Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 4153-4158

  Pajouhesh, Hassan ^a   Feng, Zhong Ping ^a,b,f   Zhang, Lingyun ^a   Pajouhesh, Hossein ^a   Jiang, Xinpo ^a,g   Hendricson, Adam ^a,h   Dong, Haiheng ^a,i   Tringham, Elizabeth ^a   Ding, Yanbing ^a,j   Vanderah, Todd W ^c   Porreca, Frank ^c   Belardetti, Francesco ^a   Zamponi, Gerald W ^b   Mitscher, Lester A ^d   Snutch, Terrance P ^e  

^a Zalicus Pharmaceuticals Ltd   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF KANSAS   (United States)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

^g Genscript Technology Co Ltd   (China)

^h BRISTOL MYERS SQUIBB   (United States)

ⁱ WUXI APPTEC   (China)

^j Shanghai ChemPartner Co Ltd   (China)

more..

Author keywords

hERG potassium channel; L Type calcium channel; N Type calcium channel; Pain; Trimethoxybenzyl piperazine

Indexed keywords

ANTINOCICEPTIVE AGENT; CALCIUM CHANNEL BLOCKING AGENT; NP 078585; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; INFLAMMATORY PAIN; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; RAT; SPINAL NERVE; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, N-TYPE; DISEASE MODELS, ANIMAL; ETHER-A-GO-GO POTASSIUM CHANNELS; HYPERALGESIA; NEURALGIA; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; SPINAL NERVES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; RATTUS;

EID: 84861579001     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.054     Document Type: Article

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