SOS mutator DNA polymerase IV functions in adaptive mutation and not adaptive amplification

Molecular Cell

Volumn 7, Issue 3, 2001, Pages 571-579

  McKenzie, Gregory J ^a   Lee, Peter L ^a   Lombardo, Mary Jane ^a   Hastings, P J ^a   Rosenberg, Susan M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DINB ENZYME; DNA POLYMERASE; DNA POLYMERASE IV; POL PROTEIN; PROTEIN POL III; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; ESCHERICHIA COLI; GENE AMPLIFICATION; GENE MUTATION; LACTOSE OPERON; MUTATION RATE; NONHUMAN; OXIDATIVE STRESS; POINT MUTATION; PROTEIN ANALYSIS; STRESS; ULTRAVIOLET RADIATION;

ESCHERICHIA COLI;

EID: 0035265678     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00204-0     Document Type: Article

References (65)

1. Role of RecA protein in untargeted UV mutagenesis of bacteriophage lambda: Evidence for the requirement for the dinB gene
2. Evidence that stationary-phase hypermutation in the Escherichia coli chromosome is promoted by recombination
3. The contribution of transiently hypermutable cells to mutation in stationary phase
4. The contribution of bacterial hypermutators to mutation in stationary phase
5. Adaptive reversion of a frameshift mutation in Escherichia coli
6. Comparative gene expression profiles following UV exposure in wild-type and SOS-deficient Escherichia coli
7. Shared themes of antigenic variation and virulence in bacterial, protozoal, and fungal infections
8. Escherichia coli xth mutants are hypersensitive to hydrogen peroxide
9. Evolutionary implications of the frequent horizontal transfer of mismatch repair genes
10. SOS functions, cancer and inducible evolution
11. Mutants of Escherichia coli with increased fidelity of DNA replication
12. Nonadaptive mutations occur in the F′ episome during adaptive mutation conditions in Escherichia coli
13. Mechanisms of stationary phase mutation: A decade of adaptive mutation
14. Adaptive reversion of a frameshift mutation in Escherichia coli by simple base deletions in homopolymeric runs
15. Proofreading-defective DNA polymerase II increases adaptive mutation in Escherichia coli
16. Two enzymes, both of which process recombination intermediates, have opposite effects on adaptive mutation in Escherichia coli
17. The many faces of DNA polymerases: Strategies for mutagenesis and for mutational avoidance
18. Some features of the mutability of bacteria during nonlethal selection
19. Toxin-antitoxin systems homologous with relBE of Escherichia coli plasmid P307 are ubiquitous in prokaryotes
20. Recombination in adaptive mutation
21. Opposing roles of the Holliday junction processing systems of Escherichia coli in recombination-dependent adaptive mutation
22. A direct role for DNA polymerase III in adaptive reversion of a frameshift mutation in Escherichia coli
23. Mismatch repair protein MutL becomes limiting during stationary-phase mutation
24. Mismatch repair is diminished during stationary-phase mutation
25. Adaptive amplification: An inducible chromosomal instability mechanism
26. A role for REV3 in mutagenesis during double-strand break repair in Saccharomyces cerevisiae
27. DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli
28. Multiple pathways for SOS-induced mutagenesis in Escherichia coli: An overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA
29. Mutant selections linking physiology, inhibitors, and genotypes
30. The distribution of the numbers of mutants in bacterial populations
31. High mutation frequencies among Escherichia coli and Salmonella pathogens
32. Autodigestion and RecA-dependent cleavage of Ind- mutant LexA proteins
33. Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: Application to open reading frame characterization
34. Adaptive mutation sequences reproduced by mismatch repair deficiency
35. Highly variable mutation rates in commensal and pathogenic Escherichia coli
36. Recombination-dependent mutation in Escherichia coli occurs in stationary phase
37. The SOS response regulates adaptive mutation
38. Mismatch repair in replication fidelity, genetic recombination, and cancer biology
39. Dominant mutations (lex) in Escherichia coli K-12 which affect radiation sensitivity and frequency of ultraviolet light-induced mutations
40. All three SOS-inducible DNA polymerases (pol II, pol IV, and pol V) are involved in induced mutagenesis
41. High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection
42. Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491
43. SOS repair hypothesis: Phenomenology of an inducible DNA repair which is accompanied by mutagenesis
44. Frameshift mutation: Determinants of specificity
45. The role of transient hypermutators in adaptive mutation in Escherichia coli
46. Determining mutation rates in bacterial populations
47. Mutation for survival
48. Evolution at will: Adaptive mutation
49. Adaptive mutation by deletions in small mononucleotide repeats
50. Transient and heritable mutators in adaptive evolution in the lab and in nature
51. Repeat-associated phase variable genes in the complete genome sequence of Neisseria meningitidis strain MC58
52. The extreme mutator effect of Escherichia coli mutD5 results from saturation of mismatch repair by excessive DNA replication errors
53. Role of the dinB gene product in spontaneous mutation in Escherichia coli with an impaired replicative polymerase
54. Frameshift mutations and the genetic code
55. Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis
56. Complete genome sequence of Neisseria meningitidis serogroup B strain MC58
57. Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation
58. Measuring spontaneous mutation rates in yeast
59. Escherichia coli DNA polymerase IV mutator activity: Genetic requirements and mutational specificity
60. The dinB gene encodes a novel E. coli DNA polymerase, DNA pol IV, involved in mutagenesis
61. The β clamp targets DNA polymerase IV to DNA and strongly increases its processivity
62. The SOS response of Escherichia coli