-
1
-
-
84860217431
-
The functions and regulation of the PTEN tumour suppressor
-
Song MS, Salmena L, Pandolfi PP. The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol 2012; 13: 283-296.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 283-296
-
-
Song, M.S.1
Salmena, L.2
Pandolfi, P.P.3
-
2
-
-
24944568790
-
Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis
-
Chung JH, Eng C. Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer Res 2005; 65: 8096-8100.
-
(2005)
Cancer Res
, vol.65
, pp. 8096-8100
-
-
Chung, J.H.1
Eng, C.2
-
3
-
-
0031001041
-
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
-
Li DM, Sun H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res 1997; 57: 2124-2129.
-
(1997)
Cancer Res
, vol.57
, pp. 2124-2129
-
-
Li, D.M.1
Sun, H.2
-
5
-
-
33845999615
-
Essential role for nuclear PTEN in maintaining chromosomal integrity
-
Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 2007; 128: 157-170.
-
(2007)
Cell
, vol.128
, pp. 157-170
-
-
Shen, W.H.1
Balajee, A.S.2
Wang, J.3
Wu, H.4
Eng, C.5
Pandolfi, P.P.6
-
6
-
-
79953038262
-
PTEN loss in the continuum of common cancers, rare syndromes and mouse models
-
Hollander MC, Blumenthal GM, Dennis PA. PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nature Rev Cancer 2011; 11: 289-301.
-
(2011)
Nature Rev Cancer
, vol.11
, pp. 289-301
-
-
Hollander, M.C.1
Blumenthal, G.M.2
Dennis, P.A.3
-
7
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997; 275: 1943-1947.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
-
8
-
-
84862541350
-
Molecular characterization of endometrial cancer: A correlative study assessing microsatellite instability, MLH1 hypermethylation, DNA mismatch repair protein expression, and PTEN, PIK3CA, KRAS, and BRAF mutation analysis
-
Peterson LM, Kipp BR, Halling Kerr SE, Smith DI, Distad TJ et al. Molecular characterization of endometrial cancer: a correlative study assessing microsatellite instability, MLH1 hypermethylation, DNA mismatch repair protein expression, and PTEN, PIK3CA, KRAS, and BRAF mutation analysis. Int J Gynecol Pathol 2012; 31: 195-205.
-
(2012)
Int J Gynecol Pathol
, vol.31
, pp. 195-205
-
-
Peterson, L.M.1
Kipp, B.R.2
Halling Kerr, S.E.3
Smith, D.I.4
Distad, T.J.5
-
9
-
-
17144436629
-
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997; 15: 356-362.
-
(1997)
Nat Genet
, vol.15
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
Yung, W.K.4
Lin, H.5
Ligon, A.H.6
-
10
-
-
84863393263
-
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
-
Patel JP, Gönen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med 2012; 366: 1079-1089.
-
(2012)
N Engl J Med
, vol.366
, pp. 1079-1089
-
-
Patel, J.P.1
Gönen, M.2
Figueroa, M.E.3
Fernandez, H.4
Sun, Z.5
Racevskis, J.6
-
11
-
-
0033868859
-
Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disorders
-
Aggerholm A, Groønbaek K, Guldberg P, Hokland P. Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disorders. Eur J Haematol 2000; 65: 109-113.
-
(2000)
Eur J Haematol
, vol.65
, pp. 109-113
-
-
Aggerholm, A.1
Groønbaek, K.2
Guldberg, P.3
Hokland, P.4
-
12
-
-
0034101950
-
Mutation analysis of PTEN/ MMAC1 in acute myeloid leukaemia
-
Liu TC, Lin PM, Chang JG, Lee JP, Chen TP, Lin SF. Mutation analysis of PTEN/ MMAC1 in acute myeloid leukaemia. Am J Hematol 2000; 63: 170-175.
-
(2000)
Am J Hematol
, vol.63
, pp. 170-175
-
-
Liu, T.C.1
Lin, P.M.2
Chang, J.G.3
Lee, J.P.4
Chen, T.P.5
Lin, S.F.6
-
13
-
-
36048935750
-
Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: Higher expression of ZAP70 and PKC-beta II in the nongerminal center group and poor survival in patients deficient in nuclear PTEN
-
Fridberg M, Servin A, Anagnostaki L, Linderoth J, Berglund M, Söderberg O et al. Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the nongerminal center group and poor survival in patients deficient in nuclear PTEN. Leuk Lymphoma 2007; 48: 2221-2232.
-
(2007)
Leuk Lymphoma
, vol.48
, pp. 2221-2232
-
-
Fridberg, M.1
Servin, A.2
Anagnostaki, L.3
Linderoth, J.4
Berglund, M.5
Söderberg, O.6
-
14
-
-
51849086880
-
PTEN: A new guardian of the genome
-
Yin Y, Shen WH. PTEN: a new guardian of the genome. Oncogene 2008; 27: 5443-5453.
-
(2008)
Oncogene
, vol.27
, pp. 5443-5453
-
-
Yin, Y.1
Shen, W.H.2
-
15
-
-
53649106156
-
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network
-
Song MS, Salmena L, Carracedo A, Egia A, Lo-Coco F, Teruya-Feldstein J et al. The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature 2008; 455: 813-817.
-
(2008)
Nature
, vol.455
, pp. 813-817
-
-
Song, M.S.1
Salmena, L.2
Carracedo, A.3
Egia, A.4
Lo-Coco, F.5
Teruya-Feldstein, J.6
-
16
-
-
33845977965
-
Ubiquitination regulates PTEN nuclear import and tumor suppression
-
Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H et al. Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 2007; 128: 141-156.
-
(2007)
Cell
, vol.128
, pp. 141-156
-
-
Trotman, L.C.1
Wang, X.2
Alimonti, A.3
Chen, Z.4
Teruya-Feldstein, J.5
Yang, H.6
-
17
-
-
77954914419
-
Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2
-
Mund T, Pelham HR. Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2. Proc Natl Acad Sci USA 2010; 107: 11429-11434.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 11429-11434
-
-
Mund, T.1
Pelham, H.R.2
-
18
-
-
68949121012
-
X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization
-
Van Themsche C, Leblanc V, Parent S, Asselin E. X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization. J Biol Chem 2009; 284: 20462-20466.
-
(2009)
J Biol Chem
, vol.284
, pp. 20462-20466
-
-
Van Themsche, C.1
Leblanc, V.2
Parent, S.3
Asselin, E.4
-
19
-
-
33845991111
-
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN 2007
-
Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z et al. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN 2007Cell 128: 129-139.
-
Cell
, vol.128
, pp. 129-139
-
-
Wang, X.1
Trotman, L.C.2
Koppie, T.3
Alimonti, A.4
Chen, Z.5
Gao, Z.6
-
20
-
-
19944427850
-
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
-
GIMEMA Acute Leukemia Working Party
-
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L et al. GIMEMA Acute Leukemia Working Party. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med 2005; 352: 254-266.
-
(2005)
N Engl J Med
, vol.352
, pp. 254-266
-
-
Falini, B.1
Mecucci, C.2
Tiacci, E.3
Alcalay, M.4
Rosati, R.5
Pasqualucci, L.6
-
21
-
-
33645802652
-
Both carboxyterminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML
-
Falini B, Bolli N, Shan J, Martelli MP, Liso A, Pucciarini A et al. Both carboxyterminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood 2006; 10: 4514-4523.
-
(2006)
Blood
, vol.10
, pp. 4514-4523
-
-
Falini, B.1
Bolli, N.2
Shan, J.3
Martelli, M.P.4
Liso, A.5
Pucciarini, A.6
-
22
-
-
33645526300
-
Delocalization and destabilization of the Arf tumor suppressor by the leukaemia-associated NPM mutant
-
Colombo E, Martinelli P, Zamponi R, Shing DC, Bonetti P, Luzi L et al. Delocalization and destabilization of the Arf tumor suppressor by the leukaemia-associated NPM mutant. Cancer Res 2006; 66: 3044-3050.
-
(2006)
Cancer Res
, vol.66
, pp. 3044-3050
-
-
Colombo, E.1
Martinelli, P.2
Zamponi, R.3
Shing, D.C.4
Bonetti, P.5
Luzi, L.6
-
24
-
-
0032757710
-
Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: Investigation of minimal residual disease in acute leukemia
-
van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G et al. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia 1999; 13: 1901-1928.
-
(1999)
Leukemia
, vol.13
, pp. 1901-1928
-
-
Van Dongen, J.J.1
Macintyre, E.A.2
Gabert, J.A.3
Delabesse, E.4
Rossi, V.5
Saglio, G.6
-
25
-
-
23844546308
-
Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia
-
Noguera NI, Ammatuna E, Zangrilli D, Lavorgna S, Divona M, Buccisano F et al. Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia. Leukemia 2005; 19: 1479-1482.
-
(2005)
Leukemia
, vol.19
, pp. 1479-1482
-
-
Noguera, N.I.1
Ammatuna, E.2
Zangrilli, D.3
Lavorgna, S.4
Divona, M.5
Buccisano, F.6
-
26
-
-
0036850573
-
Alterations of the FLT3 gene in acute promyelocytic leukemia: Association with diagnostic characteristics and analysis of clinical outcome in patients treated with the Italian AIDA protocol
-
Noguera NI, Breccia M, Divona M, Diverio D, Costa V, De Santis S et al. Alterations of the FLT3 gene in acute promyelocytic leukemia: association with diagnostic characteristics and analysis of clinical outcome in patients treated with the Italian AIDA protocol. Leukemia 2002; 16: 2185-2189.
-
(2002)
Leukemia
, vol.16
, pp. 2185-2189
-
-
Noguera, N.I.1
Breccia, M.2
Divona, M.3
Diverio, D.4
Costa, V.5
De Santis, S.6
-
27
-
-
77957192466
-
A monoclonal antibody against mutated nucleophosmin 1 for the molecular diagnosis of acute myeloid leukemias
-
Gruszka AM, Lavorgna S, Consalvo MI, Ottone T, Martinelli C, Cinquanta M et al. A monoclonal antibody against mutated nucleophosmin 1 for the molecular diagnosis of acute myeloid leukemias. Blood 2010; 116: 2096-2102.
-
(2010)
Blood
, vol.116
, pp. 2096-2102
-
-
Gruszka, A.M.1
Lavorgna, S.2
Consalvo, M.I.3
Ottone, T.4
Martinelli, C.5
Cinquanta, M.6
-
28
-
-
77953602479
-
P85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN
-
Anderson DH. p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN. Cell Cycle 2010; 9: 2055-2056.
-
(2010)
Cell Cycle
, vol.9
, pp. 2055-2056
-
-
Anderson, D.H.1
-
29
-
-
77950440345
-
Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3- kinase
-
Chagpar RB, Links PH, Pastor MC, Furber LA, Hawrysh AD, Chamberlain MD et al. Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3- kinase. Proc Natl Acad Sci USA 2010; 107: 5471-5476.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 5471-5476
-
-
Chagpar, R.B.1
Links, P.H.2
Pastor, M.C.3
Furber, L.A.4
Hawrysh, A.D.5
Chamberlain, M.D.6
-
30
-
-
70349311460
-
P85 Associates with unphosphorylated PTEN and the PTEN-associated complex
-
Rabinovsky R, Pochanard P, McNear C, Brachmann SM, Duke-Cohan JS, Garraway LA et al. p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. Mol Cell Biol 2009; 29: 5377-5388.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5377-5388
-
-
Rabinovsky, R.1
Pochanard, P.2
McNear, C.3
Brachmann, S.M.4
Duke-Cohan, J.S.5
Garraway, L.A.6
-
31
-
-
77951234781
-
Ubiquitination of PTEN. (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress
-
Maccario H, Perera NM, Gray A, Downes CP, Leslie NR. Ubiquitination of PTEN. (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress. J Biol Chem2010; 285: 12620-12628.
-
(2010)
J Biol Chem
, vol.285
, pp. 12620-12628
-
-
Maccario, H.1
Perera, N.M.2
Gray, A.3
Downes, C.P.4
Leslie, N.R.5
-
32
-
-
44649190505
-
The PI-3kinase pathway in hematopoietic stem cells and leukaemia-initiating cells: A mechanistic difference between normal and cancer stem cells
-
Yilmaz ÖH, Morrison SJ. The PI-3kinase pathway in hematopoietic stem cells and leukaemia-initiating cells: A mechanistic difference between normal and cancer stem cells. Blood Cells Mol Dis 2008; 41: 73-76.
-
(2008)
Blood Cells Mol Dis
, vol.41
, pp. 73-76
-
-
Yilmaz, Ö.H.1
Morrison, S.J.2
-
33
-
-
79251556241
-
Acute myeloid leukemia with mutated nucleophosmin (NPM1): Is it a distinct entity
-
Falini B, Martelli MP, Bolli N, Ballanti S, Pettirossi V, Martelli MP. Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity? Blood 2011; 117: 1109-1120.
-
(2011)
Blood
, vol.117
, pp. 1109-1120
-
-
Falini, B.1
Martelli, M.P.2
Bolli, N.3
Ballanti, S.4
Pettirossi, V.5
Martelli, M.P.6
-
34
-
-
77953612369
-
Favorable outcome in patients with acute myelogenous leukemia with the nucleophosmin gene mutation autografted after conditioning with high-dose continuous infusion of idarubicin and busulfan
-
Ferrara F, Izzo T, Criscuolo C, Riccardi C, Muccioli G, Viola A et al. Favorable outcome in patients with acute myelogenous leukemia with the nucleophosmin gene mutation autografted after conditioning with high-dose continuous infusion of idarubicin and busulfan. Biol Blood Marrow Transplant 2010; 16: 1018-1024.
-
(2010)
Biol Blood Marrow Transplant
, vol.16
, pp. 1018-1024
-
-
Ferrara, F.1
Izzo, T.2
Criscuolo, C.3
Riccardi, C.4
Muccioli, G.5
Viola, A.6
-
35
-
-
33845483445
-
Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukaemia: Impact on WHO classification 2006
-
Pasqualucci L, Liso A, Martelli MP, Bolli N, Pacini R, Tabarrini A et al. Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukaemia: Impact on WHO classification 2006. Blood 108: 4146-4155.
-
Blood
, vol.108
, pp. 4146-4155
-
-
Pasqualucci, L.1
Liso, A.2
Martelli, M.P.3
Bolli, N.4
Pacini, R.5
Tabarrini, A.6
-
36
-
-
79952450963
-
Non-genomic loss of PTEN function in cancer: Not in my genes
-
Leslie NR, Foti M. Non-genomic loss of PTEN function in cancer: not in my genes. Trends Pharmacol Sci 2011; 32: 131-140.
-
(2011)
Trends Pharmacol Sci
, vol.32
, pp. 131-140
-
-
Leslie, N.R.1
Foti, M.2
|