A phase II study of temozolomide in patients with advanced aerodigestive tract and colorectal cancers and methylation of the O6-methylguanine- DNA methyltransferase promoter

Molecular Cancer Therapeutics

Volumn 12, Issue 5, 2013, Pages 809-818

  Hochhauser, Daniel ^a   Glynne Jones, Rob ^b   Potter, Vanessa ^c   Grávalos, Cristina ^d   Doyle, Thomas J ^e   Pathiraja, Kumudu ^f   Zhang, Qing ^f   Zhang, Ling ^f   Sausville, Edward A ^g  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MOUNT VERNON HOSPITAL   (United Kingdom)

^c NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^d HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^e HENRY FORD HEALTH SYSTEM   (United States)

^f MERCK RESEARCH LABORATORIES   (United States)

^g UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TEMOZOLOMIDE;

ADULT; ADVANCED CANCER; AGED; ANEMIA; ANOREXIA; ARTICLE; ASTHENIA; BLOOD SAMPLING; CANCER PATIENT; CANCER SURVIVAL; COLORECTAL CANCER; CONSTIPATION; DIARRHEA; DIGESTIVE SYSTEM CANCER; DIZZINESS; DNA METHYLATION; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ESOPHAGUS CANCER; FATIGUE; FEMALE; HEAD AND NECK CANCER; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MULTIPLE CYCLE TREATMENT; NAUSEA; OVERALL SURVIVAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROMOTER REGION; RASH; SIDE EFFECT; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TREATMENT RESPONSE; VOMITING;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, ALKYLATING; COLORECTAL NEOPLASMS; DACARBAZINE; DNA METHYLATION; DNA MISMATCH REPAIR; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROMOTER REGIONS, GENETIC; TREATMENT OUTCOME;

EID: 84877646733     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-12-0710     Document Type: Article

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