Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains

Journal of Cell Science

Volumn 122, Issue 22, 2009, Pages 4177-4185

  Aoyama, Takane ^a   Hata, Suguru ^a   Nakao, Takeshi ^a   Tanigawa, Yuka ^a   Oka, Chio ^a   Kawaichi, Masashi ^a  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

Atcay; Axonal trafficking; BNIP 2; Cayman ataxia; Kinesin; Kinesin light chain

Indexed keywords

BINDING PROTEIN; CALSYNTENIN; CAYTAXIN; KINESIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DENDRITE; HIPPOCAMPUS; LIGHT CHAIN; MICROTUBULE; MITOCHONDRION; NERVE FIBER; NEURITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; RNA INTERFERENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ATAXIA; AXONAL TRANSPORT; BINDING SITES; CELL LINE; HIPPOCAMPUS; HUMANS; KINESIN; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MITOCHONDRIA; NERVE TISSUE PROTEINS; NEURONS; PROTEIN SUBUNITS; RATS; RECEPTORS, CELL SURFACE; RNA INTERFERENCE; TWO-HYBRID SYSTEM TECHNIQUES;

MUS; RATTUS;

EID: 70849109384     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.048579     Document Type: Article

References (33)

1. Arsid, Y., Kawano, T., Tara, H., Saito, Y., Wada, S, Miyamoto, K, Kobayashi, H., Ishikawa, H. O., Ohsugi, Y., Yamamoto, T. et al. (2007). The novel cargo alcadein induces vesicle association of kinesin-1 motorcomporients and activates axonal tramport. EMBO J. 26, 1475-1486.
2. Boeckers, T. M., Bockmarm, J., Krcutz, M. R. and Gundellinger, E. D. (2002). ProSAP/Shank proteins-a family of lugher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease. J Neurochem. 81, 903-910.
3. Bomar, J. M., Benke, P. J., Slattery, E. L., Puttagunta, R., Taylor, L. P., Seong, E., Nystuen, A., Chen, W., Albin, R. L., Patel, P. D. et al. (2003). Mutations in a novel gene encoding a CRAL-TRIO domain cause human cayman ataxia and ataxia/dystonia in the jittery mouse. Nat. Genet. 35, 264-269.
4. Boyd, J. M., Malstrom, S., Subramanian, T., Venkatesh, L. K., Schaeper, U., Elangovan, B., D'Sa-Eipper, C. and Chinnadurai, G. (1994). Adenovirus E1B 19 kDa and bcl-2 proteins interact with a common set of cellular proteins. Cell 79, 341-351.
5. Brown, L., Mueller, M. and Benke, P. J. (1984). A non-progressive cerebellar ataxia on Grand Cayman Island. Neurology 34, 271-273.
6. Buschdorf, J. P., Li, Chew, L., Zhang, B., Cao, Q., Liang, F. Y., Liou, Y. C., Zhou, Y. T. and Low, B. C. (2006). Brain-specific BNIP-2-homology protein caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels. J. Cell Sci. 119, 3337-3350.
7. Buschdorf, J. P., Chew, L. L., Soh, U. J., Liou, Y. C. and Low, B. C. (2008). Nerve growth factor stimulates interaction of cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons. PLoS ONE 3, e2686.
8. Chen, C. and Okayama, H. (1987). High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell Biol. 7, 2745-2752.
9. Curthoys, N. P. and Watford, M. (1995). Regulation of glutaminase activity and glutamine metabolism. Annu. Rev. Nutr. 15, 133-159.
10. Gilbert, N., Bomar, J. M., Burmeister, M. and Moran, J. V. (2004). Characterization of a mutagenic B1 retrotransposon insertion in the jittery mouse. Hum. Mutat. 24, 9-13.
11. Grelle, G., Kostka, S., Otto, A., Kersten, B., Genser, K. F., Muller, E. C., Walter, S., Boddrich, A., Stelzl, U., Hanig, C. et al. (2006). Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. Mol. Cell Proteomics 5, 234-244.
12. Hayakawa, Y., Itoh, M., Yamada, A., Mitsuda, T. and Nakagawa, T. (2007). Expression and localization of cayman ataxia-related protein, caytaxin, is regulated in a developmental- and spatial-dependent manner. Brain Res. 1129, 100-109.
13. Hirokawa, N. and Takemura, R. (2005). Molecular motors and mechanisms of directional transport in neurons. Nat. Rev. Neurosci. 6, 201-214.
14. Hosoda, A., Kimata, Y., Tsuru, A. and Kohno, K. (2003). JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs. J. Biol. Chem. 278, 2669-2676.
15. Inagaki, N., Chihara, K., Arimura, N., Menager, C., Kawano, Y., Matsuo, N., Nishimura, T., Amano, M. and Kaibuchi, K. (2001). CRMP-2 induces axons in cultured hippocampal neurons. Nat. Neurosci. 4, 781-782.
16. Jonson, W. G., Murphy, M., Murphy, W. I. and Bloom, A. D. (1978). Recessive congenital cerebellar disorder in a genetic isolate:CPD TypeVII? Neurology 28, 351-352.
17. Kapfhamer, D., Sweet, H. O., Sufalko, D., Warren, S., Johnson, K. R. and Burmeister, M. (1996). The neurological mouse mutations jittery and hesitant are allelic and map to the region of mouse chromosome 10 homologous to 19p13.3. Genomics 35, 533-538.
18. Kimura, T., Watanabe, H., Iwamatsu, A. and Kaibuchi, K. (2005). Tubulin and CRMP-2 complex is transported via kinesin-1. J. Neurochem. 93, 1371-1382.
19. Konecna, A., Frischknecht, R., Kinter, J., Ludwig, A., Steuble, M., Meskenaite, V., Indermuhle, M., Engel, M., Cen, C., Mateos, J. M. et al. (2006). Calsyntenin-1 docks vesicular cargo to kinesin-1. Mol. Biol. Cell 17, 3651-3663.
20. LeDoux, M. S., Lorden, J. F. and Ervin, J. M. (1993). Cerebellectomy eliminates the motor syndrome of the genetically dystonic rat. Exp. Neurol. 120, 302-310.
21. Morfini, G., Tsai, M. Y., Szebenyi, G. and Brady, S. T. (2001). Approaches to study interactions between kinesin motors and membranes. Methods Mol. Biol. 164, 147-162.
22. Nystuen, A., Benke, P. J., Merren, J., Stone, E. M. and Sheffield, V. C. (1996). A cerebellar ataxia locus identified by DNA pooling to search for linkage disequilibrium in an isolated population from the cayman islands. Hum. Mol. Genet. 5, 525-531.
23. Panagabko, C., Morley, S., Hernandez, M., Cassolato, P., Gordon, H., Parsons, R., Manor, D. and Atkinson, J. (2003). Ligand specificity in the CRAL-TRIO protein family. Biochemistry 42, 6467-6474.
24. Qin, W., Hu, J., Guo, M., Xu, J., Li, J., Yao, G., Zhou, X., Jiang, H., Zhang, P., Shen, L. et al. (2003). BNIPL-2, a novel homologue of BNIP-2, interacts with bcl-2 and Cdc42GAP in apoptosis. Biochem. Biophys. Res. Commun. 308, 379-385.
25. Salinas, S., Bilsland, L. G. and Schiavo, G. (2008). Molecular landmarks along the axonal route: Axonal transport in health and disease. Curr. Opin. Cell Biol. 20, 445-453.
26. van der Voorn, L. and Ploegh, H. L. (1992). The WD-40 repeat. FEBS Lett. 307, 131-134.
27. Ward, B. M. and Moss, B. (2004). Vaccinia virus A36R membrane protein provides a direct link between intracellular enveloped virions and the microtubule motor kinesin. J. Virol. 78, 2486-2493.
28. Whitmarsh, A. J. and Davis, R. J. (1998). Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals. Trends Biochem. Sci. 23, 481-485.
29. Xiao, J. and Ledoux, M. S. (2005). Caytaxin deficiency causes generalized dystonia in rats. Brain Res. Mol. Brain Res. 141, 181-192.
30. Xiao, J., Gong, S. and Ledoux, M. S. (2007). Caytaxin deficiency disrupts signaling pathways in cerebellar cortex. Neuroscience 144, 439-461.
31. Zhou, Y. T., Soh, U. J., Shang, X., Guy, G. R. and Low, B. C. (2002). The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-salpha is a novel apoptosis-inducing sequence. J. Biol. Chem. 277, 7483-7492.
32. Zhou, Y. T., Guy, G. R. and Low, B. C. (2005). BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain. Exp. Cell Res. 303, 263-274.
33. Zhou, Y. T., Guy, G. R. and Low, B. C. (2006). BNIP-salpha induces cell rounding and apoptosis by displacing p50RhoGAP and facilitating RhoA activation via its unique motifs in the BNIP-2 and Cdc42GAP homology domain. Oncogene 25, 2393-2408.