-
1
-
-
84875814329
-
AACR Cancer Progress Report 2012
-
Cantley LC, Dalton WS, DuBois RN, Finn OJ, Futreal PA, Golub TR, Hait WN, Lozano G, Maris JM, Nelson WG, Sawyers CL, Schreiber SL, Spitz MR, Steeg PS. AACR Cancer Progress Report 2012. Clin Cancer Res 2012, 18(21 Suppl):S1-100.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.21 SUPPL.
-
-
Cantley, L.C.1
Dalton, W.S.2
DuBois, R.N.3
Finn, O.J.4
Futreal, P.A.5
Golub, T.R.6
Hait, W.N.7
Lozano, G.8
Maris, J.M.9
Nelson, W.G.10
Sawyers, C.L.11
Schreiber, S.L.12
Spitz, M.R.13
Steeg, P.S.14
-
2
-
-
79960985571
-
Structure-based druggability assessment-identifying suitable targets for small molecule therapeutics
-
10.1016/j.cbpa.2011.05.020, 21704549
-
Fauman EB, Rai BK, Huang ES. Structure-based druggability assessment-identifying suitable targets for small molecule therapeutics. Curr Opin Chem Biol 2011, 15:463-468. 10.1016/j.cbpa.2011.05.020, 21704549.
-
(2011)
Curr Opin Chem Biol
, vol.15
, pp. 463-468
-
-
Fauman, E.B.1
Rai, B.K.2
Huang, E.S.3
-
3
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
10.1038/35888, 9486653
-
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391:806-811. 10.1038/35888, 9486653.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
4
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
10.1038/35078107, 11373684
-
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001, 411:494-498. 10.1038/35078107, 11373684.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
5
-
-
38849098442
-
Cancer proliferation gene discovery through functional genomics
-
10.1126/science.1149200, 2981870, 18239126
-
Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ. Cancer proliferation gene discovery through functional genomics. Science 2008, 319:620-624. 10.1126/science.1149200, 2981870, 18239126.
-
(2008)
Science
, vol.319
, pp. 620-624
-
-
Schlabach, M.R.1
Luo, J.2
Solimini, N.L.3
Hu, G.4
Xu, Q.5
Li, M.Z.6
Zhao, Z.7
Smogorzewska, A.8
Sowa, M.E.9
Ang, X.L.10
Westbrook, T.F.11
Liang, A.C.12
Chang, K.13
Hackett, J.A.14
Harper, J.W.15
Hannon, G.J.16
Elledge, S.J.17
-
6
-
-
36248962105
-
The genomic landscapes of human breast and colorectal cancers
-
10.1126/science.1145720, 17932254
-
Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R, Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, Dawson D, Shipitsin M, Willson JK, Sukumar S, Polyak K, Park BH, Pethiyagoda CL, Pant PV, et al. The genomic landscapes of human breast and colorectal cancers. Science 2007, 318:1108-1113. 10.1126/science.1145720, 17932254.
-
(2007)
Science
, vol.318
, pp. 1108-1113
-
-
Wood, L.D.1
Parsons, D.W.2
Jones, S.3
Lin, J.4
Sjoblom, T.5
Leary, R.J.6
Shen, D.7
Boca, S.M.8
Barber, T.9
Ptak, J.10
Silliman, N.11
Szabo, S.12
Dezso, Z.13
Ustyanksky, V.14
Nikolskaya, T.15
Nikolsky, Y.16
Karchin, R.17
Wilson, P.A.18
Kaminker, J.S.19
Zhang, Z.20
Croshaw, R.21
Willis, J.22
Dawson, D.23
Shipitsin, M.24
Willson, J.K.25
Sukumar, S.26
Polyak, K.27
Park, B.H.28
Pethiyagoda, C.L.29
Pant, P.V.30
more..
-
7
-
-
35148885729
-
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
-
10.1016/j.ccr.2007.08.030, 17936563
-
Berns K, Horlings HM, Hennessy BT, Madiredjo M, Hijmans EM, Beelen K, Linn SC, Gonzalez-Angulo AM, Stemke-Hale K, Hauptmann M, Beijersbergen RL, Mills GB, van de Vijver MJ, Bernards R. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 2007, 12:395-402. 10.1016/j.ccr.2007.08.030, 17936563.
-
(2007)
Cancer Cell
, vol.12
, pp. 395-402
-
-
Berns, K.1
Horlings, H.M.2
Hennessy, B.T.3
Madiredjo, M.4
Hijmans, E.M.5
Beelen, K.6
Linn, S.C.7
Gonzalez-Angulo, A.M.8
Stemke-Hale, K.9
Hauptmann, M.10
Beijersbergen, R.L.11
Mills, G.B.12
van de Vijver, M.J.13
Bernards, R.14
-
8
-
-
20044395613
-
RAS is regulated by the let-7 microRNA family
-
10.1016/j.cell.2005.01.014, 15766527
-
Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ. RAS is regulated by the let-7 microRNA family. Cell 2005, 120:635-647. 10.1016/j.cell.2005.01.014, 15766527.
-
(2005)
Cell
, vol.120
, pp. 635-647
-
-
Johnson, S.M.1
Grosshans, H.2
Shingara, J.3
Byrom, M.4
Jarvis, R.5
Cheng, A.6
Labourier, E.7
Reinert, K.L.8
Brown, D.9
Slack, F.J.10
-
9
-
-
84862638243
-
Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN
-
10.1371/journal.pone.0039520, 3382593, 22761812
-
Han M, Liu M, Wang Y, Chen X, Xu J, Sun Y, Zhao L, Qu H, Fan Y, Wu C. Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN. PLoS One 2012, 7:e39520. 10.1371/journal.pone.0039520, 3382593, 22761812.
-
(2012)
PLoS One
, vol.7
-
-
Han, M.1
Liu, M.2
Wang, Y.3
Chen, X.4
Xu, J.5
Sun, Y.6
Zhao, L.7
Qu, H.8
Fan, Y.9
Wu, C.10
-
10
-
-
77953898940
-
A microRNA targeting dicer for metastasis control
-
10.1016/j.cell.2010.05.017, 20603000
-
Martello G, Rosato A, Ferrari F, Manfrin A, Cordenonsi M, Dupont S, Enzo E, Guzzardo V, Rondina M, Spruce T, Parenti AR, Daidone MG, Bicciato S, Piccolo S. A microRNA targeting dicer for metastasis control. Cell 2010, 141:1195-1207. 10.1016/j.cell.2010.05.017, 20603000.
-
(2010)
Cell
, vol.141
, pp. 1195-1207
-
-
Martello, G.1
Rosato, A.2
Ferrari, F.3
Manfrin, A.4
Cordenonsi, M.5
Dupont, S.6
Enzo, E.7
Guzzardo, V.8
Rondina, M.9
Spruce, T.10
Parenti, A.R.11
Daidone, M.G.12
Bicciato, S.13
Piccolo, S.14
-
11
-
-
65549110881
-
MicroRNA-205 regulates HER3 in human breast cancer
-
10.1158/0008-5472.CAN-08-2920, 19276373
-
Iorio MV, Casalini P, Piovan C, Di Leva G, Merlo A, Triulzi T, Menard S, Croce CM, Tagliabue E. microRNA-205 regulates HER3 in human breast cancer. Cancer Res 2009, 69:2195-2200. 10.1158/0008-5472.CAN-08-2920, 19276373.
-
(2009)
Cancer Res
, vol.69
, pp. 2195-2200
-
-
Iorio, M.V.1
Casalini, P.2
Piovan, C.3
Di Leva, G.4
Merlo, A.5
Triulzi, T.6
Menard, S.7
Croce, C.M.8
Tagliabue, E.9
-
12
-
-
80051571107
-
ErbB2 down-regulates microRNA-205 in breast cancer
-
10.1016/j.bbrc.2011.07.033, 21787752
-
Adachi R, Horiuchi S, Sakurazawa Y, Hasegawa T, Sato K, Sakamaki T. ErbB2 down-regulates microRNA-205 in breast cancer. Biochem Biophys Res Commun 2011, 411:804-808. 10.1016/j.bbrc.2011.07.033, 21787752.
-
(2011)
Biochem Biophys Res Commun
, vol.411
, pp. 804-808
-
-
Adachi, R.1
Horiuchi, S.2
Sakurazawa, Y.3
Hasegawa, T.4
Sato, K.5
Sakamaki, T.6
-
13
-
-
77949632782
-
Frontiers in cancer nanomedicine: directing mass transport through biological barriers
-
10.1016/j.tibtech.2009.12.007, 2843761, 20079548
-
Ferrari M. Frontiers in cancer nanomedicine: directing mass transport through biological barriers. Trends Biotechnol 2010, 28:181-188. 10.1016/j.tibtech.2009.12.007, 2843761, 20079548.
-
(2010)
Trends Biotechnol
, vol.28
, pp. 181-188
-
-
Ferrari, M.1
-
14
-
-
11144357506
-
Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer
-
10.1093/annonc/mdh097, 14998846, CAELYX Breast Cancer Study Group
-
O'Brien ME, Wigler N, Inbar M, Rosso R, Grischke E, Santoro A, Catane R, Kieback DG, Tomczak P, Ackland SP, Orlandi F, Mellars L, Alland L, Tendler C, CAELYX Breast Cancer Study Group Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer. Ann Oncol 2004, 15:440-449. 10.1093/annonc/mdh097, 14998846, CAELYX Breast Cancer Study Group.
-
(2004)
Ann Oncol
, vol.15
, pp. 440-449
-
-
O'Brien, M.E.1
Wigler, N.2
Inbar, M.3
Rosso, R.4
Grischke, E.5
Santoro, A.6
Catane, R.7
Kieback, D.G.8
Tomczak, P.9
Ackland, S.P.10
Orlandi, F.11
Mellars, L.12
Alland, L.13
Tendler, C.14
-
15
-
-
0035282073
-
Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer
-
Batist G, Ramakrishnan G, Rao CS, Chandrasekharan A, Gutheil J, Guthrie T, Shah P, Khojasteh A, Nair MK, Hoelzer K, Tkaczuk K, Park YC, Lee LW. Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer. J Clin Oncol 2001, 19:1444-1454.
-
(2001)
J Clin Oncol
, vol.19
, pp. 1444-1454
-
-
Batist, G.1
Ramakrishnan, G.2
Rao, C.S.3
Chandrasekharan, A.4
Gutheil, J.5
Guthrie, T.6
Shah, P.7
Khojasteh, A.8
Nair, M.K.9
Hoelzer, K.10
Tkaczuk, K.11
Park, Y.C.12
Lee, L.W.13
-
16
-
-
32944482677
-
Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
-
10.1200/JCO.2005.04.937, 16172456
-
Gradishar WJ, Tjulandin S, Davidson N, Shaw H, Desai N, Bhar P, Hawkins M, O'Shaughnessy J. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol 2005, 23:7794-7803. 10.1200/JCO.2005.04.937, 16172456.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7794-7803
-
-
Gradishar, W.J.1
Tjulandin, S.2
Davidson, N.3
Shaw, H.4
Desai, N.5
Bhar, P.6
Hawkins, M.7
O'Shaughnessy, J.8
-
17
-
-
0034993240
-
The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting
-
10.1016/S0065-2571(00)00013-3, 11384745
-
Maeda H. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv Enzyme Regul 2001, 41:189-207. 10.1016/S0065-2571(00)00013-3, 11384745.
-
(2001)
Adv Enzyme Regul
, vol.41
, pp. 189-207
-
-
Maeda, H.1
-
18
-
-
12344312042
-
Cellular abnormalities of blood vessels as targets in cancer
-
10.1016/j.gde.2004.12.005, 15661540
-
Baluk P, Hashizume H, McDonald DM. Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev 2005, 15:102-111. 10.1016/j.gde.2004.12.005, 15661540.
-
(2005)
Curr Opin Genet Dev
, vol.15
, pp. 102-111
-
-
Baluk, P.1
Hashizume, H.2
McDonald, D.M.3
-
19
-
-
39049171058
-
Liposomal nanomedicines
-
10.1517/17425247.5.1.25, 18095927
-
Fenske DB, Cullis PR. Liposomal nanomedicines. Expert Opin Drug Deliv 2008, 5:25-44. 10.1517/17425247.5.1.25, 18095927.
-
(2008)
Expert Opin Drug Deliv
, vol.5
, pp. 25-44
-
-
Fenske, D.B.1
Cullis, P.R.2
-
20
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
10.1038/nature04688, 16565705
-
Zimmermann TS, Lee AC, Akinc A, Bramlage B, Bumcrot D, Fedoruk MN, Harborth J, Heyes JA, Jeffs LB, John M, Judge AD, Lam K, McClintock K, Nechev LV, Palmer LR, Racie T, Rohl I, Seiffert S, Shanmugam S, Sood V, Soutschek J, Toudjarska I, Wheat AJ, Yaworski E, Zedalis W, Koteliansky V, Manoharan M, Vornlocher HP, MacLachlan I. RNAi-mediated gene silencing in non-human primates. Nature 2006, 441:111-114. 10.1038/nature04688, 16565705.
-
(2006)
Nature
, vol.441
, pp. 111-114
-
-
Zimmermann, T.S.1
Lee, A.C.2
Akinc, A.3
Bramlage, B.4
Bumcrot, D.5
Fedoruk, M.N.6
Harborth, J.7
Heyes, J.A.8
Jeffs, L.B.9
John, M.10
Judge, A.D.11
Lam, K.12
McClintock, K.13
Nechev, L.V.14
Palmer, L.R.15
Racie, T.16
Rohl, I.17
Seiffert, S.18
Shanmugam, S.19
Sood, V.20
Soutschek, J.21
Toudjarska, I.22
Wheat, A.J.23
Yaworski, E.24
Zedalis, W.25
Koteliansky, V.26
Manoharan, M.27
Vornlocher, H.P.28
MacLachlan, I.29
more..
-
21
-
-
43049176170
-
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
-
10.1038/nbt1402, 3014085, 18438401
-
Akinc A, Zumbuehl A, Goldberg M, Leshchiner ES, Busini V, Hossain N, Bacallado SA, Nguyen DN, Fuller J, Alvarez R, Borodovsky A, Borland T, Constien R, de Fougerolles A, Dorkin JR, Narayanannair Jayaprakash K, Jayaraman M, John M, Koteliansky V, Manoharan M, Nechev L, Qin J, Racie T, Raitcheva D, Rajeev KG, Sah DW, Soutschek J, Toudjarska I, Vornlocher HP, Zimmermann TS, et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol 2008, 26:561-569. 10.1038/nbt1402, 3014085, 18438401.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 561-569
-
-
Akinc, A.1
Zumbuehl, A.2
Goldberg, M.3
Leshchiner, E.S.4
Busini, V.5
Hossain, N.6
Bacallado, S.A.7
Nguyen, D.N.8
Fuller, J.9
Alvarez, R.10
Borodovsky, A.11
Borland, T.12
Constien, R.13
de Fougerolles, A.14
Dorkin, J.R.15
Narayanannair Jayaprakash, K.16
Jayaraman, M.17
John, M.18
Koteliansky, V.19
Manoharan, M.20
Nechev, L.21
Qin, J.22
Racie, T.23
Raitcheva, D.24
Rajeev, K.G.25
Sah, D.W.26
Soutschek, J.27
Toudjarska, I.28
Vornlocher, H.P.29
Zimmermann, T.S.30
more..
-
22
-
-
79953319793
-
Functional roles of Src and Fgr in ovarian carcinoma
-
10.1158/1078-0432.CCR-10-2081, 3077122, 21300758
-
Kim HS, Han HD, Armaiz-Pena GN, Stone RL, Nam EJ, Lee JW, Shahzad MM, Nick AM, Lee SJ, Roh JW, Nishimura M, Mangala LS, Bottsford-Miller J, Gallick GE, Lopez-Berestein G, Sood AK. Functional roles of Src and Fgr in ovarian carcinoma. Clin Cancer Res 2011, 17:1713-1721. 10.1158/1078-0432.CCR-10-2081, 3077122, 21300758.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1713-1721
-
-
Kim, H.S.1
Han, H.D.2
Armaiz-Pena, G.N.3
Stone, R.L.4
Nam, E.J.5
Lee, J.W.6
Shahzad, M.M.7
Nick, A.M.8
Lee, S.J.9
Roh, J.W.10
Nishimura, M.11
Mangala, L.S.12
Bottsford-Miller, J.13
Gallick, G.E.14
Lopez-Berestein, G.15
Sood, A.K.16
-
23
-
-
84859461033
-
Inhibition of p42 MAPK using a nonviral vectordelivered siRNA potentiates the antitumor effect of metformin in prostate cancer cells
-
10.2217/nnm.11.61, 21995500
-
Monteagudo S, Perez-Martinez FC, Perez-Carrion MD, Guerra J, Merino S, Sanchez-Verdu MP, Cena V. Inhibition of p42 MAPK using a nonviral vectordelivered siRNA potentiates the antitumor effect of metformin in prostate cancer cells. Nanomedicine (Lond) 2012, 7:493-506. 10.2217/nnm.11.61, 21995500.
-
(2012)
Nanomedicine (Lond)
, vol.7
, pp. 493-506
-
-
Monteagudo, S.1
Perez-Martinez, F.C.2
Perez-Carrion, M.D.3
Guerra, J.4
Merino, S.5
Sanchez-Verdu, M.P.6
Cena, V.7
-
24
-
-
68849112640
-
Polyethylenimine-based siRNA nanocomplexes reprogram tumorassociated dendritic cells via TLR5 to elicit therapeutic antitumor immunity
-
2719935, 19620771
-
Cubillos-Ruiz JR, Engle X, Scarlett UK, Martinez D, Barber A, Elgueta R, Wang L, Nesbeth Y, Durant Y, Gewirtz AT, Sentman CL, Kedl R, Conejo-Garcia JR. Polyethylenimine-based siRNA nanocomplexes reprogram tumorassociated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. J Clin Invest 2009, 119:2231-2244. 2719935, 19620771.
-
(2009)
J Clin Invest
, vol.119
, pp. 2231-2244
-
-
Cubillos-Ruiz, J.R.1
Engle, X.2
Scarlett, U.K.3
Martinez, D.4
Barber, A.5
Elgueta, R.6
Wang, L.7
Nesbeth, Y.8
Durant, Y.9
Gewirtz, A.T.10
Sentman, C.L.11
Kedl, R.12
Conejo-Garcia, J.R.13
-
25
-
-
84555202691
-
P-glycoprotein silencing with siRNA delivered by DOPE-modified PEI overcomes doxorubicin resistance in breast cancer cells
-
10.2217/nnm.11.93, 3422569, 22191778
-
Navarro G, Sawant RR, Biswas S, Essex S, Tros de Ilarduya C, Torchilin VP. P-glycoprotein silencing with siRNA delivered by DOPE-modified PEI overcomes doxorubicin resistance in breast cancer cells. Nanomedicine (Lond) 2012, 7:65-78. 10.2217/nnm.11.93, 3422569, 22191778.
-
(2012)
Nanomedicine (Lond)
, vol.7
, pp. 65-78
-
-
Navarro, G.1
Sawant, R.R.2
Biswas, S.3
Essex, S.4
Tros de Ilarduya, C.5
Torchilin, V.P.6
-
26
-
-
84858793517
-
Self-assembled RNA interference microsponges for efficient siRNA delivery
-
10.1038/nmat3253, 22367004
-
Lee JB, Hong J, Bonner DK, Poon Z, Hammond PT. Self-assembled RNA interference microsponges for efficient siRNA delivery. Nat Mater 2012, 11:316-322. 10.1038/nmat3253, 22367004.
-
(2012)
Nat Mater
, vol.11
, pp. 316-322
-
-
Lee, J.B.1
Hong, J.2
Bonner, D.K.3
Poon, Z.4
Hammond, P.T.5
-
27
-
-
84860211700
-
Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis
-
Yao YD, Sun TM, Huang SY, Dou S, Lin L, Chen JN, Ruan JB, Mao CQ, Yu FY, Zeng MS, Zang JY, Liu Q, Su FX, Zhang P, Lieberman J, Wang J, Song E. Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Sci Transl Med 2012, 4:130ra148.
-
(2012)
Sci Transl Med
, vol.4
-
-
Yao, Y.D.1
Sun, T.M.2
Huang, S.Y.3
Dou, S.4
Lin, L.5
Chen, J.N.6
Ruan, J.B.7
Mao, C.Q.8
Yu, F.Y.9
Zeng, M.S.10
Zang, J.Y.11
Liu, Q.12
Su, F.X.13
Zhang, P.14
Lieberman, J.15
Wang, J.16
Song, E.17
-
28
-
-
65649085603
-
Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice
-
10.1172/JCI37515, 2648695, 19229107
-
Judge AD, Robbins M, Tavakoli I, Levi J, Hu L, Fronda A, Ambegia E, McClintock K, MacLachlan I. Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice. J Clin Invest 2009, 119:661-673. 10.1172/JCI37515, 2648695, 19229107.
-
(2009)
J Clin Invest
, vol.119
, pp. 661-673
-
-
Judge, A.D.1
Robbins, M.2
Tavakoli, I.3
Levi, J.4
Hu, L.5
Fronda, A.6
Ambegia, E.7
McClintock, K.8
MacLachlan, I.9
-
29
-
-
76349111051
-
Rational design of cationic lipids for siRNA delivery
-
10.1038/nbt.1602, 20081866
-
Semple SC, Akinc A, Chen J, Sandhu AP, Mui BL, Cho CK, Sah DW, Stebbing D, Crosley EJ, Yaworski E, Hafez IM, Dorkin JR, Qin J, Lam K, Rajeev KG, Wong KF, Jeffs LB, Nechev L, Eisenhardt ML, Jayaraman M, Kazem M, Maier MA, Srinivasulu M, Weinstein MJ, Chen Q, Alvarez R, Barros SA, De S, Klimuk SK, Borland T, Kosovrasti V, et al. Rational design of cationic lipids for siRNA delivery. Nat Biotechnol 2010, 28:172-176. 10.1038/nbt.1602, 20081866.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 172-176
-
-
Semple, S.C.1
Akinc, A.2
Chen, J.3
Sandhu, A.P.4
Mui, B.L.5
Cho, C.K.6
Sah, D.W.7
Stebbing, D.8
Crosley, E.J.9
Yaworski, E.10
Hafez, I.M.11
Dorkin, J.R.12
Qin, J.13
Lam, K.14
Rajeev, K.G.15
Wong, K.F.16
Jeffs, L.B.17
Nechev, L.18
Eisenhardt, M.L.19
Jayaraman, M.20
Kazem, M.21
Maier, M.A.22
Srinivasulu, M.23
Weinstein, M.J.24
Chen, Q.25
Alvarez, R.26
Barros, S.A.27
De, S.28
Klimuk, S.K.29
Borland, T.30
Kosovrasti, V.31
more..
-
30
-
-
33746883220
-
A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium
-
10.1038/sj.gt.3302777, 16625243
-
Santel A, Aleku M, Keil O, Endruschat J, Esche V, Fisch G, Dames S, Loffler K, Fechtner M, Arnold W, Giese K, Klippel A, Kaufmann J. A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium. Gene Ther 2006, 13:1222-1234. 10.1038/sj.gt.3302777, 16625243.
-
(2006)
Gene Ther
, vol.13
, pp. 1222-1234
-
-
Santel, A.1
Aleku, M.2
Keil, O.3
Endruschat, J.4
Esche, V.5
Fisch, G.6
Dames, S.7
Loffler, K.8
Fechtner, M.9
Arnold, W.10
Giese, K.11
Klippel, A.12
Kaufmann, J.13
-
31
-
-
84861459374
-
The interaction of PKN3 with RhoC promotes malignant growth
-
10.1016/j.molonc.2011.12.001, 22217540
-
Unsal-Kacmaz K, Ragunathan S, Rosfjord E, Dann S, Upeslacis E, Grillo M, Hernandez R, Mack F, Klippel A. The interaction of PKN3 with RhoC promotes malignant growth. Mol Oncol 2012, 6:284-298. 10.1016/j.molonc.2011.12.001, 22217540.
-
(2012)
Mol Oncol
, vol.6
, pp. 284-298
-
-
Unsal-Kacmaz, K.1
Ragunathan, S.2
Rosfjord, E.3
Dann, S.4
Upeslacis, E.5
Grillo, M.6
Hernandez, R.7
Mack, F.8
Klippel, A.9
-
32
-
-
84877681517
-
ClinicalTrials.gov: Study With Atu027 in Patients With Advanced Solid Cancer
-
ClinicalTrials.gov: Study With Atu027 in Patients With Advanced Solid Cancer. , http://www.clinicaltrials.gov/ct2/show/NCT00938574?term=atu027&rank = 1
-
-
-
-
33
-
-
23044506285
-
Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery
-
10.1158/0008-5472.CAN-05-0530, 16061675
-
Landen CN, Chavez-Reyes A, Bucana C, Schmandt R, Deavers MT, Lopez-Berestein G, Sood AK. Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. Cancer Res 2005, 65:6910-6918. 10.1158/0008-5472.CAN-05-0530, 16061675.
-
(2005)
Cancer Res
, vol.65
, pp. 6910-6918
-
-
Landen, C.N.1
Chavez-Reyes, A.2
Bucana, C.3
Schmandt, R.4
Deavers, M.T.5
Lopez-Berestein, G.6
Sood, A.K.7
-
34
-
-
68049144915
-
Dual targeting of EphA2 and FAK in ovarian carcinoma
-
10.4161/cbt.8.11.8523, 2748749, 19395869
-
Shahzad MM, Lu C, Lee JW, Stone RL, Mitra R, Mangala LS, Lu Y, Baggerly KA, Danes CG, Nick AM, Halder J, Kim HS, Vivas-Mejia P, Landen CN, Lopez-Berestein G, Coleman RL, Sood AK. Dual targeting of EphA2 and FAK in ovarian carcinoma. Cancer Biol Ther 2009, 8:1027-1034. 10.4161/cbt.8.11.8523, 2748749, 19395869.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 1027-1034
-
-
Shahzad, M.M.1
Lu, C.2
Lee, J.W.3
Stone, R.L.4
Mitra, R.5
Mangala, L.S.6
Lu, Y.7
Baggerly, K.A.8
Danes, C.G.9
Nick, A.M.10
Halder, J.11
Kim, H.S.12
Vivas-Mejia, P.13
Landen, C.N.14
Lopez-Berestein, G.15
Coleman, R.L.16
Sood, A.K.17
-
35
-
-
84877652267
-
ClinicalTrials.gov: EphA2 Gene Targeting Using Neutral Liposomal Small Interfering RNA Delivery
-
ClinicalTrials.gov: EphA2 Gene Targeting Using Neutral Liposomal Small Interfering RNA Delivery. , http://www.clinicaltrials.gov/ct2/show/NCT01591356?term=EphA2&rank = 1
-
-
-
-
36
-
-
77951132901
-
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
-
10.1038/nature08956, 2855406, 20305636
-
Davis ME, Zuckerman JE, Choi CH, Seligson D, Tolcher A, Alabi CA, Yen Y, Heidel JD, Ribas A. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 2010, 464:1067-1070. 10.1038/nature08956, 2855406, 20305636.
-
(2010)
Nature
, vol.464
, pp. 1067-1070
-
-
Davis, M.E.1
Zuckerman, J.E.2
Choi, C.H.3
Seligson, D.4
Tolcher, A.5
Alabi, C.A.6
Yen, Y.7
Heidel, J.D.8
Ribas, A.9
-
37
-
-
0345357073
-
Transferrin-containing, cyclodextrin polymer-based particles for tumor-targeted gene delivery
-
10.1021/bc034125f, 14624625
-
Bellocq NC, Pun SH, Jensen GS, Davis ME. Transferrin-containing, cyclodextrin polymer-based particles for tumor-targeted gene delivery. Bioconjug Chem 2003, 14:1122-1132. 10.1021/bc034125f, 14624625.
-
(2003)
Bioconjug Chem
, vol.14
, pp. 1122-1132
-
-
Bellocq, N.C.1
Pun, S.H.2
Jensen, G.S.3
Davis, M.E.4
-
38
-
-
84877092185
-
Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery
-
10.1158/1078-0432.CCR-12-2764, 23386691
-
Shen H, Rodriguez-Aguayo C, Xu R, Gonzalez-Villasana V, Mai J, Huang Y, Zhang G, Guo X, Bai L, Qin G, Deng X, Li Q, Erm DR, Aslan B, Liu X, Sakamoto J, Chavez-Reyes A, Han HD, Sood AK, Ferrari M, Lopez-Berestein G. Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery. Clin Cancer Res 2013, 19:1806-1815. 10.1158/1078-0432.CCR-12-2764, 23386691.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1806-1815
-
-
Shen, H.1
Rodriguez-Aguayo, C.2
Xu, R.3
Gonzalez-Villasana, V.4
Mai, J.5
Huang, Y.6
Zhang, G.7
Guo, X.8
Bai, L.9
Qin, G.10
Deng, X.11
Li, Q.12
Erm, D.R.13
Aslan, B.14
Liu, X.15
Sakamoto, J.16
Chavez-Reyes, A.17
Han, H.D.18
Sood, A.K.19
Ferrari, M.20
Lopez-Berestein, G.21
more..
-
39
-
-
77951699994
-
Sustained small interfering RNA delivery by mesoporous silicon particles
-
10.1158/0008-5472.CAN-09-3931, 3202607, 20430760
-
Tanaka T, Mangala LS, Vivas-Mejia PE, Nieves-Alicea R, Mann AP, Mora E, Han HD, Shahzad MM, Liu X, Bhavane R, Gu J, Fakhoury JR, Chiappini C, Lu C, Matsuo K, Godin B, Stone RL, Nick AM, Lopez-Berestein G, Sood AK, Ferrari M. Sustained small interfering RNA delivery by mesoporous silicon particles. Cancer Res 2010, 70:3687-3696. 10.1158/0008-5472.CAN-09-3931, 3202607, 20430760.
-
(2010)
Cancer Res
, vol.70
, pp. 3687-3696
-
-
Tanaka, T.1
Mangala, L.S.2
Vivas-Mejia, P.E.3
Nieves-Alicea, R.4
Mann, A.P.5
Mora, E.6
Han, H.D.7
Shahzad, M.M.8
Liu, X.9
Bhavane, R.10
Gu, J.11
Fakhoury, J.R.12
Chiappini, C.13
Lu, C.14
Matsuo, K.15
Godin, B.16
Stone, R.L.17
Nick, A.M.18
Lopez-Berestein, G.19
Sood, A.K.20
Ferrari, M.21
more..
-
40
-
-
84857914530
-
Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution
-
3422657, 22062689
-
van de Ven AL, Kim P, Haley O, Fakhoury JR, Adriani G, Schmulen J, Moloney P, Hussain F, Ferrari M, Liu X, Yun SH, Decuzzi P. Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution. J Control Release 2011, 158:148-155. 3422657, 22062689.
-
(2011)
J Control Release
, vol.158
, pp. 148-155
-
-
van de Ven, A.L.1
Kim, P.2
Haley, O.3
Fakhoury, J.R.4
Adriani, G.5
Schmulen, J.6
Moloney, P.7
Hussain, F.8
Ferrari, M.9
Liu, X.10
Yun, S.H.11
Decuzzi, P.12
-
41
-
-
80054756400
-
Multistage nanovectors: from concept to novel imaging contrast agents and therapeutics
-
10.1021/ar200077p, 3204797, 21902173
-
Godin B, Tasciotti E, Liu X, Serda RE, Ferrari M. Multistage nanovectors: from concept to novel imaging contrast agents and therapeutics. Acc Chem Res 2011, 44:979-989. 10.1021/ar200077p, 3204797, 21902173.
-
(2011)
Acc Chem Res
, vol.44
, pp. 979-989
-
-
Godin, B.1
Tasciotti, E.2
Liu, X.3
Serda, R.E.4
Ferrari, M.5
-
42
-
-
84877658682
-
Multistage vectored siRNA targeting ataxiatelangiectasia mutated for breast cancer therapy
-
Xu R, Huang Y, Mai J, Zhang G, Guo X, Xia X, Koay EJ, Qin G, Erm DR, Li Q, Liu X, Ferrari M, Shen H. Multistage vectored siRNA targeting ataxiatelangiectasia mutated for breast cancer therapy. Small 2013,
-
(2013)
Small
-
-
Xu, R.1
Huang, Y.2
Mai, J.3
Zhang, G.4
Guo, X.5
Xia, X.6
Koay, E.J.7
Qin, G.8
Erm, D.R.9
Li, Q.10
Liu, X.11
Ferrari, M.12
Shen, H.13
-
43
-
-
77956248928
-
Vectoring siRNA therapeutics into the clinic
-
10.1038/nrclinonc.2010.131, 20798696
-
Ferrari M. Vectoring siRNA therapeutics into the clinic. Nat Rev Clin Oncol 2010, 7:485-486. 10.1038/nrclinonc.2010.131, 20798696.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 485-486
-
-
Ferrari, M.1
-
44
-
-
67650479404
-
Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug
-
10.1038/nbt.1547, 19561595
-
MacDiarmid JA, Amaro-Mugridge NB, Madrid-Weiss J, Sedliarou I, Wetzel S, Kochar K, Brahmbhatt VN, Phillips L, Pattison ST, Petti C, Stillman B, Graham RM, Brahmbhatt H. Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug. Nat Biotechnol 2009, 27:643-651. 10.1038/nbt.1547, 19561595.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 643-651
-
-
MacDiarmid, J.A.1
Amaro-Mugridge, N.B.2
Madrid-Weiss, J.3
Sedliarou, I.4
Wetzel, S.5
Kochar, K.6
Brahmbhatt, V.N.7
Phillips, L.8
Pattison, S.T.9
Petti, C.10
Stillman, B.11
Graham, R.M.12
Brahmbhatt, H.13
-
45
-
-
44049100934
-
Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
-
10.1093/jnci/djn123, 18445819
-
Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, Wu MF, Hilsenbeck SG, Pavlick A, Zhang X, Chamness GC, Wong H, Rosen J, Chang JC. Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst 2008, 100:672-679. 10.1093/jnci/djn123, 18445819.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 672-679
-
-
Li, X.1
Lewis, M.T.2
Huang, J.3
Gutierrez, C.4
Osborne, C.K.5
Wu, M.F.6
Hilsenbeck, S.G.7
Pavlick, A.8
Zhang, X.9
Chamness, G.C.10
Wong, H.11
Rosen, J.12
Chang, J.C.13
-
46
-
-
84864673390
-
Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model
-
10.1371/journal.pone.0030207, 3412855, 22879872
-
Dave B, Landis MD, Dobrolecki LE, Wu MF, Zhang X, Westbrook TF, Hilsenbeck SG, Liu D, Lewis MT, Tweardy DJ, Chang JC. Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. PLoS One 2012, 7:e30207. 10.1371/journal.pone.0030207, 3412855, 22879872.
-
(2012)
PLoS One
, vol.7
-
-
Dave, B.1
Landis, M.D.2
Dobrolecki, L.E.3
Wu, M.F.4
Zhang, X.5
Westbrook, T.F.6
Hilsenbeck, S.G.7
Liu, D.8
Lewis, M.T.9
Tweardy, D.J.10
Chang, J.C.11
-
47
-
-
35449003175
-
MicroRNA let-7a down-regulates MYC and reverts MYCinduced growth in Burkitt lymphoma cells
-
10.1158/0008-5472.CAN-07-2462, 17942906
-
Sampson VB, Rong NH, Han J, Yang Q, Aris V, Soteropoulos P, Petrelli NJ, Dunn SP, Krueger LJ. MicroRNA let-7a down-regulates MYC and reverts MYCinduced growth in Burkitt lymphoma cells. Cancer Res 2007, 67:9762-9770. 10.1158/0008-5472.CAN-07-2462, 17942906.
-
(2007)
Cancer Res
, vol.67
, pp. 9762-9770
-
-
Sampson, V.B.1
Rong, N.H.2
Han, J.3
Yang, Q.4
Aris, V.5
Soteropoulos, P.6
Petrelli, N.J.7
Dunn, S.P.8
Krueger, L.J.9
-
48
-
-
77952360640
-
MicroRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling
-
10.1073/pnas.1002080107, 2889540, 20406904
-
Yu Z, Willmarth NE, Zhou J, Katiyar S, Wang M, Liu Y, McCue PA, Quong AA, Lisanti MP, Pestell RG. microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc Natl Acad Sci USA 2010, 107:8231-8236. 10.1073/pnas.1002080107, 2889540, 20406904.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 8231-8236
-
-
Yu, Z.1
Willmarth, N.E.2
Zhou, J.3
Katiyar, S.4
Wang, M.5
Liu, Y.6
McCue, P.A.7
Quong, A.A.8
Lisanti, M.P.9
Pestell, R.G.10
-
49
-
-
43049103824
-
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
-
10.1038/ncb1722, 18376396
-
Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, Vadas MA, Khew-Goodall Y, Goodall GJ. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008, 10:593-601. 10.1038/ncb1722, 18376396.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 593-601
-
-
Gregory, P.A.1
Bert, A.G.2
Paterson, E.L.3
Barry, S.C.4
Tsykin, A.5
Farshid, G.6
Vadas, M.A.7
Khew-Goodall, Y.8
Goodall, G.J.9
-
50
-
-
34250843675
-
The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines
-
10.1210/me.2007-0022, 17312270
-
Adams BD, Furneaux H, White BA. The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol 2007, 21:1132-1147. 10.1210/me.2007-0022, 17312270.
-
(2007)
Mol Endocrinol
, vol.21
, pp. 1132-1147
-
-
Adams, B.D.1
Furneaux, H.2
White, B.A.3
-
51
-
-
77952921840
-
MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer
-
10.1093/jnci/djq102, 2873185, 20388878
-
Di Leva G, Gasparini P, Piovan C, Ngankeu A, Garofalo M, Taccioli C, Iorio MV, Li M, Volinia S, Alder H, Nakamura T, Nuovo G, Liu Y, Nephew KP, Croce CM. MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer. J Natl Cancer Inst 2010, 102:706-721. 10.1093/jnci/djq102, 2873185, 20388878.
-
(2010)
J Natl Cancer Inst
, vol.102
, pp. 706-721
-
-
Di Leva, G.1
Gasparini, P.2
Piovan, C.3
Ngankeu, A.4
Garofalo, M.5
Taccioli, C.6
Iorio, M.V.7
Li, M.8
Volinia, S.9
Alder, H.10
Nakamura, T.11
Nuovo, G.12
Liu, Y.13
Nephew, K.P.14
Croce, C.M.15
-
52
-
-
84872376809
-
Suppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migration
-
10.1016/j.ccr.2012.11.019, 23328481
-
Ryu S, McDonnell K, Choi H, Gao D, Hahn M, Joshi N, Park SM, Catena R, Do Y, Brazin J, Vahdat LT, Silver RB, Mittal V. Suppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migration. Cancer Cell 2013, 23:63-76. 10.1016/j.ccr.2012.11.019, 23328481.
-
(2013)
Cancer Cell
, vol.23
, pp. 63-76
-
-
Ryu, S.1
McDonnell, K.2
Choi, H.3
Gao, D.4
Hahn, M.5
Joshi, N.6
Park, S.M.7
Catena, R.8
Do, Y.9
Brazin, J.10
Vahdat, L.T.11
Silver, R.B.12
Mittal, V.13
|