Silencing of the Charcot-Marie-Tooth disease-associated gene GDAP1 induces abnormal mitochondrial distribution and affects Ca2+ homeostasis by reducing store-operated Ca2+ entry

Neurobiology of Disease

Volumn 55, Issue , 2013, Pages 140-151

  Pla Martín, David ^a,b,c,d   Rueda, Carlos B ^b,c,e   Estela, Anna ^a,b,c,d   Sánchez Piris, Maribel ^a   González Sánchez, Paloma ^d,e   Traba, Javier ^b,c,e   de la Fuente, Sergio ^f   Scorrano, Luca ^g,h   Renau Piqueras, Jaime ⁱ   Alvarez, Javier ^f   Satrústegui, Jorgina ^b,c,e   Palau, Francesc ^a,b,c,d,j  

^a INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^c Centro de Investigación Príncipe Felipe ^*

^d CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^e CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^f UNIVERSITY OF VALLADOLID   (Spain)

^g VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^h UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

ⁱ INSTITUTO DE INVESTIGACIÓN SANITARIA DEL HOSPITAL CLÍNICO SAN CARLOS IDISSC   (Spain)

^j UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

more..

Author keywords

Calcium homeostasis; Charcot Marie Tooth disease; Endoplasmic reticulum; GDAP1; Mitochondrial distribution and motility; Store operated Ca2+ entry

Indexed keywords

CALCIUM ION; CARRIER PROTEIN; CAYTAXIN; GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 1; MEMBRANE PROTEIN; RAB6B PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL LINE; CELL MEMBRANE; CONTROLLED STUDY; CYTOSKELETON; ENDOPLASMIC RETICULUM; GDAP1 GENE; GENE MUTATION; GENE SILENCING; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; HUMAN CELL; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN INTERACTION;

ADENOSINE TRIPHOSPHATE; CALCIUM; CALCIUM SIGNALING; CELL LINE, TRANSFORMED; CHELATING AGENTS; COATOMER PROTEIN; CYTOSKELETON; EGTAZIC ACID; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HOMEOSTASIS; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUTATION, MISSENSE; NERVE TISSUE PROTEINS; PROTEIN TRANSPORT; RAB GTP-BINDING PROTEINS; RECEPTORS, CELL SURFACE; RNA INTERFERENCE; TRANSFECTION;

EID: 84877633295     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.03.010     Document Type: Article

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