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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3257-3261

Modular, efficient synthesis of asymmetrically substituted piperazine scaffolds as potent calcium channel blockers

(6) Borzenko, Andrey a Pajouhesh, Hassan b Morrison, Jerrie Lynn b Tringham, Elizabeth b Snutch, Terrance P c Schafer, Laurel L a

a UNIVERSITY OF BRITISH COLUMBIA (Canada)

b Zalicus Pharmaceuticals Ltd (Canada)

c UNIVERSITY OF BRITISH COLUMBIA (Canada)

Author keywords

L type calcium channel; N type calcium channel; Substituted piperazines; Titanium catalysis; Zirconium catalysis

Indexed keywords

1 BENZHYDRYL 5 METHYLPIPERAZIN 2 YL)BUTAN 1 OL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; PIPERAZINE DERIVATIVE; TITANIUM; UNCLASSIFIED DRUG; ZIRCONIUM;

ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HYDROGEN BOND; IC 50; NONHUMAN; STEREOCHEMISTRY;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, N-TYPE; CATALYSIS; CELL LINE; HUMANS; PIPERAZINES; PROTEIN BINDING; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TITANIUM; ZIRCONIUM;

EID: 84877577191 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.03.114 Document Type: Article

Times cited : (14)

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