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Volumn 15, Issue 6, 2013, Pages 538-545

Lack of GPR40/FFAR1 does not induce diabetes even under insulin resistance condition

Author keywords

Free fatty acids; Insulin secretion; Type 2 diabetes; cell

Indexed keywords

FATTY ACID; G PROTEIN COUPLED RECEPTOR 40; GLUCAGON; GLUCOSE; GLUCOSE TRANSPORTER 2; INSULIN; LEPTIN; PALMITIC ACID; PROINSULIN; G PROTEIN COUPLED RECEPTOR; GPR40 PROTEIN, MOUSE; GLUCOSE BLOOD LEVEL;

EID: 84877615793     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12065     Document Type: Article
Times cited : (19)

References (36)
  • 1
    • 0026733643 scopus 로고
    • Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion
    • Prentki M, Vischer S, Glennon MC, Regazzi R, Deeney JT, Corkey BE. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion. J Biol Chem 1992; 267: 5802-5810.
    • (1992) J Biol Chem , vol.267 , pp. 5802-5810
    • Prentki, M.1    Vischer, S.2    Glennon, M.C.3    Regazzi, R.4    Deeney, J.T.5    Corkey, B.E.6
  • 2
    • 0142093526 scopus 로고    scopus 로고
    • Fatty acid metabolism and insulin secretion in pancreatic β cells
    • Yaney GC, Corkey BE. Fatty acid metabolism and insulin secretion in pancreatic β cells. Diabetologia 2003; 46: 1297-1312.
    • (2003) Diabetologia , vol.46 , pp. 1297-1312
    • Yaney, G.C.1    Corkey, B.E.2
  • 3
    • 0037434991 scopus 로고    scopus 로고
    • Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
    • Itoh Y, Kawamata Y, Harada M et al. Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40. Nature 2003; 422: 173-176.
    • (2003) Nature , vol.422 , pp. 173-176
    • Itoh, Y.1    Kawamata, Y.2    Harada, M.3
  • 4
    • 0037838892 scopus 로고    scopus 로고
    • The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
    • Briscoe CP, Tadayyon M et al. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem 2003; 278: 11303-11311.
    • (2003) J Biol Chem , vol.278 , pp. 11303-11311
    • Briscoe, C.P.1    Tadayyon, M.2
  • 5
    • 0346041542 scopus 로고    scopus 로고
    • Progress in methodology. Improved reporter gene assays used to identify ligands acting on orphan seven-transmembrane receptors
    • Kotarsky K, Nilsson NE, Olde B, Owman C. Progress in methodology. Improved reporter gene assays used to identify ligands acting on orphan seven-transmembrane receptors. Pharmacol Toxicol 2003; 93: 249-258.
    • (2003) Pharmacol Toxicol , vol.93 , pp. 249-258
    • Kotarsky, K.1    Nilsson, N.E.2    Olde, B.3    Owman, C.4
  • 6
    • 25144470087 scopus 로고    scopus 로고
    • Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet β-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release
    • Fujiwara K, Maekawa F, Yada T. Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet β-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release. Am J Physiol Endocrinol Metab 2005; 289: E670-677.
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Fujiwara, K.1    Maekawa, F.2    Yada, T.3
  • 7
    • 27844449497 scopus 로고    scopus 로고
    • GPR40 gene expression in human pancreas and insulinoma
    • Tomita T, Masuzaki H, Noguchi M et al. GPR40 gene expression in human pancreas and insulinoma. Biochem Biophys Res Commun 2005; 338: 1788-1790.
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 1788-1790
    • Tomita, T.1    Masuzaki, H.2    Noguchi, M.3
  • 8
    • 33646395425 scopus 로고    scopus 로고
    • Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic β cells and implications for insulin secretion
    • Tomita T, Masuzaki H, Iwakura H et al. Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic β cells and implications for insulin secretion. Diabetologia 2006; 49: 962-968.
    • (2006) Diabetologia , vol.49 , pp. 962-968
    • Tomita, T.1    Masuzaki, H.2    Iwakura, H.3
  • 9
    • 11844275233 scopus 로고    scopus 로고
    • A family of fatty acid binding receptors
    • Brown AJ, Jupe S, Briscoe CP. A family of fatty acid binding receptors. DNA Cell Biol 2005; 24: 54-61.
    • (2005) DNA Cell Biol , vol.24 , pp. 54-61
    • Brown, A.J.1    Jupe, S.2    Briscoe, C.P.3
  • 11
    • 30944455097 scopus 로고    scopus 로고
    • The free fatty acid receptor GPR40 generates excitement in pancreatic β-cells
    • Gromada J. The free fatty acid receptor GPR40 generates excitement in pancreatic β-cells. Endocrinology 2006; 147: 672-673.
    • (2006) Endocrinology , vol.147 , pp. 672-673
    • Gromada, J.1
  • 12
    • 33751520308 scopus 로고    scopus 로고
    • Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from β-cells through activation of GPR40
    • Schnell S, Schaefer M, Schofl C. Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from β-cells through activation of GPR40. Mol Cell Endocrinol 2007; 263(1-2): 173-180.
    • (2007) Mol Cell Endocrinol , vol.263 , Issue.1-2 , pp. 173-180
    • Schnell, S.1    Schaefer, M.2    Schofl, C.3
  • 13
    • 50949128408 scopus 로고    scopus 로고
    • Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice
    • Tan CP, Feng Y, Zhou YP et al. Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. Diabetes 2008; 57: 2211-2219.
    • (2008) Diabetes , vol.57 , pp. 2211-2219
    • Tan, C.P.1    Feng, Y.2    Zhou, Y.P.3
  • 14
    • 33745607930 scopus 로고    scopus 로고
    • Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules
    • Briscoe CP, Peat AJ, McKeown SC et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol 2006; 148: 619-628.
    • (2006) Br J Pharmacol , vol.148 , pp. 619-628
    • Briscoe, C.P.1    Peat, A.J.2    McKeown, S.C.3
  • 15
    • 34250879091 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists
    • Song F, Lu S, Gunnet J et al. Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists. J Med Chem 2007; 50: 2807-2817.
    • (2007) J Med Chem , vol.50 , pp. 2807-2817
    • Song, F.1    Lu, S.2    Gunnet, J.3
  • 16
    • 65549114432 scopus 로고    scopus 로고
    • Overexpression of GPR40 in pancreatic β-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice
    • Nagasumi K, Esaki R, Iwachidow K et al. Overexpression of GPR40 in pancreatic β-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice. Diabetes 2009; 58: 1067-1076.
    • (2009) Diabetes , vol.58 , pp. 1067-1076
    • Nagasumi, K.1    Esaki, R.2    Iwachidow, K.3
  • 17
    • 80053138180 scopus 로고    scopus 로고
    • TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats
    • Tsujihata Y, Ito R, Suzuki M et al. TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats. J Pharmacol Exp Ther 2011; 339: 228-237.
    • (2011) J Pharmacol Exp Ther , vol.339 , pp. 228-237
    • Tsujihata, Y.1    Ito, R.2    Suzuki, M.3
  • 18
    • 0032478314 scopus 로고    scopus 로고
    • Fatty acid-induced β cell apoptosis: a link between obesity and diabetes
    • Shimabukuro M, Zhou YT, Levi M, Unger RH. Fatty acid-induced β cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 1998; 95: 2498-2502.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 2498-2502
    • Shimabukuro, M.1    Zhou, Y.T.2    Levi, M.3    Unger, R.H.4
  • 19
    • 0036153256 scopus 로고    scopus 로고
    • Minireview: secondary β-cell failure in type 2 diabetes-a convergence of glucotoxicity and lipotoxicity
    • Poitout V, Robertson RP. Minireview: secondary β-cell failure in type 2 diabetes-a convergence of glucotoxicity and lipotoxicity. Endocrinology 2002; 143: 339-342.
    • (2002) Endocrinology , vol.143 , pp. 339-342
    • Poitout, V.1    Robertson, R.P.2
  • 20
    • 0026757632 scopus 로고
    • Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations
    • Robertson RP, Zhang HJ, Pyzdrowski KL, Walseth TF. Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations. J Clin Invest 1992; 90: 320-325.
    • (1992) J Clin Invest , vol.90 , pp. 320-325
    • Robertson, R.P.1    Zhang, H.J.2    Pyzdrowski, K.L.3    Walseth, T.F.4
  • 21
    • 39749147110 scopus 로고    scopus 로고
    • Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
    • Muoio DM, Newgard CB. Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol 2008; 9: 193-205.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 193-205
    • Muoio, D.M.1    Newgard, C.B.2
  • 22
    • 20944433543 scopus 로고    scopus 로고
    • The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
    • Steneberg P, Rubins N, Bartoov-Shifman R, Walker MD, Edlund H. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab 2005; 1: 245-258.
    • (2005) Cell Metab , vol.1 , pp. 245-258
    • Steneberg, P.1    Rubins, N.2    Bartoov-Shifman, R.3    Walker, M.D.4    Edlund, H.5
  • 23
    • 58149100292 scopus 로고    scopus 로고
    • Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease
    • Lan H, Hoos LM, Liu L et al. Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease. Diabetes 2008; 57: 2999-3006.
    • (2008) Diabetes , vol.57 , pp. 2999-3006
    • Lan, H.1    Hoos, L.M.2    Liu, L.3
  • 24
    • 34047177401 scopus 로고    scopus 로고
    • GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo
    • Latour MG, Alquier T, Oseid E et al. GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes 2007; 56: 1087-1094.
    • (2007) Diabetes , vol.56 , pp. 1087-1094
    • Latour, M.G.1    Alquier, T.2    Oseid, E.3
  • 25
    • 52249093427 scopus 로고    scopus 로고
    • The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding
    • Kebede M, Alquier T, Latour MG, Semache M, Tremblay C, Poitout V. The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding. Diabetes 2008; 57: 2432-2437.
    • (2008) Diabetes , vol.57 , pp. 2432-2437
    • Kebede, M.1    Alquier, T.2    Latour, M.G.3    Semache, M.4    Tremblay, C.5    Poitout, V.6
  • 26
    • 70350561694 scopus 로고    scopus 로고
    • Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets
    • Alquier T, Peyot ML, Latour MG et al. Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets. Diabetes 2009; 58: 2607-2615.
    • (2009) Diabetes , vol.58 , pp. 2607-2615
    • Alquier, T.1    Peyot, M.L.2    Latour, M.G.3
  • 28
    • 84877623304 scopus 로고    scopus 로고
    • y mice
    • Shima AAF, Shafrir E, eds. Amsterdam: Harwood Academic Publishers
    • y mice. In: Shima AAF, Shafrir E, eds. Animal Models of Diabetes. A Primer. Amsterdam: Harwood Academic Publishers, 2001; 129-142.
    • (2001) Animal Models of Diabetes. A Primer , pp. 129-142
    • Taketomi, S.1    Ikeda, H.2
  • 29
    • 0029742921 scopus 로고    scopus 로고
    • Regulation of obese gene expression in KK mice and congenic lethal yellow obese KKAy mice
    • Hayase M, Ogawa Y, Katsuura G, Shintaku H, Hosoda K, Nakao K. Regulation of obese gene expression in KK mice and congenic lethal yellow obese KKAy mice. Am J Physiol 1996; 271(2 Pt 1): E333-339.
    • (1996) Am J Physiol , vol.271 , Issue.2 PART 1
    • Hayase, M.1    Ogawa, Y.2    Katsuura, G.3    Shintaku, H.4    Hosoda, K.5    Nakao, K.6
  • 30
    • 0021813187 scopus 로고
    • Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 31
  • 32
    • 0032960430 scopus 로고    scopus 로고
    • Lipid infusion lowers sympathetic nervous activity and leads to increased β-cell responsiveness to glucose
    • Magnan C, Collins S, Berthault MF et al. Lipid infusion lowers sympathetic nervous activity and leads to increased β-cell responsiveness to glucose. J Clin Invest 1999; 103: 413-419.
    • (1999) J Clin Invest , vol.103 , pp. 413-419
    • Magnan, C.1    Collins, S.2    Berthault, M.F.3
  • 33
    • 12144291143 scopus 로고    scopus 로고
    • A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli
    • Roduit R, Nolan C, Alarcon C et al. A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes 2004; 53: 1007-1019.
    • (2004) Diabetes , vol.53 , pp. 1007-1019
    • Roduit, R.1    Nolan, C.2    Alarcon, C.3
  • 34
    • 19944434042 scopus 로고    scopus 로고
    • Studies of relationships between variation of the human G protein-coupled receptor 40 gene and type 2 diabetes and insulin release
    • Hamid YH, Vissing H, Holst B et al. Studies of relationships between variation of the human G protein-coupled receptor 40 gene and type 2 diabetes and insulin release. Diabet Med 2005; 22: 74-80.
    • (2005) Diabet Med , vol.22 , pp. 74-80
    • Hamid, Y.H.1    Vissing, H.2    Holst, B.3
  • 35
    • 13844266013 scopus 로고    scopus 로고
    • GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men
    • Ogawa T, Hirose H, Miyashita K, Saito I, Saruta T. GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men. Metabolism 2005; 54: 296-299.
    • (2005) Metabolism , vol.54 , pp. 296-299
    • Ogawa, T.1    Hirose, H.2    Miyashita, K.3    Saito, I.4    Saruta, T.5
  • 36
    • 51649104136 scopus 로고    scopus 로고
    • Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization
    • Vettor R, Granzotto M, De Stefani D et al. Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization. J Clin Endocrinol Metab 2008; 93: 3541-3550.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3541-3550
    • Vettor, R.1    Granzotto, M.2    De Stefani, D.3


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