Experimental therapies: Vectoring siRNA therapeutics into the clinic

Nature Reviews Clinical Oncology

Volumn 7, Issue 9, 2010, Pages 485-486

  Ferrari, Mauro ^a  

^a HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLODEXTRIN; DOUBLE STRANDED RNA; EPHRIN RECEPTOR A2; LIPOSOME; MACROGOL; NANOPARTICLE; RIBONUCLEOTIDE REDUCTASE; SMALL INTERFERING RNA; TAXANE DERIVATIVE; TRANSFERRIN; TRANSFERRIN RECEPTOR;

BREAST CANCER; CELL PROLIFERATION; CLINICAL TRIAL; DOWN REGULATION; DRUG DELIVERY SYSTEM; ENZYME DEGRADATION; GENE OVEREXPRESSION; HUMAN; HYDROPHILICITY; MELANOMA; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RETICULOENDOTHELIAL SYSTEM; RNA INTERFERENCE; SHORT SURVEY; TUMOR LOCALIZATION; GENE VECTOR; GENETICS; NEOPLASM; NOTE;

GENETIC VECTORS; HUMANS; NANOPARTICLES; NEOPLASMS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 77956248928     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2010.131     Document Type: Short Survey

References (10)

1. Davis, M. E. et al. evidence of RnAi in humans from systemically administered siRnA via targeted nanoparticles. Nature 464, 1067-1070 (2010).
2. Bumcrot, D. et al. RnAi therapeutics: a potential new class of pharmaceutical drugs. Nat. Chem. Biol. 2, 711-719 (2006).
3. Castanotto, D. & Rossi, J. J. The promises and pitfalls of RnAi-interference-based therapeutics. Nature 457, 426-433 (2009).
4. Ferrari, M. Cancer nanotechnology: opportunities and challenges Nat. Rev. Cancer 5, 161-171 (2005).
5. Xia, H. et al. siRnA mediated gene silencing in vitro and in vivo. Nat. Biotechnol. 20, 1006-1010 (2002).
6. Landen, C. N. et al. Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RnA delivery. Cancer Res. 65, 6910-6918 (2005).
7. Halder, J. et al. Focal adhesion kinase targeting using in vivo short interfering RnA delivery in neutral liposomes for ovarian carcinoma therapy. Clin. Cancer Res. 12, 4916-4924 (2006).
8. woodrow, K. A. et al. intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RnA. Nat. Mater. 8, 526-533 (2009).
9. Ferrari, M. Frontiers in cancer nanomedicine: directing mass transport through biological barriers. Trends Biotechnol. 28, 181-188 (2010).
10. Tanaka, T. et al. sustained small interfering RnA delivery by mesoporous silicon particles. Cancer Res. 70, 3687-3696 (2010).