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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 4, 2013, Pages 1070-1074

Pyrazole-based arylalkyne Cathepsin S inhibitors. Part III: Modification of P4 region

(9) Wiener, John J M a Wickboldt, Alvah Tyson a Nguyen, Steven a Sun, Siquan a Rynberg, Raymond a Rizzolio, Michele a Karlsson, Lars a Edwards, James P a Grice, Cheryl A a

a JANSSEN RESEARCH AND DEVELOPMENT (Belgium)

Author keywords

Alkyne; Autoimmune; Cathepsin S; Pyrazole

Indexed keywords

ALKYNE DERIVATIVE; AMINE; CATHEPSIN S; CATHEPSIN S INHIBITOR; PYRAZOLE DERIVATIVE; SULFIDE;

ARTICLE; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; IC 50; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ALKYNES; CATHEPSINS; HUMANS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872922931 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.12.014 Document Type: Article

Times cited : (11)

References (30)

1
- 41049107484
- S. Gupta, R. Kumar Singh, S. Dastidar, and A. Ray Expert Opin. Ther. Targets 12 2008 291
- (2008) Expert Opin. Ther. Targets , vol.12 , pp. 291
- Gupta, S.¹ Kumar Singh, R.² Dastidar, S.³ Ray, A.⁴

2
- 0033404624
- J.A. Villandangos, R.A.R. Bryant, J. Deussing, C. Driessen, A.-M. Lennon-Dumenil, R.J. Riese, W. Roth, P. Saftig, G.-P. Shi, H.A. Chapman, C. Peters, and H.L. Ploegh Immunol. Rev. 172 1999 109
- (1999) Immunol. Rev. , vol.172 , pp. 109
- Villandangos, J.A.¹ Bryant, R.A.R.² Deussing, J.³ Driessen, C.⁴ Lennon-Dumenil, A.-M.⁵ Riese, R.J.⁶ Roth, W.⁷ Saftig, P.⁸ Shi, G.-P.⁹ Chapman, H.A.¹⁰ Peters, C.¹¹ Ploegh, H.L.¹²

3
- 0033430264
- T.Y. Nakagawa, and A.Y. Rudensky Immunol. Rev. 172 1999 121
- (1999) Immunol. Rev. , vol.172 , pp. 121
- Nakagawa, T.Y.¹ Rudensky, A.Y.²

4
- 0033083688
- G.-P. Shi, J.A. Villadangos, G. Dranoff, C. Small, L. Gu, K.J. Haley, R. Riese, H.L. Ploegh, and H.A. Chapman Immunity 10 1999 197
- (1999) Immunity , vol.10 , pp. 197
- Shi, G.-P.¹ Villadangos, J.A.² Dranoff, G.³ Small, C.⁴ Gu, L.⁵ Haley, K.J.⁶ Riese, R.⁷ Ploegh, H.L.⁸ Chapman, H.A.⁹

5
- 84872979376
- Recent reviews
- Recent reviews: R. Loeoesser Expert Opin. Ther. Pat. 21 2011 585
- (2011) Expert Opin. Ther. Pat. , vol.21 , pp. 585
- Loeoesser, R.¹

6
- 79952050439
- A. Lee-Dutra, D.K. Wiener, and S. Sun Expert Opin. Ther. Pat. 21 2011 311
- (2011) Expert Opin. Ther. Pat. , vol.21 , pp. 311
- Lee-Dutra, A.¹ Wiener, D.K.² Sun, S.³

7
- 77952480430
- J.J.M. Wiener, S. Sun, and R.L. Thurmond Curr. Top. Med. Chem. 10 2010 717
- (2010) Curr. Top. Med. Chem. , vol.10 , pp. 717
- Wiener, J.J.M.¹ Sun, S.² Thurmond, R.L.³

8
- 25844445936
- H. Liu, D.C. Tully, R. Epple, B. Bursulaya, J. Li, J.L. Harris, J.A. Williams, R. Russo, C. Tumanut, M.J. Roberts, P.B. Alper, Y. He, and D.S. Karanewsky Bioorg. Med. Chem. Lett. 15 2005 4979
- (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 4979
- Liu, H.¹ Tully, D.C.² Epple, R.³ Bursulaya, B.⁴ Li, J.⁵ Harris, J.L.⁶ Williams, J.A.⁷ Russo, R.⁸ Tumanut, C.⁹ Roberts, M.J.¹⁰ Alper, P.B.¹¹ He, Y.¹² Karanewsky, D.S.¹³

9
- 32044464952
- P.B. Alper, H. Liu, A.K. Chatterjee, K.T. Nguyen, D.C. Tully, C. Tumanut, J. Li, J.L. Harris, T. Tuntland, J. Chang, P. Gordon, T. Hollenbeck, and D.S. Karanewsky Bioorg. Med. Chem. Lett. 16 2006 1486
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 1486
- Alper, P.B.¹ Liu, H.² Chatterjee, A.K.³ Nguyen, K.T.⁴ Tully, D.C.⁵ Tumanut, C.⁶ Li, J.⁷ Harris, J.L.⁸ Tuntland, T.⁹ Chang, J.¹⁰ Gordon, P.¹¹ Hollenbeck, T.¹² Karanewsky, D.S.¹³

10
- 84886728902
- D.C. Tully, H. Liu, P.B. Alper, A.K. Chatterjee, R. Epple, M.J. Roberts, J.A. Williams, K.T. Nguyen, D.H. Woodmansee, C. Tumanut, J. Li, G. Spraggon, J. Chang, T. Tuntland, J.L. Harris, and D.S. Karanewsky Bioorg. Med. Chem. Lett. 2006 1975 16
- (1975) Bioorg. Med. Chem. Lett. , vol.2006 , pp. 16
- Tully, D.C.¹ Liu, H.² Alper, P.B.³ Chatterjee, A.K.⁴ Epple, R.⁵ Roberts, M.J.⁶ Williams, J.A.⁷ Nguyen, K.T.⁸ Woodmansee, D.H.⁹ Tumanut, C.¹⁰ Li, J.¹¹ Spraggon, G.¹² Chang, J.¹³ Tuntland, T.¹⁴ Harris, J.L.¹⁵ Karanewsky, D.S.¹⁶

11
- 33747354109
- D.C. Tully, H. Liu, A.K. Chatterjee, P.B. Alper, J.A. Williams, M.J. Roberts, D. Mutnick, D.H. Woodmansee, T. Hollenbeck, P. Gordon, J. Chang, T. Tuntland, C. Tumanut, J. Li, J.L. Harris, and D.S. Karanewsky Bioorg. Med. Chem. Lett. 16 2006 5107
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 5107
- Tully, D.C.¹ Liu, H.² Chatterjee, A.K.³ Alper, P.B.⁴ Williams, J.A.⁵ Roberts, M.J.⁶ Mutnick, D.⁷ Woodmansee, D.H.⁸ Hollenbeck, T.⁹ Gordon, P.¹⁰ Chang, J.¹¹ Tuntland, T.¹² Tumanut, C.¹³ Li, J.¹⁴ Harris, J.L.¹⁵ Karanewsky, D.S.¹⁶

12
- 33747373128
- D.C. Tully, H. Liu, A.K. Chatterjee, P.B. Alper, R. Epple, J.A. Williams, M.J. Roberts, D.H. Woodmansee, B.T. Masick, C. Tumanut, J. Li, G. Spraggon, M. Hornsby, J. Chang, T. Tuntland, T. Hollenbeck, P. Gordon, J.L. Harris, and D.S. Karanewsky Bioorg. Med. Chem. Lett. 16 2006 5112
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 5112
- Tully, D.C.¹ Liu, H.² Chatterjee, A.K.³ Alper, P.B.⁴ Epple, R.⁵ Williams, J.A.⁶ Roberts, M.J.⁷ Woodmansee, D.H.⁸ Masick, B.T.⁹ Tumanut, C.¹⁰ Li, J.¹¹ Spraggon, G.¹² Hornsby, M.¹³ Chang, J.¹⁴ Tuntland, T.¹⁵ Hollenbeck, T.¹⁶ Gordon, P.¹⁷ Harris, J.L.¹⁸ Karanewsky, D.S.¹⁹

13
- 34247334237
- A.K. Chatterjee, H. Liu, D.C. Tully, J. Guo, R. Epple, R. Russo, J. Williams, M. Roberts, T. Tuntland, J. Chang, P. Gordon, T. Hollenbeck, C. Tumanut, J. Li, and J.L. Harris Bioorg. Med. Chem. Lett. 17 2007 2899
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 2899
- Chatterjee, A.K.¹ Liu, H.² Tully, D.C.³ Guo, J.⁴ Epple, R.⁵ Russo, R.⁶ Williams, J.⁷ Roberts, M.⁸ Tuntland, T.⁹ Chang, J.¹⁰ Gordon, P.¹¹ Hollenbeck, T.¹² Tumanut, C.¹³ Li, J.¹⁴ Harris, J.L.¹⁵

14
- 78149280634
- J. Cai, J. Robinson, S. Belshaw, K. Everett, X. Fradera, M. van Zeeland, L. van Berkom, P. van Rijnsbergen, L. Popplestone, M. Baugh, M. Dempster, J. Bruin, W. Hamilton, E. Kinghorn, P. Westwood, J. Kerr, W. Arbuckle, D.J. Bennett, P.S. Jones, C. Long, I. Martin, J.C.M. Uitdehaag, and T. Meulemans Bioorg. Med. Chem. Lett. 20 2010 6890
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 6890
- Cai, J.¹ Robinson, J.² Belshaw, S.³ Everett, K.⁴ Fradera, X.⁵ Van Zeeland, M.⁶ Van Berkom, L.⁷ Van Rijnsbergen, P.⁸ Popplestone, L.⁹ Baugh, M.¹⁰ Dempster, M.¹¹ Bruin, J.¹² Hamilton, W.¹³ Kinghorn, E.¹⁴ Westwood, P.¹⁵ Kerr, J.¹⁶ Arbuckle, W.¹⁷ Bennett, D.J.¹⁸ Jones, P.S.¹⁹ Long, C.²⁰ more..

15
- 77955419642
- J. Cai, X. Fradera, M. van Zeeland, M. Dempster, K.S. Cameron, D.J. Bennett, J. Robinson, L. Popplestone, M. Baugh, P. Westwood, J. Bruin, W. Hamilton, E. Kinghorn, C. Long, and J.C.M. Uitdehaag Bioorg. Med. Chem. Lett. 20 2010 4507
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 4507
- Cai, J.¹ Fradera, X.² Van Zeeland, M.³ Dempster, M.⁴ Cameron, K.S.⁵ Bennett, D.J.⁶ Robinson, J.⁷ Popplestone, L.⁸ Baugh, M.⁹ Westwood, P.¹⁰ Bruin, J.¹¹ Hamilton, W.¹² Kinghorn, E.¹³ Long, C.¹⁴ Uitdehaag, J.C.M.¹⁵

16
- 77955426595
- J. Cai, D.J. Bennett, Z. Rankovic, M. Dempster, X. Fradera, J. Gillespie, I. Cumming, W. Finlay, M. Baugh, S. Boucharens, J. Bruin, K.S. Cameron, W. Hamilton, J. Kerr, E. Kinghorn, G. McGarry, J. Robinson, P. Scullion, J.C.M. Uitdehaag, M. van Zeeland, D. Potin, L. Saniere, A. Fouquet, F. Chevallier, H. Deronzier, C. Dorleans, and E. Nicolai Bioorg. Med. Chem. Lett. 20 2010 4447
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 4447
- Cai, J.¹ Bennett, D.J.² Rankovic, Z.³ Dempster, M.⁴ Fradera, X.⁵ Gillespie, J.⁶ Cumming, I.⁷ Finlay, W.⁸ Baugh, M.⁹ Boucharens, S.¹⁰ Bruin, J.¹¹ Cameron, K.S.¹² Hamilton, W.¹³ Kerr, J.¹⁴ Kinghorn, E.¹⁵ McGarry, G.¹⁶ Robinson, J.¹⁷ Scullion, P.¹⁸ Uitdehaag, J.C.M.¹⁹ Van Zeeland, M.²⁰ more..

17
- 77955418622
- J. Cai, M. Baugh, D. Black, C. Long, D.J. Bennett, M. Dempster, X. Fradera, J. Gillespie, F. Anrews, S. Boucharens, J. Bruin, K.S. Cameron, I. Cumming, W. Hamilton, P.S. Jones, A. Kaptein, E. Kinghorn, M. Maidment, I. Martin, A. Mitchell, Z. Rankovic, J. Robinson, P. Scullion, J.C.M. Uitdehaag, P. Vink, P. Westwood, M. van Zeeland, L. van Berkom, M. Bastiani, and T. Meulemans Bioorg. Med. Chem. Lett. 20 2010 4350
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 4350
- Cai, J.¹ Baugh, M.² Black, D.³ Long, C.⁴ Bennett, D.J.⁵ Dempster, M.⁶ Fradera, X.⁷ Gillespie, J.⁸ Anrews, F.⁹ Boucharens, S.¹⁰ Bruin, J.¹¹ Cameron, K.S.¹² Cumming, I.¹³ Hamilton, W.¹⁴ Jones, P.S.¹⁵ Kaptein, A.¹⁶ Kinghorn, E.¹⁷ Maidment, M.¹⁸ Martin, I.¹⁹ Mitchell, A.²⁰ more..

18
- 0037359754
- S.M. Baker, L. Karlsson, and R.L. Thurmond Protein Expr. Purif. 28 2003 93
- (2003) Protein Expr. Purif. , vol.28 , pp. 93
- Baker, S.M.¹ Karlsson, L.² Thurmond, R.L.³

19
- 4544321692
- R.L. Thurmond, M.P. Beavers, H. Cai, S.P. Meduna, D.J. Gustin, S. Sun, H.J. Almond, L. Karlsson, and J.P. Edwards J. Med. Chem. 47 2004 4799
- (2004) J. Med. Chem. , vol.47 , pp. 4799
- Thurmond, R.L.¹ Beavers, M.P.² Cai, H.³ Meduna, S.P.⁴ Gustin, D.J.⁵ Sun, S.⁶ Almond, H.J.⁷ Karlsson, L.⁸ Edwards, J.P.⁹

20
- 9144263557
- R.L. Thurmond, S. Sun, C.A. Sehon, S.M. Baker, H. Cai, Y. Gu, W. Jiang, J.P. Riley, K.N. Williams, J.P. Edwards, and L. Karlsson J. Pharm. Expert Ther. 308 2004 268
- (2004) J. Pharm. Expert Ther. , vol.308 , pp. 268
- Thurmond, R.L.¹ Sun, S.² Sehon, C.A.³ Baker, S.M.⁴ Cai, H.⁵ Gu, Y.⁶ Jiang, W.⁷ Riley, J.P.⁸ Williams, K.N.⁹ Edwards, J.P.¹⁰ Karlsson, L.¹¹

21
- 20044390727
- D.J. Gustin, C.A. Sehon, J. Wei, H. Cai, S.P. Meduna, H. Khatuya, S. Sun, Y. Gu, W. Jiang, R.L. Thurmond, L. Karlsson, and J.P. Edwards Bioorg. Med. Chem. Lett. 15 2005 1687
- (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 1687
- Gustin, D.J.¹ Sehon, C.A.² Wei, J.³ Cai, H.⁴ Meduna, S.P.⁵ Khatuya, H.⁶ Sun, S.⁷ Gu, Y.⁸ Jiang, W.⁹ Thurmond, R.L.¹⁰ Karlsson, L.¹¹ Edwards, J.P.¹²

22
- 33644815279
- C.A. Grice, K. Tays, H. Khatuya, D.J. Gustin, C.R. Butler, J. Wei, C.A. Sehon, S. Sun, Y. Gu, W. Jiang, R.L. Thurmond, L. Karlsson, and J.P. Edwards Bioorg. Med. Chem. Lett. 16 2006 2209
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 2209
- Grice, C.A.¹ Tays, K.² Khatuya, H.³ Gustin, D.J.⁴ Butler, C.R.⁵ Wei, J.⁶ Sehon, C.A.⁷ Sun, S.⁸ Gu, Y.⁹ Jiang, W.¹⁰ Thurmond, R.L.¹¹ Karlsson, L.¹² Edwards, J.P.¹³

23
- 34548580127
- J. Wei, B.A. Pio, H. Cai, S.P. Meduna, S. Sun, Y. Gu, W. Jiang, R.L. Thurmond, L. Karlsson, and J.P. Edwards Bioorg. Med. Chem. Lett. 17 2007 5525
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 5525
- Wei, J.¹ Pio, B.A.² Cai, H.³ Meduna, S.P.⁴ Sun, S.⁵ Gu, Y.⁶ Jiang, W.⁷ Thurmond, R.L.⁸ Karlsson, L.⁹ Edwards, J.P.¹⁰

24
- 77949486200
- J.J.M. Wiener, A.T. Wickboldt, D.K. Wiener, A. Lee-Dutra, J.P. Edwards, L. Karlsson, S. Nguyen, S. Sun, S. Bembenek, T.K. Jones, and C.A. Grice Bioorg. Med. Chem. Lett. 20 2010 2375
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 2375
- Wiener, J.J.M.¹ Wickboldt, A.T.² Wiener, D.K.³ Lee-Dutra, A.⁴ Edwards, J.P.⁵ Karlsson, L.⁶ Nguyen, S.⁷ Sun, S.⁸ Bembenek, S.⁹ Jones, T.K.¹⁰ Grice, C.A.¹¹

25
- 77949486207
- A. Lee-Dutra, D.K. Wiener, K.L. Arienti, J. Liu, N. Mani, M.K. Ameriks, F.U. Axe, D. Gebauer, P.J. Desai, S. Nguyen, M. Randal, R.L. Thurmond, S. Sun, L. Karlsson, J.P. Edwards, T.K. Jones, and C.A. Grice Bioorg. Med. Chem. Lett. 20 2010 2370
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 2370
- Lee-Dutra, A.¹ Wiener, D.K.² Arienti, K.L.³ Liu, J.⁴ Mani, N.⁵ Ameriks, M.K.⁶ Axe, F.U.⁷ Gebauer, D.⁸ Desai, P.J.⁹ Nguyen, S.¹⁰ Randal, M.¹¹ Thurmond, R.L.¹² Sun, S.¹³ Karlsson, L.¹⁴ Edwards, J.P.¹⁵ Jones, T.K.¹⁶ Grice, C.A.¹⁷

26
- 71749093965
- M.K. Ameriks, F.U. Axe, S.D. Bembenek, J.P. Edwards, Y. Gu, L. Karlsson, M. Randal, S. Sun, R.L. Thurmond, and J. Zhu Bioorg. Med. Chem. Lett. 19 2009 6131
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 6131
- Ameriks, M.K.¹ Axe, F.U.² Bembenek, S.D.³ Edwards, J.P.⁴ Gu, Y.⁵ Karlsson, L.⁶ Randal, M.⁷ Sun, S.⁸ Thurmond, R.L.⁹ Zhu, J.¹⁰

27
- 71749118110
- M.K. Ameriks, H. Cai, J.P. Edwards, D. Gebauer, E. Gleason, Y. Gu, L. Karlsson, S. Nguyen, S. Sun, R.L. Thurmond, and J. Zhu Bioorg. Med. Chem. Lett. 19 2009 6135
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 6135
- Ameriks, M.K.¹ Cai, H.² Edwards, J.P.³ Gebauer, D.⁴ Gleason, E.⁵ Gu, Y.⁶ Karlsson, L.⁷ Nguyen, S.⁸ Sun, S.⁹ Thurmond, R.L.¹⁰ Zhu, J.¹¹

28
- 77949794105
- X. Deng, J.T. Liang, M. Peterson, R. Rynberg, E. Cheung, and N.S. Mani J. Org. Chem. 2010 1940 75
- (1940) J. Org. Chem. , vol.2010 , pp. 75
- Deng, X.¹ Liang, J.T.² Peterson, M.³ Rynberg, R.⁴ Cheung, E.⁵ Mani, N.S.⁶

29
- 84872965077
- Manuscript in preparation
- Sun, S.; Eckert, W. A., III; Wiener, J. J. M.; Fung-Lung, W.-P.; Cai, H.; Ameriks, M. K.; Zhu, J.; Gu, Y.; Ngo, K.; Gebauer, D.; Nguyen, S.; Thurmond, R. L.; Grice, C. A.; Edwards, J. P.; Karlsson, L. Immune modulation and analgesic activity of a selective, non-covalent Cathepsin S inhibitor in mice. Manuscript in preparation.
- Immune Modulation and Analgesic Activity of A Selective, Non-covalent Cathepsin S Inhibitor in Mice
- Sun, S.¹ Eckert, W.A.² Wiener, J.J.M.³ Fung-Lung, W.-P.⁴ Cai, H.⁵ Ameriks, M.K.⁶ Zhu, J.⁷ Gu, Y.⁸ Ngo, K.⁹ Gebauer, D.¹⁰ Nguyen, S.¹¹ Thurmond, R.L.¹² Grice, C.A.¹³ Edwards, J.P.¹⁴ Karlsson, L.¹⁵

30
- 28144452675
- J.-P. Falgueyret, S. Desmarais, R. Oballa, W.C. Black, W. Cromlish, K. Khougaz, S. Lamontagne, F. Masse, D. Riendeau, S. Toulmond, and M.D. Percival J. Med. Chem. 48 2005 7535
- (2005) J. Med. Chem. , vol.48 , pp. 7535
- Falgueyret, J.-P.¹ Desmarais, S.² Oballa, R.³ Black, W.C.⁴ Cromlish, W.⁵ Khougaz, K.⁶ Lamontagne, S.⁷ Masse, F.⁸ Riendeau, D.⁹ Toulmond, S.¹⁰ Percival, M.D.¹¹

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