Effect of prednisone, aspirin, low molecular weight heparin and intravenous immunoglobulin on outcome of pregnancy in women with antiphospholipid syndrome

Experimental and Therapeutic Medicine

Volumn 5, Issue 1, 2013, Pages 287-291

  Xiao, Jing ^a   Xiong, Jing ^a   Zhu, Fufan ^a   He, Liang ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Antiphospholipid syndrome; Intravenous immunoglobulin; Live birth; Low molecular weight heparin; Obstetric complication

Indexed keywords

ACETYLSALICYLIC ACID; DALTEPARIN; IMMUNOGLOBULIN; PREDNISONE;

ADULT; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BIRTH RATE; BIRTH WEIGHT; CLINICAL TRIAL; COMPREHENSIVE DRUG TREATMENT; DRUG EFFICACY; ECLAMPSIA; FEMALE; FETUS DEATH; FETUS OUTCOME; GESTATIONAL AGE; HUMAN; INTERMETHOD COMPARISON; LIVE BIRTH; LOW DRUG DOSE; MAJOR CLINICAL STUDY; PLACENTA INSUFFICIENCY; PREECLAMPSIA; PREGNANCY OUTCOME; PREMATURE LABOR; SPONTANEOUS ABORTION; STILLBIRTH; THERAPY; TRADITIONAL DRUG TREATMENT;

EID: 84869414418     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2012.743     Document Type: Article

References (15)

1. Miyakis S, Lockshin MD, Atsumi T, et al: International consensus statement on an update of the classifcation criteria for defnite antiphospholipid syndrome (APS). J Thromb Haemost 4: 295-306, 2006.
2. Meroni PL, Borghi MO, Raschi E and Tedesco F: Pathogenesis of antiphospholipid syndrome: understanding the antibodies. Nat Rev Rheumatol 7: 330-339, 2011.
3. Soltesz P, Der H, Veres K, et al: Immunological features of primary anti-phospholipid syndrome in connection with endo-thelial dysfunction. Rheumatology (Oxford) 47: 1628-1634, 2008.
4. Silveira LH, Hubble CL, Jara LJ, et al: Prevention of anticar-diolipin antibody-related pregnancy losses with prednisone and aspirin. Am J Med 93: 403-411, 1992.
5. Cowchock FS, Reece EA, Balaban D, Branch DW and Plouffe L: Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomized trial comparing prednisone with low-dose heparin treatment. Am J Obstet Gynecol 166: 1318-1323, 1992.
6. Ghazeeri GS and Kutteh WH: Immunological testing and treatment in reproduction: frequency assessment of practice patterns at assisted reproduction clinics in the USA and Australia. Hum Reprod 16: 2130-2135, 2001.
7. Pierangeli SS, Espinola R, Liu X, Harris EN and Salmon JE: Identifcation of an Fc gamma receptor-independent mechanism by which intravenous immunoglobulin ameliorates antiphos-pholipid antibody-induced thrombogenic phenotype. Arthritis Rheum 44: 876-883, 2001.
8. Branch DW, Peaceman AM, Druzin M, et al: A multicenter, placebo-controlled pilot study of intravenous immune globulin treatment of antiphospholipid syndrome during pregnancy. The Pregnancy Loss Study Group. Am J Obstet Gynecol 182: 122-127, 2000.
9. Sebire NJ, Fox H, Backos M, Rai R, Paterson C and Regan L: Defective endovascular trophoblast invasion in primary antiphospholipid antibody syndrome-associated early pregnancy failure. Hum Reprod 17: 1067-1071, 2002.
10. Alalaf S: Bemiparin versus low dose aspirin for management of recurrent early pregnancy losses due to antiphospholipd antibody syndrome. Arch Gynecol Obstet 285: 641-647, 2012.
11. Stephenson MD, Ballem PJ, Tsang P, et al: Treatment of antiphos-pholipid antibody syndrome (APS) in pregnancy: a randomized pilot trial comparing low molecular weight heparin to unfrac-tionated heparin. J Obstet Gynaecol Can 26: 729-734, 2004.
12. Salmon JE and Girardi G: Theodore E. Woodward Award: antiphospholipid syndrome revisited: a disorder initiated by infammation. Trans Am Clin Climatol Assoc 118: 99-114, 2007.
13. Hochart H, Jenkins PV, Smith OP and White B: Low-molecular weight and unfractionated heparins induce a downregulation of infammation: decreased levels of proinfammatory cytokines and nuclear factor-kappaB in LPS-stimulated human monocytes. Br J Haematol 133: 62-67, 2006.
14. Wang L, Brown JR, Varki A and Esko JD: Heparin's anti-infammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. J Clin Invest 110: 127-136, 2002.
15. Guerin J, Sheng Y, Reddel S, Iverson GM, Chapman MG and Krilis SA: Heparin inhibits the binding of beta 2-glycoprotein I to phospholipids and promotes the plasmin-mediated inacti-vation of this blood protein. Elucidation of the consequences of the two biological events in patients with the anti-phospholipid syndrome. J Biol Chem 277: 2644-2649, 2002.