Practical use of continuous processing in developing and scaling up laboratory processes

Organic Process Research and Development

Volumn 5, Issue 6, 2001, Pages 613-621

  Anderson, Neal G ^a  

^a Anderson's Process Solutions   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035563923     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0100605     Document Type: Article

References (123)

1. Anderson, N. G. Practical Process Research & Development; Academic Press: San Diego, 2000. This review expands upon material found primarily in Chapter 13.
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3. For discussion cf micromixing, mesomixing, and macromixing, see: Baldyga, J.; Pohorecki, R. Turbulent micromixing in chemical reactors: a review. Chem. Eng. J. 1995, 58, 183; Baldyga, J.; Bourne, J. R. Turbulent Mixing and Chemical Reactions; Wiley: New York, 1999; Atherton, J. H.; Carpenter, K. Process Development: Physicochemical Concepts; Oxford University Press: Oxford, 1999; Handbook of Batch Process Design; Sharratt, P. N., Ed.; Blackie/Chapman & Hall: New York, 1997; Genck, W. J. Crystallization's Forgotten Facet. Chem. Eng. 1997, 104(10), 94.
4. For discussion cf micromixing, mesomixing, and macromixing, see: Baldyga, J.; Pohorecki, R. Turbulent micromixing in chemical reactors: a review. Chem. Eng. J. 1995, 58, 183; Baldyga, J.; Bourne, J. R. Turbulent Mixing and Chemical Reactions; Wiley: New York, 1999; Atherton, J. H.; Carpenter, K. Process Development: Physicochemical Concepts; Oxford University Press: Oxford, 1999; Handbook of Batch Process Design; Sharratt, P. N., Ed.; Blackie/Chapman & Hall: New York, 1997; Genck, W. J. Crystallization's Forgotten Facet. Chem. Eng. 1997, 104(10), 94.
5. For discussion cf micromixing, mesomixing, and macromixing, see: Baldyga, J.; Pohorecki, R. Turbulent micromixing in chemical reactors: a review. Chem. Eng. J. 1995, 58, 183; Baldyga, J.; Bourne, J. R. Turbulent Mixing and Chemical Reactions; Wiley: New York, 1999; Atherton, J. H.; Carpenter, K. Process Development: Physicochemical Concepts; Oxford University Press: Oxford, 1999; Handbook of Batch Process Design; Sharratt, P. N., Ed.; Blackie/Chapman & Hall: New York, 1997; Genck, W. J. Crystallization's Forgotten Facet. Chem. Eng. 1997, 104(10), 94.
6. For discussion cf micromixing, mesomixing, and macromixing, see: Baldyga, J.; Pohorecki, R. Turbulent micromixing in chemical reactors: a review. Chem. Eng. J. 1995, 58, 183; Baldyga, J.; Bourne, J. R. Turbulent Mixing and Chemical Reactions; Wiley: New York, 1999; Atherton, J. H.; Carpenter, K. Process Development: Physicochemical Concepts; Oxford University Press: Oxford, 1999; Handbook of Batch Process Design; Sharratt, P. N., Ed.; Blackie/Chapman & Hall: New York, 1997; Genck, W. J. Crystallization's Forgotten Facet. Chem. Eng. 1997, 104(10), 94.
7. On a large scale, minutes of mixing may be required to reach equilibrium conditions throughout a vessel. For instance, as much as 5 min may be needed for pH stabilization in a 200-gal reactor.
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9. See review of ref 4: Laird, T. Org. Process Res. Dev. 2001, 5, 89.
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11. Reference 4, p 9.
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14. For detailed discussions, see Oldshue, J. Y. Fluid Mixing Technology; McGraw-Hill: New York, 1983; Levenspiel, O. Chemical Reaction Engineering, 3rd ed.; John Wiley & Sons: New York, 1999; Denbigh, K. G.; Turner, J. C. R. Chemical Reactor Theory, 3rd ed.; Cambridge University Press: Cambridge, 1984; Walas, S. M. Chemical Reactors. In Perry's Chemical Engineer's Handbook, 7th ed.; Perry, R. H., Green, D. W., Maloney, J. O., Eds.; McGraw-Hill: New York, 1997; pp 23-61; Scaleup of Chemical Processes. Conversion from Laboratory Scale Tests to Successful Commercial Size Design; Bisio, A., Kabel, R. L., Eds.; Wiley: New York, 1985.
15. For detailed discussions, see Oldshue, J. Y. Fluid Mixing Technology; McGraw-Hill: New York, 1983; Levenspiel, O. Chemical Reaction Engineering, 3rd ed.; John Wiley & Sons: New York, 1999; Denbigh, K. G.; Turner, J. C. R. Chemical Reactor Theory, 3rd ed.; Cambridge University Press: Cambridge, 1984; Walas, S. M. Chemical Reactors. In Perry's Chemical Engineer's Handbook, 7th ed.; Perry, R. H., Green, D. W., Maloney, J. O., Eds.; McGraw-Hill: New York, 1997; pp 23-61; Scaleup of Chemical Processes. Conversion from Laboratory Scale Tests to Successful Commercial Size Design; Bisio, A., Kabel, R. L., Eds.; Wiley: New York, 1985.
16. For detailed discussions, see Oldshue, J. Y. Fluid Mixing Technology; McGraw-Hill: New York, 1983; Levenspiel, O. Chemical Reaction Engineering, 3rd ed.; John Wiley & Sons: New York, 1999; Denbigh, K. G.; Turner, J. C. R. Chemical Reactor Theory, 3rd ed.; Cambridge University Press: Cambridge, 1984; Walas, S. M. Chemical Reactors. In Perry's Chemical Engineer's Handbook, 7th ed.; Perry, R. H., Green, D. W., Maloney, J. O., Eds.; McGraw-Hill: New York, 1997; pp 23-61; Scaleup of Chemical Processes. Conversion from Laboratory Scale Tests to Successful Commercial Size Design; Bisio, A., Kabel, R. L., Eds.; Wiley: New York, 1985.
17. For detailed discussions, see Oldshue, J. Y. Fluid Mixing Technology; McGraw-Hill: New York, 1983; Levenspiel, O. Chemical Reaction Engineering, 3rd ed.; John Wiley & Sons: New York, 1999; Denbigh, K. G.; Turner, J. C. R. Chemical Reactor Theory, 3rd ed.; Cambridge University Press: Cambridge, 1984; Walas, S. M. Chemical Reactors. In Perry's Chemical Engineer's Handbook, 7th ed.; Perry, R. H., Green, D. W., Maloney, J. O., Eds.; McGraw-Hill: New York, 1997; pp 23-61; Scaleup of Chemical Processes. Conversion from Laboratory Scale Tests to Successful Commercial Size Design; Bisio, A., Kabel, R. L., Eds.; Wiley: New York, 1985.
18. For detailed discussions, see Oldshue, J. Y. Fluid Mixing Technology; McGraw-Hill: New York, 1983; Levenspiel, O. Chemical Reaction Engineering, 3rd ed.; John Wiley & Sons: New York, 1999; Denbigh, K. G.; Turner, J. C. R. Chemical Reactor Theory, 3rd ed.; Cambridge University Press: Cambridge, 1984; Walas, S. M. Chemical Reactors. In Perry's Chemical Engineer's Handbook, 7th ed.; Perry, R. H., Green, D. W., Maloney, J. O., Eds.; McGraw-Hill: New York, 1997; pp 23-61; Scaleup of Chemical Processes. Conversion from Laboratory Scale Tests to Successful Commercial Size Design; Bisio, A., Kabel, R. L., Eds.; Wiley: New York, 1985.
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