GDKV-induced antiphospholipid antibodies enhance thrombosis and activate endothelial cells in vivo and in vitro

Journal of Immunology

Volumn 163, Issue 5, 1999, Pages 2922-2927

  Gharavi, Azzudin E ^a   Pierangeli, Silvia S ^a   Colden Stanfield, Margaret ^a   Liu, Xiao Wei ^a   Espinola, Ricardo G ^a   Harris, E Nigel ^a  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; PHOSPHOLIPID ANTIBODY; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; MICROCIRCULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTOPENIA; THROMBOSIS;

ADJUVANTS, IMMUNOLOGIC; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, ANTIPHOSPHOLIPID; BETA 2-GLYCOPROTEIN I; BINDING SITES; CELL ADHESION MOLECULES; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FEMALE; GLYCOPROTEINS; HUMANS; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PHOSPHOLIPIDS; THROMBOSIS;

EID: 0033197971     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Gharavi, A. E., and W. A. Wilson. 1997. Antiphospholipid antibodies. In: Dubois' Lupus Erythematosus. 5th Ed. D. J. Wallace and B. H. Hahn, eds. Williams and Wilkins, Baltimore, pp. 471.
2. Sammaritano, L. R., A. E. Gharavi, and M. D. Lockshin. 1990. Antiphospholipid antibody: immunologic and clinical aspects. Semin. Arthritis Rheum. 20: 81.
3. Harris, E. N., A. E. Gharavi, and G. R. V. Hughes. 1985. Antiphospholipid antibodies. Clin. Rheum. Dis. 11:591.
4. Gharavi, A. E., E. N. Harris, R. A. Asherson, and G. R. V. Hughes. 1987. Anticardiolipin antibodies: isotype distribution and phospholipid specificity. Ann. Rheum. Dis. 46:1.
5. Harris, E. N., A. E. Gharavi, M. L. Boey, M. B. Patel, C. G. Mackworth-Young, S. Loizou, and G. R. V. Hughes. 1983. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 2:1211.
6. Marcus, D. M., and G. E. Schwarting. 1976. Immunological properties of glycoproteins and phospholipids. Adv. Immunol. 23:203.
7. Alving, C. R. 1986. Antibodies to liposomes, phospholipids, and phosphate esters. Chem. Phys. Lipids 40:303.
8. Inoue, K., and S. Nujima. 1967. Immunochemical studies of phospholipids. I. Reactivity of various synthetic cardiolipin derivatives with Wasserman antibody. Biochim. Biophys. Acta 144:409.
9. Rauch, J., H. Tannenbaum, B. D. Stollar, and R. S. Schwartz. 1984. Monoclonal anticardiolipin antibodies bind to DNA. Eur. J. Immunol. 14:529.
10. Igarashi, K., M. Umeda, L. Tokita, K. Soo Nam, and K. Inoue. 1991. Effective induction of antiphospholipid and lupus anticoagulant in normal mouse. Thromb. Res. 61:135.
11. Schuster, B. G., M. Neidig, M., B. M. Alving, and C. R. Alving. 1979. Producing antibodies against phosphocholine, phosphatidylcholine, and sphingomyelin and lipid A by injection of liposomes containing lipid A. J. Immunol. 122:900.
12. 2 glycoprotein I (apolipoptotein H). J. Clin. Invest. 90: 1105.
13. 2 glycoprotein I (apolipoprotein H). Proc. Natl. Acad. Sci. USA 87:4120.
14. Galli, M., P. Comfurius, H. C. Hemker, M. H. Debaets, P. J. C. van Breda-Vreisman, T. Barbui, R. F. A. Zwaal, and E. M. Bevers. 1990. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet 335:1544.
15. Matsuura, H., T. Igarashi, M. Fujimoto, K. Ichikawa, and T. Koike. 1990. Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet 336:177.
16. 2 glycoprotein I-induced antiphospholipid antibodies. J. Lab. Clin. Med. 125:775.
17. 2 glycoprotein I or anticardiolipin antibodies alone. Clin. Exp. Immunol. 78:233.
18. 2-glycoprotein I) induces experimental antiphospholipid antibody syndrome in naïve mice. J. Autoimmun. 7:441.
19. 2 glycoprotein I. Clin. Exp. Immunol. 101:78.
20. 2 GPI. Am. J. Reprod. Immunol. 37: 118.
21. 2glycoprotein 1 and human IgG antiphospholipid antibodies. Circulation 94:1746.
22. 2GPI) alone. Lupus 7:341.
23. 2 glycoprotein I contains a phospholipid binding site (Cys 281-Lys288) and a region recognized by anticardiolipin antibodies. J. Immunol. 152:653.
24. 2 glycoprotein I structures recognized by anticardiolipin antibodies. Lupus 3:313.
25. Kohler, G., and C. Milstein 1975. Continuous culture of fused cells secreting antibody to predefined specificity. Nature 256: 495.
26. Stockmans, F., H. Deckmyn, J. Gruwez, J. Vermylen, and R. Acland. 1991. Continuous quantitative monitoring of mural, platelet-dependent thrombus kinetics in the crushed rat femoral vein. Thromb. Haemostasis 65:425.
27. Pierangeli, S. S., J. H. Barker, D. Stikovac, D. Ackerman, G. Anderson, J. Barquinero, R. Acland, and E. N. Harris. 1994. Effect of human IgG antiphospholipid antibodies on an in vivo thrombosis model in mice. Thromb. Haemostasis 71:670.
28. Pierangeli, S. S., X. W. Liu, G. H. Anderson, J. H. Barker, and E. N. Harris. 1995. Induction of thrombosis in a mouse model by IgG, IgM and IgA immunoglobulins from patients with the antiphospholipid syndrome. Thromb. Haemostasis 74:1361.
29. Peter, F. W., D. A. Schuschke, W. Z. Wang, G. H. Anderson, R. J. P. M. Franken, J. M. Gu, S. S. Pierangeli, and J. H. Barker. 1998. Do leukocytes contribute to impaired microvascular tissue perfusion after arterial repair? Microsurgery 18:23.
30. Pierangeli, S. S., M. Colden-Stanfield, X. Liu, J. H. Barker, G. L. Anderson and E. N. Harris. 1999. Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation 99:1997.
31. Colden-Stanfield M., D. Radcliffe, E. B. Cramer, and E. K. Gallin. 1993. Characterization of influenza-virus-induced luekocyte adherence to human umbilical vein endothelial cell monolayers. J. Immunol. 151:310.
32. Colden-Stanfield M., J. F. Kalinich and E. K. Gallin. 1994. Ionizing radiation increases endothelial and epithelial cell production of influenza virus and leukocyte adherence. J. Immunol. 153:5222.
33. Simantov, R., I. M. LaSala, S. K. Lo, A. E. Gharavi, L. R. Sammaritano, J. E. Salmon, and L. R. Silverstein. 1995. Activation of cultured vascular endothelial cells by antiphospholipid antibodies. J. Clin. Invest. 96:2211.
34. Bakimer R., P. Fishman, M. Blank, B. Srednc, M. Djadetti, and Y. Shoenfeld. 1992. Induction of primary APS in mice by immunization with a human monoclonal anticardiolipin antibody (H-3). J. Clin. Invest. 89:1558.
35. Sammaritano, L. R., A. E. Gharavi, and M. D. Lockshin. 1992. Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein. J. Clin. Immunol. 12:27.