Synthesis of proline analogues as potent and selective cathepsin S inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3140-3144

  Kim, Mira ^a,b   Jeon, Jiyoung ^a   Song, Jiyeon ^a   Suh, Kwee Hyun ^a   Kim, Young Hoon ^a   Min, Kyung Hoon ^b   Lee, Kwang Ok ^a  

^a Hanmi Pharmaceutical Co Ltd   (South Korea)

^b Chung Ang University   (South Korea)

Author keywords

Cathepsin S; Proline analogues; Small molecules

Indexed keywords

CATHEPSIN S INHIBITOR; PROLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DERIVATIZATION; DIASTEREOISOMER; DRUG BIOAVAILABILITY; DRUG METABOLISM; DRUG POTENCY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; NUCLEOPHILICITY; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ARTHRITIS; BENZOXAZOLES; CATHEPSIN B; CATHEPSIN K; CATHEPSINS; COLLAGEN; DISEASE MODELS, ANIMAL; DOGS; ENZYME INHIBITORS; HALF-LIFE; HUMANS; MICE; MICE, INBRED ICR; MICROSOMES; PROLINE; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84877581432     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.023     Document Type: Article

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