Cathepsin S inhibition attenuates neuropathic pain and microglial response associated with spinal cord injury

Open Pain Journal

Volumn 3, Issue 1, 2010, Pages 117-122

  Clark, Anna K ^a   Marchand, Fabien ^a   D' Auria, Marta ^a   Davies, Meirion ^a   Grist, John ^a   Malcangio, Marzia ^a   McMahon, Stephen B ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Chronic pain; Hyperalgesia; Microglia; Protease; Reference

Indexed keywords

EID: 79955657140     PISSN: None     EISSN: 18763863     Source Type: Journal    
DOI: 10.2174/18763863010030400117     Document Type: Article

References (31)

1. Siddall PJ, McClelland JM, Rutkowski SB, Cousins MJ. A longitudinal study of the prevalence and characteristics of pain in the first 5 years following spinal cord injury. Pain 2003; 103: 249-57.
2. Siddall PJ. Management of neuropathic pain following spinal cord injury: now and in the future. Spinal Cord 2009; 47(5): 352-9.
3. Baastrup C, Finnerup NB: Pharmacological management of neuropathic pain following spinal cord injury. CNS Drugs 2008; 22: 455-75.
4. Milligan ED, Watkins LR. Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci 2009; 10: 23-36.
5. McMahon SB, Malcangio M. Current challenges in glia-pain biology. Neuron 2009; 64: 46-54.
6. Clark AK, Yip PK, Grist J, et al. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proc Natl Acad Sci USA 2007; 104: 10655-60.
7. Chang HT. Subacute human spinal cord contusion: few lymphocytes and many macrophages. Spinal Cord 2007; 45: 174-182.
8. Hulsebosch CE, Hains BC, Crown ED, Carlton SM. Mechanisms of chronic central neuropathic pain after spinal cord injury. Brain Res Rev 2009; 60: 202-213.
9. Hains BC, Waxman SG. Activated microglia contribute to the maintenance of chronic pain after spinal cord injury. J Neurosci 2006; 26: 4308-17.
10. Peng XM, Zhou ZG, Glorioso JC, Fink DJ, Mata M. Tumor necrosis factor-alpha contributes to below-level neuropathic pain after spinal cord injury. Ann Neurol 2006; 59: 843-51.
11. Zhao P, Waxman SG, Hains BC. Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin e2 contributes to pain after spinal cord injury. J Neurosci 2007; 27: 2357-68.
12. Zhao P, Waxman SG, Hains BC. Modulation of thalamic nociceptive processing after spinal cord injury through remote activation of thalamic microglia by cysteine cysteine chemokine ligand 21. J Neurosci 2007; 27: 8893-8902.
13. Marchand F, Tsantoulas C, Singh D, et al. Effects of etanercept and minocycline in a rat model of spinal cord injury. Eur J Pain 2009; 13: 673-81.
14. Detloff MR, Fisher LC, McGaughy V, Longbrake EE, Popovich PG, Basso DM. Remote activation of microglia and proinflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats. Exp Neurol 2008; 212: 337-47.
15. Clark AK, Yip PK, Malcangio M. The liberation of fractalkine in the dorsal horn requires microglial cathepsin S. J Neurosci 2009; 29: 6945-54.
16. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988; 32: 77-88.
17. Clark AK, Gentry C, Bradbury EJ, McMahon SB, Malcangio M. Role of spinal microglia in rat models of peripheral nerve injury and inflammation. Eur J Pain 2007; 11: 223-30.
18. Clark AK, Staniland AA, Marchand F, Kaan TKY, McMahon SB, Malcangio M. P2X7-Dependent release of interleukin-1{beta} and nociception in the spinal cord following lipopolysaccharide. J Neurosci 2010; 30: 573-82.
19. Bunge RP, Puckett WR, Becerra JL, Marcillo A, Quencer RM. Observations on the pathology of human spinal cord injury. A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination. Adv Neurol 1993; 59: 75-89.
20. Hulsebosch CE, Xu GY, Perez-Polo JR, Westlund KN, Taylor CP, McAdoo DJ. Rodent model of chronic central pain after spinal cord contusion injury and effects of gabapentin. J Neurotrauma 2000; 17: 1205-17.
21. Mills CD, Hains BC, Johnson KM, Hulsebosch CE. Strain and model differences in behavioral outcomes after spinal cord injury in rat. J Neurotrauma 2001; 18: 743-56.
22. Hains BC, Yucra JA, Hulsebosch CE. Reduction of pathological and behavioral deficits following spinal cord contusion injury with the selective cyclooxygenase-2 inhibitor NS-398. J Neurotrauma 2001; 18: 409-23.
23. Hains BC, Klein JP, Saab CY, Craner MJ, Black JA, Waxman SG. Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury. J Neurosci 2003; 23: 8881-92.
24. Clark AK, Malcangio M. The Cathepsin S/Fractalkine pair: new players in spinal cord neuropathic pain mechanisms. In: Malcangio M, Ed. Synaptic Plasticity in Pain. New York: Springer 2009; pp. 455-71.
25. Leichsenring A, Backer I, Wendt W, et al. Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model. BMC Neurosci 2008; 9: 80.
26. Irie O, Kosaka T, Ehara T, et al. Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain. J Med Chem 2008; 51: 5502-5.
27. Barclay J, Clark AK, Ganju P, et al. Role of the cysteine protease cathepsin S in neuropathic hyperalgesia. Pain 2007; 130: 225-34.
28. Clark AK, Wodarski R, Guida F, Sasso O, Malcangio M. Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor. Glia 2010; DOI: 10.1002/glia.21042.
29. Staniland AA, Clark AK, Wodarski R, et al. Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice. J Neurochem 2010; 14: 1143-57.
30. Gwak YS, Crown ED, Unabia GC, Hulsebosch CE. Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat. Pain 2008; 138: 410-22.
31. Owolabi SA, Saab CY. Fractalkine and minocycline alter neuronal activity in the spinal cord dorsal horn. FEBS Lett 2006; 580: 4306-10.