Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: Higher expression of ZAP70 and PKC-β II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN

Leukemia and Lymphoma

Volumn 48, Issue 11, 2007, Pages 2221-2232

  Fridberg, Marie ^a   Servin, Anna ^a   Anagnostaki, Lola ^a   Linderoth, Johan ^a   Berglund, Mattias ^b   Söderberg, Ola ^b   Enblad, Gunilla ^b   Rosén, Anders ^c   Mustelin, Tomas ^d   Jerkeman, Mats ^a   Persson, Jenny ^a   Wingren, Anette Gjörloff ^a  

^a LUND UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c LINKÖPING UNIVERSITY   (Sweden)

^d BURNHAM INSTITUTE   (United States)

Author keywords

B cell; DLBCL; Germinal center; Lymphoma; PKC ; ZAP70

Indexed keywords

MESSENGER RNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN KINASE C BETA; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; DISEASE SEVERITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LARGE CELL LYMPHOMA; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR CELL;

AGED; CELL NUCLEUS; DIAGNOSIS-RELATED GROUPS; FEMALE; GERMINAL CENTER; HUMANS; LYMPHOMA, LARGE B-CELL, DIFFUSE; MALE; PROGNOSIS; PROTEIN ISOFORMS; PROTEIN KINASE C; PTEN PHOSPHOHYDROLASE; SURVIVAL ANALYSIS; TISSUE ARRAY ANALYSIS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 36048935750     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190701636443     Document Type: Article

References (50)

1. Gatter, K. C. and Warnke, R. A. (2001) Diffuse large B-cell lymphoma. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Haematopoietic and Lymphoid Tissues, pp. 171-174. IARC Press, Lyon
2. Pileri, S. A., Dirnhofer, S., Went, P., Ascani, S., Sabattini, E. and Marafioti, T. (2002) Diffuse large B-cell lymphoma: One or more entities? Present controversies and possible tools for its subclassification. Histopathology, 41, pp. 482-509.
3. Shaffer, A. L., Rosenwald, A. and Staudt, L. M. (2002) Lymphoid malignancies: The dark side of B-cell differentiation. Nat Rev Immunol, 2, pp. 920-932.
4. Sanchez-Beato, M., Sanchez-Aguilera, A. and Piris, M. A. (2003) Cell cycle deregulation in B-cell lymphomas. Blood, 101, pp. 1220-1235.
5. de Leval, L. and Harris, N. L. (2003) Variability in immunophenotype in diffuse large B-cell lymphoma and its clinical relevance. Histopathology, 43, pp. 509-528.
6. Falini, B. and Mason, D. Y. (2002) Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukaemia: Clinical value of their detection by immunocytochemistry. Blood, 99, pp. 409-426.
7. Berglund, M., Enblad, G., Flordal, E., Lui, W., Backlin, C. and Thunberg, U. (2002) Chromosomal imbalances in diffuse large B-cell lymphoma detected by comparative genomic hybridization. Mod Pathol, 15, pp. 807-816.
8. Alizadeh, A. A., Eisen, M. B., Davis, R. E., Lossos, I. S. and Rosenwald, A. (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature, 403, pp. 503-511.
9. Rosenwald, A., Wright, G., Chan, W. C., Connors, J. M., Campo, E. and Fisher, R. I. (2002) The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med, 346, pp. 1937-1947.
10. Wright, G., Tan, B., Rosenwald, A., Hurt, E. H., Wiestner, A. and Staudt, L. M. (2003) A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proc Natl Acad Sci USA, 100, pp. 9991-9996.
11. Chang, C. C., McClintock, S., Cleveland, R. P., Trzpuc, T., Vesole, D. H. and Logan, B. (2004) Immunohistochemical expression patterns of germinal center and activation B-cell markers correlate with prognosis in diffuse large B-cell lymphoma. Am J Surg Pathol, 28, pp. 464-470.
12. Hans, C. P., Weisenburger, D. D., Greiner, T. C., Gascoyne, R. D., Delabie, J. and Ott, G. (2003) Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood, 103, pp. 275-282.
13. Natkunam, Y., Warnke, R. A., Montgomery, K., Falini, B. and van De Rijn, M. (2001) Analysis of MUM1/IRF4 protein expression using tissue microarrays and immunohistochemistry. Mod Pathol, 14, pp. 686-694.
14. Falini, B., Fizzotti, M., Pucciarini, A., Bigerna, B., Marafioti, T. and Gambacorta, M. (2000) A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood, 95, pp. 2084-2092.
15. Bai, M., Agnantis, N. J., Skyrlas, A., Tsanou, E., Kamina, S., Galani, V. and Kanavaros, P. (2003) Increased Expression of the bcl6 and CD10 proteins is associated with increased apoptosis and proliferation in diffuse large B-cell lymphomas. Mod Pathol, 16, pp. 471-480.
16. Martinez-Valdez, H., Guret, C., de Bouteiller, O., Fugier, I., Banchereau, J. and Liu, Y. J. (1996) Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2. J Exp Med, 183, pp. 971-977.
17. Cutrona, G., Dono, M., Pastorino, S., Ulivi, M., Burgio, V. L. and Zupo, S. (1997) The propensity to apoptosis of centrocytes and centroblasts correlates with elevated levels of intracellular myc protein. Eur J Immunol, 27, pp. 234-238.
18. Dono, M., Burgio, V. L., Tacchetti, C., Favre, A., Augliera, A. and Zupo, S. (1996) Subepithelial B cells in the human palatine tonsil. I. Morphologic, cytochemical and phenotypic characterization. Eur J Immunol, 26, pp. 2035-2041.
19. Armitage, J. O. and Weisenburger, D. D. (1998) New approach to classifying non-Hodgkin's lymphomas: Clinical features of the major histologic subtypes. Non-Hodgkin's Lymphoma Classification Project. J Clin Oncol, 16, pp. 2780-2795.
20. Scielzo, C., Camporeale, A., Geuna, M., Alessio, M., Poggi, A. and Zocchi, M. R. (2006) ZAP-70 is expressed by normal and malignant human B-cell subsets of different maturational stage. Leukemia, 20, pp. 689-695.
21. Crespo, M., Villamor, N., Gine, E., Muntanola, A., Colomer, D. and Marafioti, T. (2006) ZAP-70 expression in normal pro/pre B cells, mature B cells, and in B-cell acute lymphoblastic leukemia. Clin Cancer Res, 12, pp. 726-734.
22. Ono, Y., Kikkawa, U. T., Ogita, K., Fujii, T., Kurokawa, T. and Asaoka, Y. (1987) Expression and properties of two types of protein kinase C: alternative splicing from a single gene. Science, 236, pp. 1116-1120.
23. Policha, A., Daneshtalab, N., Chen, L., Dale, L. B., Altier, C. and Khosravani, H. (2006) Role of angiotensin II type 1A receptor phosphorylation, phospholipase D, and extracellular calcium in isoform-specific protein kinase C membrane translocation responses. J Biol Chem, 281, pp. 26340-26349.
24. Shipp, M. A., Ross, K. N., Tamayo, P., Weng, A. P., Kutok, J. L. and Aguiar, R. C. (2002) Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med, 8, pp. 68-74.
25. Hans, C. P., Weisenburger, D. D., Greiner, T. C., Chan, W. C., Aoun, P. and Cochran, G. T. (2005) Expression of PKC-β or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma. Mod Pathol, 18, pp. 1377-1384.
26. Espinosa, I., Briones, J., Bordes, R., Brunet, S., Martino, R. and Sureda, A. (2006) Membrane PKC-β 2 protein expression predicts for poor response to chemotherapy and survival in patients with diffuse large B-cell lymphoma. Ann Hematol, 85, pp. 597-603.
27. Anzelon, A. N. and Rickert, R. C. (2003) Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol, 4, pp. 287-294.
28. Uner, A. H., Saglam, A., Han, U., Hayran, M., Sungur, A. and Ruacan, S. (2005) PTEN and p27 expression in mature T-cell and NK-cell neoplasms. Leuk Lymphoma, 46, pp. 1463-1470.
29. Shen, W. H., Balajee, A. S., Wang, J., Eng, C. and Pandolfi, P. P. (2007) Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell, 128, pp. 157-170.
30. Sun, M., Liu, L. and Zhou, G. W. (2003) The function of the protein tyrosine phosphatase SHP-1 in cancer. Gene, 306, pp. 1-12.
31. Berglund, M., Thunberg, U., Amini, R. M., Book, M., Roos, G. and Erlanson, M. (2005) Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis. Mod Pathol, 18, pp. 1113-1120.
32. Kononen, J., Bubendorf, L., Kallioniemi, A., Barlund, M., Schraml, P. and Leighton, S. (1998) Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med, 4, pp. 844-847.
33. Nilsson, J., Soderberg, O., Nilsson, K. and Rosen, A. (2004) Differentiation-associated redox-regulation in human B cell lines from stem cell/pro-B to plasma cell. Immunol Lett, 94, pp. 83-89.
34. Berglund, M., Thunberg, U., Fridberg, M., Wingren, A Gjörloff, Gullbo, J. and Leuchowius, K. J. (2007) Establishment of a cell line from a chemotherapy resistant diffuse large B-cell lymphoma. Leuk Lymphoma, 48, pp. 1038-1041.
35. Amini, R. M., Berglund, M., Rosenquist, R., Von Heideman, A., Lagercrantz, S. and Thunberg, U. (2002) A novel B-cell line (U-2932) established from a patient with diffuse large B-cell lymphoma following Hodgkin lymphoma. Leuk Lymphoma, 43, pp. 2179-2189.
36. Sambade, C., Berglund, M., Lagercrantz, S., Sallstrom, J., Reis, R. M. and Enblad, G. (2006) U-2940, a human B-cell line derived from a diffuse large cell lymphoma sequential to Hodgkin lymphoma. Int J Cancer, 118, pp. 555-563.
37. Sambade, C., Sallstrom, J., Wiklund, H. J., Enblad, G., Kivi, S. and Gartner, F. (1995) A novel human B-cell line (U-2904) bearing t(8;14) and t(14;18) translocations. Int J Cancer, 63, pp. 710-715.
38. Oken, M. M., Creech, R. H., Tormey, D. C., Horton, J., Davis, T. E. and McFadden, E. T. (1982) Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol, 5, pp. 649-655.
39. Florio, A Di, Capurso, G., Milione, M., Panzuto, F., Geremia, R. and Fave, G. D. (2007) Src family kinase activity regulates adhesion, spreading and migration of pancreatic endocrine tumour cells. Endocr Relat Cancer, 14, pp. 111-124.
40. Teixeira, M. R. (2006) Recurrent fusion oncogenes in carcinomas. Crit Rev Oncog, 12, pp. 257-271.
41. Tautz, L., Pellechia, M. and Mustelin, T. (2006) Targeting the PTPome in human disease. Expert Opin Therapeut Targets, 10, pp. 157-177.
42. Lossos, I. S., Alizadeh, A. A., Diehn, M., Warnke, R., Thorstenson, Y. and Oefner, P. J. (2002) Transformation of follicular lymphoma to diffuse large-cell lymphoma: Alternative patterns with increased or decreased expression of c-myc and its regulated genes. Proc Natl Acad Sci USA, 99, pp. 8886-8891.
43. Gobessi, S., Laurenti, L., Longo, P., Sica, S., Leone, G. and Efremov, D. (2007) ZAP70 enhances B-cell receptor signalling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukaemia and lymphoma B cells. Blood, 109, pp. 2032-2039.
44. Admirand, J. H., Rassidakis, G. Z., Abruzzo, L. V., Valbuena, J. R., Jones, D. and Medeiros, L. J. (2004) Immunohistochemical detection of ZAP-70 in 341 cases of non-Hodgkin and Hodgkin lymphoma. Mod Pathol, 17, pp. 954-961.
45. Carreras, J., Villamor, N., Colomo, L., Moreno, C., Ramon, S., Cajal, y. and Crespo, M. (2005) Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms. J Pathol, 205, pp. 507-513.
46. Gimm, O., Perren, A., Weng, L. P., Marsh, D. J., Yeh, J. J. and Ziebold, U. (2000) Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. Am J Pathol, 156, pp. 1693-1700.
47. Perren, A., Komminoth, P., Saremaslani, P., Matter, C., Feurer, S. and Lee, J. A. (2000) Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells. Am J Pathol, 157, pp. 1097-1103.
48. Li, A. G., Piluso, L. G., Cai, X., Wei, G., Sellers, W. R. and Liu, X. (2006) Mechanistic insights into maintenance of high p53 acetylation by PTEN. Mol Cell, 23, pp. 575-587.
49. Lian, Z. and Cristofano, A Di (2005) Class reunion: PTEN joins the nuclear crew. Oncogene, 24, pp. 7394-7400.
50. Paling, N RD and Welham, M. J. (2005) Tyrosine phosphatase SHP-1 acts at different stages of development to regulate hematopoiesis. Blood, 105, pp. 4290-4297.