANDARDIZATION; STRAIN DIFFERENCE; TUMOR PROMOTION;

ADENOCARCINOMA; ANIMALS; AZOXYMETHANE; CARCINOGENS; COLON; COLORECTAL NEOPLASMS; CROSSES, GENETIC; DIET; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; PREGNANCY; RESEARCH DESIGN; SPECIES SPECIFICITY;

ANIMALIA; RODENTIA;

EID: 27944437061     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfi313     Document Type: Article

References (16)

1. American Cancer Society. (2004). Cancer Statistics.
2. Chang, W. W. (1978). Histogenesis of symmetrical 1,2-dimethylhydrazine-induced neoplasms of the colon in the mouse. J. Natl. Cancer Inst. 60, 1405-1418.
3. Demant, P. (2003). Cancer susceptibility in the mouse: Genetics, biology and implications for human cancer. Nat. Rev. Genet. 4, 721-734.
4. DiGiovanni, J. (1997). Genetic determinants of cancer susceptibility. In Comprehensive Toxicology: Chemical Carcinogens and Anticarcinogens (G. T. Bowden and S. M. Fischer, Eds.), Vol. 12, pp. 425-451. Pergamon Press, New York.
5. Diwan, B. A., and Blackman, K. E. (1980). Differential susceptibility of 3 sublines of C57BL/6 mice to the induction of colorectal tumors by 1,2-dimethylhydrazine. Cancer Lett. 9, 111-115.
6. Druckrey, E. (1970). Production of colonic carcinomas by 1,2-dialkylhydrazines and azoxyalkanes. In Carcinoma of the Colon and Antecedent Epithelium (W. Burdette, Ed.), pp. 267-279. W. J. Thomas Books, Springfield.
7. Evans, J. T., Hauschka, T. S., and Mittelman, A. (1974). Differential susceptibility of four mouse strains to induction of multiple large-bowel neoplasms by 1,2-dimethylhydrazine. J. Natl. Cancer Inst. 52, 999-1000.
8. Ju, J., Liu, Y., Hong, J., Huang, M. T., Conney, A. H., and Yang, C. S. (2003). Effects of green tea and high-fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane-induced colon carcinogenesis mouse model. Nutr. Cancer 46, 172-178.
9. Kinzler, K. W., and Vogelstein, B. (1996). Lessons from hereditary colorectal cancer. Cell 87, 159-170.
10. Matkowskyj, K. A., Marrero, J. A., Carroll, R. E., Danilkovich, A. V., Green, R. M., and Benya, R. V. (1999). Azoxymethane-induced fulminant hepatic failure in C57BL/6J mice: Characterization of a new animal model. Am. J. Physiol. 277, 455-462.
11. Matsubara, K., Komatsu, S., Oka, T., and Kato, N. (2003). Vitamin B6-mediated suppression of colon tumorigenesis, cell proliferation, and angiogenesis. J. Nutr. Biochem. 14, 246-250.
12. Miller, J. A. (1964). Comments on chemistry of cycads. Fed. Proc. 23, 1361-1362.
13. Nambiar, P. R.. Girnun, G., Lillo, N. A., Guda, K., Whiteley, H. E., and Rosenberg, D. W. (2003). Preliminary analysis of azoxymethane induced colon tumors in inbred mice commonly used as transgenic/knockout progenitors. Int. J. Oncol. 22, 145-150.
14. Papanikolaou, A., Wang, Q. S., Delker, D. A., and Rosenberg, D. W. (1998). Azoxymethane-induced colon tumors and aberrant crypt foci in mice of different genetic susceptibility. Cancer Lett. 130, 29-34.
15. Rodier, P. M., Kates, B., White, W. A., and Muhs, A. (1991). Effects of prenatal exposure to methylazoxymethanol (MAM) on brain weight, hypothalamic cell number, pituitary structure, and postnatal growth in the rat. Teraology 43, 241-251.
16. Weisburger, J. H. (1971). Colon carcinogens: Their metabolism and model of action. Cancer 28, 60-70.