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Volumn 41, Issue 9, 2013, Pages 5104-5114

A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ALANINE; CYTOSINE; DNA POLYMERASE; DNA POLYMERASE IV; ESCHERICHIA COLI PROTEIN; NUCLEOTIDE; NUCLEOTIDE TRIPHOSPHATE; SERINE; UNCLASSIFIED DRUG;

EID: 84877310722     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt146     Document Type: Article
Times cited : (33)

References (59)
  • 1
    • 33644857994 scopus 로고    scopus 로고
    • Environmental tuning of mutation rates
    • Saint-Ruf, C. and Matic, I. (2006) Environmental tuning of mutation rates. Environ. Microbiol., 8, 193-199.
    • (2006) Environ. Microbiol. , vol.8 , pp. 193-199
    • Saint-Ruf, C.1    Matic, I.2
  • 3
    • 35148899681 scopus 로고    scopus 로고
    • Stress-induced mutagenesis in bacteria
    • Foster, P.L. (2007) Stress-induced mutagenesis in bacteria. Crit. Rev. Biochem. Mol. Biol., 42, 373-397.
    • (2007) Crit. Rev. Biochem. Mol. Biol. , vol.42 , pp. 373-397
    • Foster, P.L.1
  • 5
    • 2542440567 scopus 로고    scopus 로고
    • Error-prone replication for better or worse
    • Tippin, B., Pham, P. and Goodman, M.F. (2004) Error-prone replication for better or worse. Trends Microbiol., 12, 288-295.
    • (2004) Trends Microbiol. , vol.12 , pp. 288-295
    • Tippin, B.1    Pham, P.2    Goodman, M.F.3
  • 6
    • 0035905817 scopus 로고    scopus 로고
    • A model for SOS-lesion-targeted mutations in Escherichia coli
    • Pham, P., Bertram, J.G., O'Donnell, M., Woodgate, R. and Goodman, M.F. (2001) A model for SOS-lesion-targeted mutations in Escherichia coli. Nature, 409, 366-370.
    • (2001) Nature , vol.409 , pp. 366-370
    • Pham, P.1    Bertram, J.G.2    O'Donnell, M.3    Woodgate, R.4    Goodman, M.F.5
  • 7
    • 0037853272 scopus 로고    scopus 로고
    • Error-prone polymerase, DNA polymerase IV, is responsible for transient hypermutation during adaptive mutation in Escherichia coli
    • Tompkins, J.D., Nelson, J.L., Hazel, J.C., Leugers, S.L., Stumpf, J.D. and Foster, P.L. (2003) Error-prone polymerase, DNA polymerase IV, is responsible for transient hypermutation during adaptive mutation in Escherichia coli. J. Bacteriol., 185, 3469-3472.
    • (2003) J. Bacteriol. , vol.185 , pp. 3469-3472
    • Tompkins, J.D.1    Nelson, J.L.2    Hazel, J.C.3    Leugers, S.L.4    Stumpf, J.D.5    Foster, P.L.6
  • 8
    • 0031443646 scopus 로고    scopus 로고
    • Multiple pathways for SOS-induced mutagenesis in Escherichia coli: An overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA
    • Kim, S.R., Maenhaut-Michel, G., Yamada, M., Yamamoto, Y., Matsui, K., Sofuni, T., Nohmi, T. and Ohmori, H. (1997) Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA. Proc. Natl Acad. Sci. USA, 94, 13792-13797.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 13792-13797
    • Kim, S.R.1    Maenhaut-Michel, G.2    Yamada, M.3    Yamamoto, Y.4    Matsui, K.5    Sofuni, T.6    Nohmi, T.7    Ohmori, H.8
  • 9
    • 0022515733 scopus 로고
    • Role of RecA protein in untargeted UV mutagenesis of bacteriophage lambda: Evidence for the requirement for the dinB gene
    • Brotcorne-Lannoye, A. and Maenhaut-Michel, G. (1986) Role of RecA protein in untargeted UV mutagenesis of bacteriophage lambda: evidence for the requirement for the dinB gene. Proc. Natl Acad. Sci. USA, 83, 3904-3908.
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 3904-3908
    • Brotcorne-Lannoye, A.1    Maenhaut-Michel, G.2
  • 10
    • 24944477416 scopus 로고    scopus 로고
    • A switch from high-fidelity to error-prone DNA double-strand break repair underlies stress-induced mutation
    • Ponder, R.G., Fonville, N.C. and Rosenberg, S.M. (2005) A switch from high-fidelity to error-prone DNA double-strand break repair underlies stress-induced mutation. Mol. Cell, 19, 791-804.
    • (2005) Mol. Cell , vol.19 , pp. 791-804
    • Ponder, R.G.1    Fonville, N.C.2    Rosenberg, S.M.3
  • 11
    • 10044234196 scopus 로고    scopus 로고
    • Properties and functions of Escherichia coli: Pol IV and Pol v
    • Fuchs, R.P., Fujii, S. and Wagner, J. (2004) Properties and functions of Escherichia coli: Pol IV and Pol V. Adv. Protein Chem., 69, 229-264.
    • (2004) Adv. Protein Chem. , vol.69 , pp. 229-264
    • Fuchs, R.P.1    Fujii, S.2    Wagner, J.3
  • 12
    • 79959567810 scopus 로고    scopus 로고
    • Escherichia coli y family DNA polymerases
    • Walsh, J.M., Hawver, L.A. and Beuning, P.J. (2012) Escherichia coli Y family DNA polymerases. Front Biosci., 17, 3164-3182.
    • (2012) Front Biosci. , vol.17 , pp. 3164-3182
    • Walsh, J.M.1    Hawver, L.A.2    Beuning, P.J.3
  • 13
    • 0037172966 scopus 로고    scopus 로고
    • SOS-induced DNA polymerases enhance long-term survival and evolutionary fitness
    • Yeiser, B., Pepper, E.D., Goodman, M.F. and Finkel, S.E. (2002) SOS-induced DNA polymerases enhance long-term survival and evolutionary fitness. Proc. Natl Acad. Sci. USA, 99, 8737-8741.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 8737-8741
    • Yeiser, B.1    Pepper, E.D.2    Goodman, M.F.3    Finkel, S.E.4
  • 14
    • 0035265678 scopus 로고    scopus 로고
    • SOS mutator DNA polymerase IV functions in adaptive mutation and not adaptive amplification
    • McKenzie, G.J., Lee, P.L., Lombardo, M.J., Hastings, P.J. and Rosenberg, S.M. (2001) SOS mutator DNA polymerase IV functions in adaptive mutation and not adaptive amplification. Mol. Cell, 7, 571-579.
    • (2001) Mol. Cell , vol.7 , pp. 571-579
    • McKenzie, G.J.1    Lee, P.L.2    Lombardo, M.J.3    Hastings, P.J.4    Rosenberg, S.M.5
  • 15
    • 0034462969 scopus 로고    scopus 로고
    • Role of the dinB gene product in spontaneous mutation in Escherichia coli with an impaired replicative polymerase
    • Strauss, B.S., Roberts, R., Francis, L. and Pouryazdanparast, P. (2000) Role of the dinB gene product in spontaneous mutation in Escherichia coli with an impaired replicative polymerase. J. Bacteriol., 182, 6742-6750.
    • (2000) J. Bacteriol. , vol.182 , pp. 6742-6750
    • Strauss, B.S.1    Roberts, R.2    Francis, L.3    Pouryazdanparast, P.4
  • 16
    • 33750344433 scopus 로고    scopus 로고
    • Environmental stress and lesion-bypass DNA polymerases
    • Nohmi, T. (2006) Environmental stress and lesion-bypass DNA polymerases. Annu. Rev. Microbiol., 60, 231-253.
    • (2006) Annu. Rev. Microbiol. , vol.60 , pp. 231-253
    • Nohmi, T.1
  • 17
    • 0142062024 scopus 로고    scopus 로고
    • Error-prone DNA polymerase IV is controlled by the stress-response sigma factor, RpoS, in Escherichia coli
    • Layton, J.C. and Foster, P.L. (2003) Error-prone DNA polymerase IV is controlled by the stress-response sigma factor, RpoS, in Escherichia coli. Mol. Microbiol., 50, 549-561.
    • (2003) Mol. Microbiol. , vol.50 , pp. 549-561
    • Layton, J.C.1    Foster, P.L.2
  • 18
    • 67849086820 scopus 로고    scopus 로고
    • DinB upregulation is the sole role of the SOS response in stress-induced mutagenesis in Escherichia coli
    • Galhardo, R.S., Do, R., Yamada, M., Friedberg, E.C., Hastings, P.J., Nohmi, T. and Rosenberg, S.M. (2009) DinB upregulation is the sole role of the SOS response in stress-induced mutagenesis in Escherichia coli. Genetics, 182, 55-68.
    • (2009) Genetics , vol.182 , pp. 55-68
    • Galhardo, R.S.1    Do, R.2    Yamada, M.3    Friedberg, E.C.4    Hastings, P.J.5    Nohmi, T.6    Rosenberg, S.M.7
  • 19
    • 14544281666 scopus 로고    scopus 로고
    • SOS-independent induction of dinB transcription by beta-lactam-mediated inhibition of cell wall synthesis in Escherichia coli
    • Perez-Capilla, T., Baquero, M.R., Gomez-Gomez, J.M., Ionel, A., Martin, S. and Blazquez, J. (2005) SOS-independent induction of dinB transcription by beta-lactam-mediated inhibition of cell wall synthesis in Escherichia coli. J. Bacteriol., 187, 1515-1518.
    • (2005) J. Bacteriol. , vol.187 , pp. 1515-1518
    • Perez-Capilla, T.1    Baquero, M.R.2    Gomez-Gomez, J.M.3    Ionel, A.4    Martin, S.5    Blazquez, J.6
  • 21
    • 0033880695 scopus 로고    scopus 로고
    • Escherichia coli DNA polymerase IV mutator activity: Genetic requirements and mutational specificity
    • Wagner, J. and Nohmi, T. (2000) Escherichia coli DNA polymerase IV mutator activity: genetic requirements and mutational specificity. J. Bacteriol., 182, 4587-4595.
    • (2000) J. Bacteriol. , vol.182 , pp. 4587-4595
    • Wagner, J.1    Nohmi, T.2
  • 22
    • 0037072865 scopus 로고    scopus 로고
    • Fidelity of Escherichia coli DNA polymerase IV. Preferential generation of small deletion mutations by dNTP-stabilized misalignment
    • Kobayashi, S., Valentine, M.R., Pham, P., O'Donnell, M. and Goodman, M.F. (2002) Fidelity of Escherichia coli DNA polymerase IV. Preferential generation of small deletion mutations by dNTP-stabilized misalignment. J. Biol. Chem., 277, 34198-34207.
    • (2002) J. Biol. Chem. , vol.277 , pp. 34198-34207
    • Kobayashi, S.1    Valentine, M.R.2    Pham, P.3    O'Donnell, M.4    Goodman, M.F.5
  • 23
    • 34247140642 scopus 로고    scopus 로고
    • Escherichia coli DNA polymerase IV contributes to spontaneous mutagenesis at coding sequences but not microsatellite alleles
    • Jacob, K.D. and Eckert, K.A. (2007) Escherichia coli DNA polymerase IV contributes to spontaneous mutagenesis at coding sequences but not microsatellite alleles. Mutat. Res., 619, 93-103.
    • (2007) Mutat. Res. , vol.619 , pp. 93-103
    • Jacob, K.D.1    Eckert, K.A.2
  • 24
    • 70349142721 scopus 로고    scopus 로고
    • Stress-induced beta-lactam antibiotic resistance mutation and sequences of stationary-phase mutations in the Escherichia coli chromosome
    • Petrosino, J.F., Galhardo, R.S., Morales, L.D. and Rosenberg, S.M. (2009) Stress-induced beta-lactam antibiotic resistance mutation and sequences of stationary-phase mutations in the Escherichia coli chromosome. J. Bacteriol., 191, 5881-5889.
    • (2009) J. Bacteriol. , vol.191 , pp. 5881-5889
    • Petrosino, J.F.1    Galhardo, R.S.2    Morales, L.D.3    Rosenberg, S.M.4
  • 25
    • 33846054066 scopus 로고    scopus 로고
    • Bacterial stationary-state mutagenesis and mammalian tumorigenesis as stress-induced cellular adaptations and the role of epigenetics
    • Karpinets, T., Greenwood, D., Pogribny, I. and Samatova, N. (2006) Bacterial stationary-state mutagenesis and mammalian tumorigenesis as stress-induced cellular adaptations and the role of epigenetics. Curr. Genomics, 7, 481-496.
    • (2006) Curr. Genomics , vol.7 , pp. 481-496
    • Karpinets, T.1    Greenwood, D.2    Pogribny, I.3    Samatova, N.4
  • 26
    • 29944445616 scopus 로고    scopus 로고
    • Induction and inhibition of ciprofloxacin resistance-conferring mutations in hypermutator bacteria
    • Cirz, R.T. and Romesberg, F.E. (2006) Induction and inhibition of ciprofloxacin resistance-conferring mutations in hypermutator bacteria. Antimicrob. Agents Chemother., 50, 220-225.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 220-225
    • Cirz, R.T.1    Romesberg, F.E.2
  • 28
    • 37549039510 scopus 로고    scopus 로고
    • A short history of SHELX
    • Sheldrick, G.M. (2008) A short history of SHELX. Acta Crystallogr. A, 64, 112-122.
    • (2008) Acta Crystallogr. A , vol.64 , pp. 112-122
    • Sheldrick, G.M.1
  • 29
    • 84889120137 scopus 로고
    • Improved methods for building protein models in electron density maps and the location of errors in these models
    • Jones, T.A., Zou, J.Y., Cowan, S.W. and Kjeldgaard, M. (1991) Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A, 47Pt 2), 110-119.
    • (1991) Acta Crystallogr. A , vol.47 , Issue.PART 2 , pp. 110-119
    • Jones, T.A.1    Zou, J.Y.2    Cowan, S.W.3    Kjeldgaard, M.4
  • 30
    • 84864869349 scopus 로고    scopus 로고
    • The PAD region in the mycobacterial DinB homologue MsPol IV exhibits positional heterogeneity
    • Sharma, A., Subramanian, V. and Nair, D.T. (2012) The PAD region in the mycobacterial DinB homologue MsPol IV exhibits positional heterogeneity. Acta Crystallogr. D Biol. Crystallogr., D68, 960-967.
    • (2012) Acta Crystallogr. D Biol. Crystallogr. D , vol.68 , pp. 960-967
    • Sharma, A.1    Subramanian, V.2    Nair, D.T.3
  • 31
    • 0242389787 scopus 로고    scopus 로고
    • Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the beta-clamp
    • Bunting, K.A., Roe, S.M. and Pearl, L.H. (2003) Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the beta-clamp. EMBO J., 22, 5883-5892.
    • (2003) EMBO J. , vol.22 , pp. 5883-5892
    • Bunting, K.A.1    Roe, S.M.2    Pearl, L.H.3
  • 34
    • 84864871068 scopus 로고    scopus 로고
    • MsDpo4-a DinB homolog from mycobacterium smegmatis-Is an error-prone DNA polymerase that can promote G:T and T:G mismatches
    • Sharma, A. and Nair, D.T. (2012) MsDpo4-a DinB homolog from mycobacterium smegmatis-Is an error-prone DNA polymerase that can promote G:T and T:G mismatches. J. Nucleic Acids, 2012, 285481.
    • (2012) J. Nucleic Acids , vol.2012 , pp. 285481
    • Sharma, A.1    Nair, D.T.2
  • 35
    • 0033581011 scopus 로고    scopus 로고
    • DNA polymerases: Structural diversity and common mechanisms
    • Steitz, T.A. (1999) DNA polymerases: structural diversity and common mechanisms. J. Biol. Chem., 274, 17395-17398.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17395-17398
    • Steitz, T.A.1
  • 38
    • 0345269987 scopus 로고    scopus 로고
    • Deoxynucleotide triphosphate binding mode conserved in y family DNA polymerases
    • Johnson, R.E., Trincao, J., Aggarwal, A.K., Prakash, S. and Prakash, L. (2003) Deoxynucleotide triphosphate binding mode conserved in Y family DNA polymerases. Mol. Cell Biol., 23, 3008-3012.
    • (2003) Mol. Cell Biol. , vol.23 , pp. 3008-3012
    • Johnson, R.E.1    Trincao, J.2    Aggarwal, A.K.3    Prakash, S.4    Prakash, L.5
  • 40
    • 3142674288 scopus 로고    scopus 로고
    • Replication by human DNA polymerase-iota occurs by hoogsteen base-pairing
    • Nair, D.T., Johnson, R.E., Prakash, S., Prakash, L. and Aggarwal, A.K. (2004) Replication by human DNA polymerase-iota occurs by hoogsteen base-pairing. Nature, 430, 377-380.
    • (2004) Nature , vol.430 , pp. 377-380
    • Nair, D.T.1    Johnson, R.E.2    Prakash, S.3    Prakash, L.4    Aggarwal, A.K.5
  • 41
    • 77953921670 scopus 로고    scopus 로고
    • Structural basis for the suppression of skin cancers by DNA polymerase eta
    • Silverstein, T.D., Johnson, R.E., Jain, R., Prakash, L., Prakash, S. and Aggarwal, A.K. (2010) Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature, 465, 1039-1043.
    • (2010) Nature , vol.465 , pp. 1039-1043
    • Silverstein, T.D.1    Johnson, R.E.2    Jain, R.3    Prakash, L.4    Prakash, S.5    Aggarwal, A.K.6
  • 42
    • 25844440534 scopus 로고    scopus 로고
    • Rev1 employs a novel mechanism of DNA synthesis using a protein template
    • Nair, D.T., Johnson, R.E., Prakash, L., Prakash, S. and Aggarwal, A.K. (2005) Rev1 employs a novel mechanism of DNA synthesis using a protein template. Science, 309, 2219-2222.
    • (2005) Science , vol.309 , pp. 2219-2222
    • Nair, D.T.1    Johnson, R.E.2    Prakash, L.3    Prakash, S.4    Aggarwal, A.K.5
  • 44
    • 0035812849 scopus 로고    scopus 로고
    • Crystal structure of a Y-family DNA polymerase in action: A mechanism for error-prone and lesion-bypass replication
    • Ling, H., Boudsocq, F., Woodgate, R. and Yang, W. (2001) Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication. Cell, 107, 91-102.
    • (2001) Cell , vol.107 , pp. 91-102
    • Ling, H.1    Boudsocq, F.2    Woodgate, R.3    Yang, W.4
  • 45
    • 40849124424 scopus 로고    scopus 로고
    • Structural insights into the generation of single-base deletions by the y family DNA polymerase dbh
    • Wilson, R.C. and Pata, J.D. (2008) Structural insights into the generation of single-base deletions by the Y family DNA polymerase dbh. Mol. Cell, 29, 767-779.
    • (2008) Mol. Cell , vol.29 , pp. 767-779
    • Wilson, R.C.1    Pata, J.D.2
  • 47
    • 4644258145 scopus 로고    scopus 로고
    • Structural insights into DNA polymerase beta deterrents for misincorporation support an induced-fit mechanism for fidelity
    • Krahn, J.M., Beard, W.A. and Wilson, S.H. (2004) Structural insights into DNA polymerase beta deterrents for misincorporation support an induced-fit mechanism for fidelity. Structure, 12, 1823-1832.
    • (2004) Structure , vol.12 , pp. 1823-1832
    • Krahn, J.M.1    Beard, W.A.2    Wilson, S.H.3
  • 48
    • 27144542782 scopus 로고    scopus 로고
    • Fidelity of Dpo4: Effect of metal ions, nucleotide selection and pyrophosphorolysis
    • Vaisman, A., Ling, H., Woodgate, R. and Yang, W. (2005) Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis. EMBO J., 24, 2957-2967.
    • (2005) EMBO J. , vol.24 , pp. 2957-2967
    • Vaisman, A.1    Ling, H.2    Woodgate, R.3    Yang, W.4
  • 51
    • 2342419732 scopus 로고    scopus 로고
    • DNA replication fidelity
    • Kunkel, T.A. (2004) DNA replication fidelity. J. Biol. Chem., 279, 16895-16898.
    • (2004) J. Biol. Chem. , vol.279 , pp. 16895-16898
    • Kunkel, T.A.1
  • 52
    • 67651218926 scopus 로고    scopus 로고
    • RB69 DNA polymerase mutants with expanded nascent base-pair-binding pockets are highly efficient but have reduced base selectivity
    • Zhang, H., Beckman, J., Wang, J. and Konigsberg, W. (2009) RB69 DNA polymerase mutants with expanded nascent base-pair-binding pockets are highly efficient but have reduced base selectivity. Biochemistry, 48, 6940-6950.
    • (2009) Biochemistry , vol.48 , pp. 6940-6950
    • Zhang, H.1    Beckman, J.2    Wang, J.3    Konigsberg, W.4
  • 53
    • 33144478306 scopus 로고    scopus 로고
    • The L561A substitution in the nascent base-pair binding pocket of RB69 DNA polymerase reduces base discrimination
    • Zhang, H., Rhee, C., Bebenek, A., Drake, J.W., Wang, J. and Konigsberg, W. (2006) The L561A substitution in the nascent base-pair binding pocket of RB69 DNA polymerase reduces base discrimination. Biochemistry, 45, 2211-2220.
    • (2006) Biochemistry , vol.45 , pp. 2211-2220
    • Zhang, H.1    Rhee, C.2    Bebenek, A.3    Drake, J.W.4    Wang, J.5    Konigsberg, W.6
  • 54
    • 33645216188 scopus 로고    scopus 로고
    • Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta
    • Venkatesan, R.N., Hsu, J.J., Lawrence, N.A., Preston, B.D. and Loeb, L.A. (2006) Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta. J. Biol. Chem., 281, 4486-4494.
    • (2006) J. Biol. Chem. , vol.281 , pp. 4486-4494
    • Venkatesan, R.N.1    Hsu, J.J.2    Lawrence, N.A.3    Preston, B.D.4    Loeb, L.A.5
  • 55
    • 34047260752 scopus 로고    scopus 로고
    • Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta
    • Nick McElhinny, S.A., Stith, C.M., Burgers, P.M. and Kunkel, T.A. (2007) Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta. J. Biol. Chem., 282, 2324-2332.
    • (2007) J. Biol. Chem. , vol.282 , pp. 2324-2332
    • Nick McElhinny, S.A.1    Stith, C.M.2    Burgers, P.M.3    Kunkel, T.A.4
  • 56
    • 0042388279 scopus 로고    scopus 로고
    • Mutations in DNA polymerase gamma cause error prone DNA synthesis in human mitochondrial disorders
    • Copeland, W.C., Ponamarev, M.V., Nguyen, D., Kunkel, T.A. and Longley, M.J. (2003) Mutations in DNA polymerase gamma cause error prone DNA synthesis in human mitochondrial disorders. Acta Biochim. Pol., 50, 155-167.
    • (2003) Acta Biochim. Pol. , vol.50 , pp. 155-167
    • Copeland, W.C.1    Ponamarev, M.V.2    Nguyen, D.3    Kunkel, T.A.4    Longley, M.J.5
  • 57
    • 0037102491 scopus 로고    scopus 로고
    • The non-Watson-Crick base pairs and their associated isostericity matrices
    • Leontis, N.B., Stombaugh, J. and Westhof, E. (2002) The non-Watson-Crick base pairs and their associated isostericity matrices. Nucleic Acids Res., 30, 3497-3531.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 3497-3531
    • Leontis, N.B.1    Stombaugh, J.2    Westhof, E.3
  • 59
    • 55249099793 scopus 로고    scopus 로고
    • Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli
    • Gonzalez, C., Hadany, L., Ponder, R.G., Price, M., Hastings, P.J. and Rosenberg, S.M. (2008) Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli. PLoS Genet., 4, e1000208.
    • (2008) PLoS Genet. , vol.4
    • Gonzalez, C.1    Hadany, L.2    Ponder, R.G.3    Price, M.4    Hastings, P.J.5    Rosenberg, S.M.6


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