IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A

Journal of Human Genetics

Volumn 46, Issue 1, 2001, Pages 21-25

  Sugimoto, N ^a   Imoto, I ^a   Fukuda, Y ^a   Kurihara, N ^a   Kuroda, S ^c   Tanigami, A ^d   Kaibuchi, K ^c   Kamiyama, R ^b   Inazawa, J ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^d OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Catenin; 15q26; Gastric cancer; Gene amplification; IQGAPI

Indexed keywords

BETA CATENIN; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; UVOMORULIN;

ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CHROMOSOME 15Q; EXPRESSED SEQUENCE TAG; GENE AMPLIFICATION; GENE EXPRESSION; GENE LOCATION; GENE TARGETING; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; STOMACH CANCER;

CARRIER PROTEINS; CHROMOSOMES, HUMAN, PAIR 15; DNA, COMPLEMENTARY; GENE AMPLIFICATION; HUMANS; RAS GTPASE-ACTIVATING PROTEINS; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0035111088     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380170119     Document Type: Article

References (25)

1. Assembly of the cadherin-catenin complex in vitro with recombinant proteins
2. The insulin-like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer
3. DNA copy number changes and evaluation of MYC, IGF1R, and FES amplification in xenografts of pancreatic adenocarcinoma
4. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas
5. Sporadic amplification of the insulin-like growth factor I receptor gene in human breast tumors
6. Regulation of cross-linking of actin filament by IQGAP1, a target for cdc42
7. Cdc42 and Racl regulate the interaction of IQGAP1 with betacatenin
8. CD44 is a potential target of amplification within the 11p13 amplicon detected in four of 25 gastric-cancer cell lines
9. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers
10. High resolution cytogenetic mapping of 342 markers including 43 RFLP markers on human chromosome 17 by fluorescence in situ hybridization
11. Abnormal expression and function of the E-cadherin-catenin complex in gastric carcinoma cell lines
12. Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the β-catenin gene in a human cancer cell line. HSC-39
13. DNA copy number losses in human neoplasms
14. Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Racl
15. Role of IQGAPI, a target of the small GTPases Cdc42 and Racl, in regulation of E-cadherin-mediated cell-cell adhesion
16. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
17. Detection of DNA amplification in 17 primary breast carcinomas with homogeneously staining regions by a modified comparative genomic hybridization technique
18. A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: A cause of loss of intercellular adhesiveness in human cancer cell lines
19. Improved tools for biological sequence comparison
20. Identification of a novel gene, MASL1, within an amplicon at 8p23.1 detected in malignant fibrous histiocytomas by comparative genomic hybridization
21. Molecular biology of gastric cancer
22. E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas
23. Identification of a human rasGAP-related protein containing calmodulin-binding motifs
24. Establishment and characterization of human signet ring cell gastric carcinoma cell lines with amplification of the c-myc oncogene
25. Rapid isolation and characterization of amplified DNA by chromosome microdissection: Identification of IGF1R amplification in malignant melanoma