Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway

American Journal of Reproductive Immunology

Volumn 62, Issue 2, 2009, Pages 96-111

  Mulla, Melissa J ^a   Brosens, Jan J ^b   Chamley, Larry W ^c   Giles, Ian ^d   Pericleous, Charis ^d   Rahman, Anisur ^d   Joyce, Shawna K ^a   Panda, Britta ^e   Paidas, Michael J ^a   Abrahams, Vikki M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e BRIDGEPORT HOSPITAL   (United States)

Author keywords

Apoptosis; Autoantibodies; Human; Inflammation; Toll like receptor

Indexed keywords

BETA2 GLYCOPROTEIN 1; BETA2 GLYCOPROTEIN 1 ANTIBODY; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEPARIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHOLIPID ANTIBODY; RANTES; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL DEATH; CELL FUNCTION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FIRST TRIMESTER PREGNANCY; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TROPHOBLAST;

ADULT; AGED; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIBODIES, MONOCLONAL; ANTIPHOSPHOLIPID SYNDROME; APOPTOSIS; BETA 2-GLYCOPROTEIN I; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; CHEMOKINE CXCL1; CYTOKINES; FEMALE; HEPARIN; HUMANS; INFLAMMATION; MIDDLE AGED; MYELOID DIFFERENTIATION FACTOR 88; PREGNANCY; PREGNANCY TRIMESTER, FIRST; TOLL-LIKE RECEPTOR 4; TROPHOBLASTS;

EID: 67650651969     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2009.00717.x     Document Type: Article

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