Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 15, 2006, Pages 5333-5339

  Yamamoto, Takashi ^a   Niwa, Seiji ^a   Iwayama, Satoshi ^a   Koganei, Hajime ^a   Fujita, Shin ichi ^a   Takeda, Tomoko ^a   Kito, Morikazu ^a   Ono, Yukitsugu ^a   Saitou, Yuki ^a   Takahara, Akira ^a   Iwata, Seinosuke ^a   Yamamoto, Hiroshi ^a   Shoji, Masataka ^a  

^a AJINOMOTO CO INC   (Japan)

Author keywords

Analgesic activity; Cyproheptadine; N type calcium channel; Structure activity relationship study

Indexed keywords

ANALGESIC AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CYPROHEPTADINE; HISTAMINE; N [3 [4 (5H DIBENZO[A,D]CYCLOHEPTEN 5 YLIDENE) 1 PIPERIDINYL] 3 OXOPROPYL] 2,2 DIMETHYLPROPANAMIDE; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL STRUCTURE; CORRELATION ANALYSIS; DRUG EFFICACY; DRUG STRUCTURE; NONHUMAN; PAIN; RAT;

ADMINISTRATION, ORAL; ANIMALS; BEHAVIOR, ANIMAL; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; CELL LINE, TUMOR; CYPROHEPTADINE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FORMALDEHYDE; GUINEA PIGS; HUMANS; MALE; MOLECULAR STRUCTURE; PAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, HISTAMINE; RECEPTORS, SEROTONIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 33745138593     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.03.040     Document Type: Article

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