Mechanism of action and in vivo efficacy of a human-derived antibody against staphylococcus aureus α-hemolysin

Journal of Molecular Biology

Volumn 425, Issue 10, 2013, Pages 1641-1654

  Foletti, Davide ^a   Strop, Pavel ^a   Shaughnessy, Lee ^a   Hasa Moreno, Adela ^a   Casas, Meritxell Galindo ^a   Russell, Marcella ^a   Bee, Christine ^a   Wu, Si ^a   Pham, Amber ^a   Zeng, Zhilan ^a   Pons, Jaume ^a   Rajpal, Arvind ^a   Shelton, Dave ^a  

^a PFIZER INC   (United States)

Author keywords

animal model; bacterial toxin; crystal structure; pathogen; therapeutic

Indexed keywords

ALPHA HEMOLYSIN; ALPHA HEMOLYSIN ANTIBODY; BACTERIUM ANTIBODY; LINEZOLID; MONOMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ANTIGEN BINDING; ARTICLE; BACTEREMIA; BINDING AFFINITY; CELL MEMBRANE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HUMAN; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN INFECTION; STAPHYLOCOCCAL PNEUMONIA; STAPHYLOCOCCUS AUREUS;

ANIMALIA; BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

EID: 84877581475     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.02.008     Document Type: Article

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