Residence time distribution, a simple tool to understand the behaviour of polymeric mini-flow reactors

RSC Advances

Volumn 2, Issue 23, 2012, Pages 8721-8728

  Sans, Victor ^a,b   Karbass, Naima ^a   Burguete, M Isabel ^a   García Verdugo, Eduardo ^a   Luis, Santiago V ^a  

^a UNIVERSITAT JAUME I   (Spain)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL REACTORS; DISPERSIONS; FLOW PATTERNS; FUNCTIONAL MATERIALS; POLYMERS;

AXIAL DISPERSION MODEL; BACKBONE STRUCTURES; CATALYTIC EFFICIENCIES; CLEAN TECHNOLOGIES; CONTINUOUS FLOW REACTORS; DIFFERENT STRUCTURE; MONOLITHIC COLUMNS; QUANTITATIVE COMPARISON;

RESIDENCE TIME DISTRIBUTION;

EID: 84877312862     PISSN: None     EISSN: 20462069     Source Type: Journal    
DOI: 10.1039/c2ra20903a     Document Type: Article

References (69)

1. S. V. Luis and E. García-Verdugo, Chemical Reactions and Processes under Flow Conditions, Royal Society of Chemistry, Cambridge, 2009.
2. (a) K. Geyer, T. Gustafsson and P. H. Seeberger, Synlett, 2009, 15, 2382;
3. (b) H. Kim, A. Nagaki and J. I. Yoshida, Nat. Commun., 2011, 2, 264;
4. (c) T. Razzaq and C. O. Kappe, Chem. Asian. J., 2011, 5, 1274.
5. C. G. Frost and L. Mutton, Green Chem., 2010, 12, 1687.
6. (a) I. Baxendale, S. Schou, J. Sedelmeier and S. Ley, Chem.-Eur. J., 2010, 16, 89;
7. (b) D. Webb and T. F. Jamison, Chem. Sci., 2010, 1, 675;
8. (c) F. Venturoni, N. Nikbin, S. V. Ley and I. R. Baxendale, Org. Biomol. Chem., 2010, 8, 1798.
9. (a) N. G. Anderson, Org. Process Res. Dev., 2001, 5, 613;
10. (b) P. Watts and S. J. Haswell, Drug Discovery Today, 2003, 8, 586;
11. (c) V. Bavykin, A. A. Lapkin, S. T. Kolaczkowski and P. K. Plucinski, Appl. Catal., A, 2005, 288, 175;
12. (d) T. Glasnov, S. Findenig and C. Kappe, Chem.-Eur. J., 2009, 15, 1001;
13. (e) B. Ngamsom, A. M. Hickey, G. M. Greenway, J. A. Littlechild, T. McCreedy, P. Watts and C. Wiles, Org. Biomol. Chem., 2010, 8, 2419.
14. (a) M.H. C. L. Dressen, B.H. P. van de Kruijs, J. Meuldijk, J. A. J. M. Vekemans and L. A. Hulshof, Org. Process Res. Dev., 2010, 14, 351;
15. (b) U. Hintermair, G. Francio and W. Leitner, Chem. Commun., 2011, 47, 3691.
16. (a) A. Kirschning and G. Jas, Top. Curr. Chem., 2004, 242, 209;
17. (b) P. Hodge, Ind. Eng. Chem. Res., 2005, 44, 8542.
18. S. Kataoka, Y. Takeuchi, A. Harada, M. Yamada and A. Endo, Green Chem., 2010, 12, 331.
19. (a) K. Geyer, J. D. C. Codée and P. H. Seeberger, Chem.-Eur. J., 2006, 12, 8434;
20. (b) G. Jas and A. Kirschning, Chem.-Eur. J., 2003, 9, 5708.
21. (a) J. P. McMullen, M. T. Stone, S. L. Buchwald and K. F. Jensen, Angew. Chem., Int. Ed., 2010, 49, 7076;
22. (b) M. Rasheed and T. Wirth, Angew. Chem., Int. Ed., 2011, 50, 357;
23. (c) A. J. Parrott, R. A. Bourne, G. R. Akien, D. J. Irvine and M. Poliakoff, Angew. Chem., Int. Ed., 2011, 50, 3788.
24. (a) N. Wang, T. Matsumoto, M. Ueno, H. Miyamura and S. Kobayashi, Angew. Chem., Int. Ed., 2009, 48, 4744;
25. (b) F. Costantini, E. M. Benetti, R. M. Tiggelaar, H. J. G. E. Gardeniers, D. N. Reinhoudt, J. Huskens, G. J. Vancso and W. Verboom, Chem.-Eur. J., 2010, 16, 12406;
26. (c) J. F Ng, Y. Nie, G. K. Chuah and S. Jaenicke, J. Catal., 2010, 269, 302.
27. (a) A. Sachse, A. Galarneau, B. Coq and F. Fajula, New J. Chem., 2011, 35, 259;
28. (b) A. Sachse, A. Galarneau, F. Fajula, F. Di Renzo, P. Creux and B. Coq, Microporous Mesoporous Mater., 2011, 140, 58;
29. (c) A. Sachse, A. Galarneau, F. Di Renzo, F. Fajula and B. Coq, Chem. Mater., 2010, 22, 4123.
30. (a) M. I. Burguete, H. Erythropel, E. García-Verdugo, S. V. Luis and V. Sans, Green Chem., 2008, 10, 401;
31. (b) M. Baumann, I. R. Baxendale, S. V. Ley, N. Nikbin and C. D. Smith, Org. Biomol. Chem., 2008, 6, 1587;
32. (c) H. Lange, M. J. Capener, A. X. Jones, C. J. Smith, N. Nikbin, I. R. Baxendale and S. V. Ley, Synlett, 2011, 869;
33. (d) C. J. Smith, C. D. Smith, N. Nikbin, S. V. Ley and I. R. Baxendale, Org. Biomol. Chem., 2011, 9, 1927;
34. (e) J. A. Tripp, T. P. Needham, E. M. Ripp, B. G. Konzman and P. J. Homnick, React. Funct. Polym., 2010, 70, 414.
35. (a) B. Altava, M. I. Burguete, E. García-Verdugo, S. V. Luis and M. J. Vicent, Green Chem., 2006, 8, 717;
36. (b) M. I. Burguete, A. Cornejo, E. García-Verdugo, J. I. Garcia, M. J. Gil, S. V. Luis, V. Martinez-Merino, J. A. Mayoral and M. Sokolova, Green Chem., 2007, 9, 1091;
37. (c) M. I. Burguete, A. Cornejo, E. García-Verdugo, M. J. Gil, S. V. Luis, J. A. Mayoral, V. Martinez-Merino and M. Sokolova, J. Org. Chem., 2007, 72, 4344;
38. (d) A. Gömanna, J. A. Deverell, K. F. Munting, R. C. Jones, T. Rodemann, A. J. Canty, J. A. Smith and R. M. Guijt, Tetrahedron, 2009, 65, 1450;
39. (e) B. Ngamsom, A. M. Hickey, G. M. Greenway, J. A. Littlechild, P. Watts and C. Wiles, J. Mol. Catal. B: Enzym., 2010, 63, 81;
40. (f) C. Aranda, A. Cornejo, J. M. Fraile, E. García-Verdugo, M. J. Gil, S. V. Luis, J. A. Mayoral, V. Martinez-Merino and Z. Ochoa, Green Chem., 2011, 13, 983.
41. A. El Kadib, R. Chimenton, A. Sachse, F. Fajula, A. Galarneau and B. Coq, Angew. Chem., Int. Ed., 2009, 48, 4969.
42. (a) A. R. Bogdan, B. P. Mason, K. T. Sylvester and D. T. McQuade, Angew. Chem., Int. Ed., 2007, 46, 1698;
43. (b) A. R. Bogdan and D. T. McQuade, Beilstein J. Org. Chem., 2009, 5, 17.
44. J. Wegner, S. Ceylan and A. Kirschning, Chem. Commun., 2011, 47, 4583.
45. J. A. Tripp, F. Svec and J. M. J. Frechet, J. Comb. Chem., 2001, 3, 216.
46. B. Altava, M. I. Burguete, E. García-Verdugo, S. V. Luis and M. J. Vicent, Tetrahedron, 2001, 57, 8675.
47. N. Karbass, V. Sans, E. García-Verdugo, M. I. Burguete and S. V. Luis, Chem. Commun., 2006, 3095.
48. C. Wiles, P. Watts and S. J. Haswell, Tetrahedron, 2004, 60, 8421.
49. J. Lu and P. H. Toy, Chem. Rev., 2009, 109, 815.
50. (a) P. Lozano, E. García-Verdugo, R. Piamtongkam, N. Karbass, T. De Diego, M. I. Burguete, S. V. Luis and J. L. Iborra, Adv. Synth. Catal., 2007, 349, 1077;
51. (b) P. Lozano, E. García-Verdugo, N. Karbass, K. Montague, T. De Diego, M. I. Burguete and S. V. Luis, Green Chem., 2010, 12, 1803;
52. (c) M. I. Burguete, E. García-Verdugo, I. Garcia-Villar, F. Gelat, P. Licence, S. V. Luis and V. Sans, J. Catal., 2010, 269, 150;
53. (d) V. Sans, F. Gelat, N. Karbass, M. I. Burguete, E. García-Verdugo and S. V. Luis, Adv. Synth. Catal., 2010, 352, 3013.
54. M. I. Burguete, E. García-Verdugo, S. V. Luis and J. A. Restrepo, Phys. Chem. Chem. Phys., 2011, 13, 14831.
55. The residence time distribution (RTD) of a chemical reactor is a probability distribution function that describes the amount of time a fluid element could spend inside the reactor.
56. K. Pangarkar, T. J. Schildhauer, J. R. van Ommen, J. Nijenhuis, F. Kapteijn and J. A. Moulijn, Ind. Eng. Chem. Res., 2008, 47, 3720.
57. R. B. MacMullin and M. Weber Jr., Trans. Am. Inst. Chem. Eng., 1935, 31, 409.
58. P. V. Danckwerts, Chem. Eng. Sci., 1953, 2, 1.
59. M. Gavrilescu and R. Z. Tudose, Chem. Eng. Process., 1999, 38, 225.
60. S. H. Fogler, Elements of Chemical Reaction Engineering, Prentice Hall International, New Jersey, 4th edn, 2005.
61. A flow tracer is any fluid property used to track flow. The concentration of a chemical compound in the fluid can be used as a chemical tracer, and characteristics such as temperature are physical tracers. Tracers may be artificially introduced, like dye tracers, or they may be naturally occurring. Conservative tracers remain constant following fluid parcels, whereas reactive tracers (such as compounds undergoing a mutual chemical reaction) grow or decay with time.
62. O. Levenspiel, Chemical Reaction Engineering, Wiley, 3rd edn, 1999.
63. A. P. Kybett and D. C. Sherrington, Supported Catalysts and their Applications, The Royal Society of Chemistry, Oxford, 2001.
64. (a) E. Alza, C. Rodríguez-Escrich, S. Sayalero, A. Bastero and M. A Pericàs, Chem.-Eur. J., 2009, 15, 10167;
65. (b) M. A. Pericaàs, C. I. Herreriàas and L. Solaà, Adv. Synth. Catal., 2008, 350, 927-932.
66. (a) C. Viklund, F. Svec, J. M. J. Fréchet and K. Irgum, Chem.Mater., 1996, 8, 744;
67. (b) F. Svec, J. Chromatogr., A, 2010, 1217, 902.
68. D. A. Mair, T. R. Schwei, T. S. Dinio, F. Svec and J. M. J. Frechet, Lab Chip, 2009, 9, 877.
69. A. A. Yawalkar, R. Sood, M. T. Kreutzer, F. Kapteijn and J. A. Moulijn, Ind. Eng. Chem. Res., 2005, 44, 2046.