-
1
-
-
2342430345
-
LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way
-
He X, Semenov M, Tamai K, Zeng X, (2004) LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. Development 131: 1663-1677.
-
(2004)
Development
, vol.131
, pp. 1663-1677
-
-
He, X.1
Semenov, M.2
Tamai, K.3
Zeng, X.4
-
2
-
-
4344584730
-
WNT and beta-catenin signalling: diseases and therapies
-
Moon RT, Kohn AD, De Ferrari GV, Kaykas A, (2004) WNT and beta-catenin signalling: diseases and therapies. Nat Rev Genet 5: 691-701.
-
(2004)
Nat Rev Genet
, vol.5
, pp. 691-701
-
-
Moon, R.T.1
Kohn, A.D.2
De Ferrari, G.V.3
Kaykas, A.4
-
3
-
-
0032581370
-
Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family
-
Brown SD, Twells RC, Hey PJ, Cox RD, Levy ER, et al. (1998) Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family. Biochem Biophys Res Commun 248: 879-888.
-
(1998)
Biochem Biophys Res Commun
, vol.248
, pp. 879-888
-
-
Brown, S.D.1
Twells, R.C.2
Hey, P.J.3
Cox, R.D.4
Levy, E.R.5
-
4
-
-
0033082267
-
Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human
-
Chen D, Lathrop W, Dong Y, (1999) Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human. Genomics 55: 314-321.
-
(1999)
Genomics
, vol.55
, pp. 314-321
-
-
Chen, D.1
Lathrop, W.2
Dong, Y.3
-
5
-
-
0032541395
-
Cloning of a novel member of the low-density lipoprotein receptor family
-
Hey PJ, Twells RC, Phillips MS, Yusuke N, Brown SD, et al. (1998) Cloning of a novel member of the low-density lipoprotein receptor family. Gene 216: 103-111.
-
(1998)
Gene
, vol.216
, pp. 103-111
-
-
Hey, P.J.1
Twells, R.C.2
Phillips, M.S.3
Yusuke, N.4
Brown, S.D.5
-
6
-
-
0037144481
-
A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling
-
Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO, (2002) A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta-catenin-dependent signaling. J Biol Chem 277: 34727-34735.
-
(2002)
J Biol Chem
, vol.277
, pp. 34727-34735
-
-
Holmen, S.L.1
Salic, A.2
Zylstra, C.R.3
Kirschner, M.W.4
Williams, B.O.5
-
7
-
-
2342441840
-
The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
-
Kelly OG, Pinson KI, Skarnes WC, (2004) The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development 131: 2803-2815.
-
(2004)
Development
, vol.131
, pp. 2803-2815
-
-
Kelly, O.G.1
Pinson, K.I.2
Skarnes, W.C.3
-
8
-
-
0034727104
-
LDL-receptor-related proteins in Wnt signal transduction
-
Tamai K, Semenov M, Kato Y, Spokony R, Liu C, et al. (2000) LDL-receptor-related proteins in Wnt signal transduction. Nature 407: 530-535.
-
(2000)
Nature
, vol.407
, pp. 530-535
-
-
Tamai, K.1
Semenov, M.2
Kato, Y.3
Spokony, R.4
Liu, C.5
-
9
-
-
0034727078
-
An LDL-receptor-related protein mediates Wnt signalling in mice
-
Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC, (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 407: 535-538.
-
(2000)
Nature
, vol.407
, pp. 535-538
-
-
Pinson, K.I.1
Brennan, J.2
Monkley, S.3
Avery, B.J.4
Skarnes, W.C.5
-
10
-
-
0033798233
-
Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes
-
Figueroa DJ, Hess JF, Ky B, Brown SD, Sandig V, et al. (2000) Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes. J Histochem Cytochem 48: 1357-1368.
-
(2000)
J Histochem Cytochem
, vol.48
, pp. 1357-1368
-
-
Figueroa, D.J.1
Hess, J.F.2
Ky, B.3
Brown, S.D.4
Sandig, V.5
-
11
-
-
0032446373
-
A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E. Journal of biochemistry
-
Kim DH, Inagaki Y, Suzuki T, Ioka RX, Yoshioka SZ, et al. (1998) A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E. Journal of biochemistry. 124: 1072-1076.
-
(1998)
, vol.124
, pp. 1072-1076
-
-
Kim, D.H.1
Inagaki, Y.2
Suzuki, T.3
Ioka, R.X.4
Yoshioka, S.Z.5
-
12
-
-
55749091843
-
Parathyroid hormone signaling through low-density lipoprotein-related protein 6
-
Wan M, Yang C, Li J, Wu X, Yuan H, et al. (2008) Parathyroid hormone signaling through low-density lipoprotein-related protein 6. Genes & development 22: 2968-2979.
-
(2008)
Genes & Development
, vol.22
, pp. 2968-2979
-
-
Wan, M.1
Yang, C.2
Li, J.3
Wu, X.4
Yuan, H.5
-
13
-
-
18044386744
-
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
-
Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, et al. (2001) LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107: 513-523.
-
(2001)
Cell
, vol.107
, pp. 513-523
-
-
Gong, Y.1
Slee, R.B.2
Fukai, N.3
Rawadi, G.4
Roman-Roman, S.5
-
14
-
-
0037092049
-
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
-
Kato M, Patel MS, Levasseur R, Lobov I, Chang BH, et al. (2002) Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol 157: 303-314.
-
(2002)
J Cell Biol
, vol.157
, pp. 303-314
-
-
Kato, M.1
Patel, M.S.2
Levasseur, R.3
Lobov, I.4
Chang, B.H.5
-
15
-
-
0037118285
-
High bone density due to a mutation in LDL-receptor-related protein 5
-
Boyden LM, Mao J, Belsky J, Mitzner L, Farhi A, et al. (2002) High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 346: 1513-1521.
-
(2002)
N Engl J Med
, vol.346
, pp. 1513-1521
-
-
Boyden, L.M.1
Mao, J.2
Belsky, J.3
Mitzner, L.4
Farhi, A.5
-
16
-
-
0036138175
-
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
-
Little RD, Carulli JP, Del Mastro RG, Dupuis J, Osborne M, et al. (2002) A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet 70: 11-19.
-
(2002)
Am J Hum Genet
, vol.70
, pp. 11-19
-
-
Little, R.D.1
Carulli, J.P.2
Del Mastro, R.G.3
Dupuis, J.4
Osborne, M.5
-
17
-
-
33847656105
-
LRP6 mutation in a family with early coronary disease and metabolic risk factors
-
Mani A, Radhakrishnan J, Wang H, Mani MA, Nelson-Williams C, et al. (2007) LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science 315: 1278-1282.
-
(2007)
Science
, vol.315
, pp. 1278-1282
-
-
Mani, A.1
Radhakrishnan, J.2
Wang, H.3
Mani, M.A.4
Nelson-Williams, C.5
-
18
-
-
20444376156
-
Essential role of beta-catenin in postnatal bone acquisition
-
Holmen SL, Zylstra CR, Mukherjee A, Sigler RE, Faugere MC, et al. (2005) Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem 280: 21162-21168.
-
(2005)
J Biol Chem
, vol.280
, pp. 21162-21168
-
-
Holmen, S.L.1
Zylstra, C.R.2
Mukherjee, A.3
Sigler, R.E.4
Faugere, M.C.5
-
19
-
-
20244373613
-
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
-
Glass DA, 2nd, Bialek P, Ahn JD, Starbuck M, Patel MS, et al (2005) Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 8: 751-764.
-
(2005)
Dev Cell
, vol.8
, pp. 751-764
-
-
Glass II, D.A.1
Bialek, P.2
Ahn, J.D.3
Starbuck, M.4
Patel, M.S.5
-
20
-
-
0037422571
-
Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion
-
Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, et al. (2003) Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci U S A 100: 229-234.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 229-234
-
-
Fujino, T.1
Asaba, H.2
Kang, M.J.3
Ikeda, Y.4
Sone, H.5
-
21
-
-
33747674263
-
The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment
-
Sawakami K, Robling AG, Ai M, Pitner ND, Liu D, et al. (2006) The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem 281: 23698-23711.
-
(2006)
J Biol Chem
, vol.281
, pp. 23698-23711
-
-
Sawakami, K.1
Robling, A.G.2
Ai, M.3
Pitner, N.D.4
Liu, D.5
-
22
-
-
13444295117
-
Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6
-
Holmen SL, Giambernardi TA, Zylstra CR, Buckner-Berghuis BD, Resau JH, et al. (2004) Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res 19: 2033-2040.
-
(2004)
J Bone Miner Res
, vol.19
, pp. 2033-2040
-
-
Holmen, S.L.1
Giambernardi, T.A.2
Zylstra, C.R.3
Buckner-Berghuis, B.D.4
Resau, J.H.5
-
23
-
-
77953364154
-
Genetic analysis of Lrp5 function in osteoblast progenitors
-
Yadav VK, Arantes HP, Barros ER, Lazaretti-Castro M, Ducy P, (2010) Genetic analysis of Lrp5 function in osteoblast progenitors. Calcif tissue int 86: 382-388.
-
(2010)
Calcif Tissue Int
, vol.86
, pp. 382-388
-
-
Yadav, V.K.1
Arantes, H.P.2
Barros, E.R.3
Lazaretti-Castro, M.4
Ducy, P.5
-
24
-
-
56349162283
-
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum
-
Yadav VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, et al. (2008) Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135: 825-837.
-
(2008)
Cell
, vol.135
, pp. 825-837
-
-
Yadav, V.K.1
Ryu, J.H.2
Suda, N.3
Tanaka, K.F.4
Gingrich, J.A.5
-
25
-
-
77953451716
-
Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin
-
Frost M, Andersen TE, Yadav V, Brixen K, Karsenty G, et al. (2010) Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin. J Bone Miner Res 25: 673-675.
-
(2010)
J Bone Miner Res
, vol.25
, pp. 673-675
-
-
Frost, M.1
Andersen, T.E.2
Yadav, V.3
Brixen, K.4
Karsenty, G.5
-
26
-
-
82455186482
-
Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo
-
Joeng KS, Schumacher CA, Zylstra-Diegel CR, Long F, Williams BO, (2011) Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo. Dev Biol 359: 222-229.
-
(2011)
Dev Biol
, vol.359
, pp. 222-229
-
-
Joeng, K.S.1
Schumacher, C.A.2
Zylstra-Diegel, C.R.3
Long, F.4
Williams, B.O.5
-
27
-
-
79958171733
-
Lrp5 functions in bone to regulate bone mass
-
Cui Y, Niziolek PJ, MacDonald BT, Zylstra CR, Alenina N, et al. (2011) Lrp5 functions in bone to regulate bone mass. Nat Med 17: 684-691.
-
(2011)
Nat Med
, vol.17
, pp. 684-691
-
-
Cui, Y.1
Niziolek, P.J.2
MacDonald, B.T.3
Zylstra, C.R.4
Alenina, N.5
-
28
-
-
9444235153
-
Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis
-
Kokubu C, Heinzmann U, Kokubu T, Sakai N, Kubota T, et al. (2004) Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis. Development 131: 5469-5480.
-
(2004)
Development
, vol.131
, pp. 5469-5480
-
-
Kokubu, C.1
Heinzmann, U.2
Kokubu, T.3
Sakai, N.4
Kubota, T.5
-
29
-
-
52949105706
-
Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd
-
Kubota T, Michigami T, Sakaguchi N, Kokubu C, Suzuki A, et al. (2008) Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd. J Bone Miner Res 23: 1661-1671.
-
(2008)
J Bone Miner Res
, vol.23
, pp. 1661-1671
-
-
Kubota, T.1
Michigami, T.2
Sakaguchi, N.3
Kokubu, C.4
Suzuki, A.5
-
30
-
-
84055218466
-
Lrp5 and Lrp6 play compensatory roles in mouse intestinal development
-
Zhong Z, Baker JJ, Zylstra-Diegel CR, Williams BO, (2012) Lrp5 and Lrp6 play compensatory roles in mouse intestinal development. J Cell Biochem 113: 31-38.
-
(2012)
J Cell Biochem
, vol.113
, pp. 31-38
-
-
Zhong, Z.1
Baker, J.J.2
Zylstra-Diegel, C.R.3
Williams, B.O.4
-
31
-
-
0347721834
-
Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization
-
Zhang M, Xuan S, Bouxsein ML, von Stechow D, Akeno N, et al. (2002) Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem 277: 44005-44012.
-
(2002)
J Biol Chem
, vol.277
, pp. 44005-44012
-
-
Zhang, M.1
Xuan, S.2
Bouxsein, M.L.3
von Stechow, D.4
Akeno, N.5
-
32
-
-
0035034603
-
Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development
-
Brault V, Moore R, Kutsch S, Ishibashi M, Rowitch DH, et al. (2001) Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128: 1253-1264.
-
(2001)
Development
, vol.128
, pp. 1253-1264
-
-
Brault, V.1
Moore, R.2
Kutsch, S.3
Ishibashi, M.4
Rowitch, D.H.5
-
33
-
-
77954756294
-
Guidelines for assessment of bone microstructure in rodents using micro-computed tomography
-
Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ, et al. (2010) Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res 25: 1468-1486.
-
(2010)
J Bone Miner Res
, vol.25
, pp. 1468-1486
-
-
Bouxsein, M.L.1
Boyd, S.K.2
Christiansen, B.A.3
Guldberg, R.E.4
Jepsen, K.J.5
-
34
-
-
0023488581
-
Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee
-
Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, et al. (1987) Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2: 595-610.
-
(1987)
J Bone Miner Res
, vol.2
, pp. 595-610
-
-
Parfitt, A.M.1
Drezner, M.K.2
Glorieux, F.H.3
Kanis, J.A.4
Malluche, H.5
-
35
-
-
33846026749
-
Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone
-
Robinson JA, Chatterjee-Kishore M, Yaworsky PJ, Cullen DM, Zhao W, et al. (2006) Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem 281: 31720-31728.
-
(2006)
J Biol Chem
, vol.281
, pp. 31720-31728
-
-
Robinson, J.A.1
Chatterjee-Kishore, M.2
Yaworsky, P.J.3
Cullen, D.M.4
Zhao, W.5
-
36
-
-
10744224854
-
High bone mass in mice expressing a mutant LRP5 gene
-
Babij P, Zhao W, Small C, Kharode Y, Yaworsky PJ, et al. (2003) High bone mass in mice expressing a mutant LRP5 gene. J Bone Miner Res 18: 960-974.
-
(2003)
J Bone Miner Res
, vol.18
, pp. 960-974
-
-
Babij, P.1
Zhao, W.2
Small, C.3
Kharode, Y.4
Yaworsky, P.J.5
-
37
-
-
17844363974
-
Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes
-
Hill TP, Spater D, Taketo MM, Birchmeier W, Hartmann C, (2005) Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 8: 727-738.
-
(2005)
Dev Cell
, vol.8
, pp. 727-738
-
-
Hill, T.P.1
Spater, D.2
Taketo, M.M.3
Birchmeier, W.4
Hartmann, C.5
|