FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress

Nature Communications

Volumn 4, Issue , 2013, Pages

  Fugger, Kasper ^a   Chu, Wai Kit ^b,c   Haahr, Peter ^a   Nedergaard Kousholt, Arne ^a   Beck, Halfdan ^a   Payne, Miranda J ^b   Hanada, Katsuhiro ^b   Hickson, Ian D ^b,c   Sørensen, Claus Storgaard ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; DOXORUBICIN; ENDONUCLEASE; FBH1 HELICASE; HELICASE; HYDROXYUREA; MUS81 PROTEIN; PROTEIN P53; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; DOXYCYCLINE; F BOX PROTEIN; FBXO18 PROTEIN, HUMAN; FBXO18 PROTEIN, MOUSE; MUS81 PROTEIN, HUMAN; MUS81 PROTEIN, MOUSE; SMALL INTERFERING RNA;

ALLELE; CELL ORGANELLE; DNA; ENZYME ACTIVITY; INHIBITION; INHIBITOR; RODENT;

ALLELE; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DNA DAMAGE CHECKPOINT; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE DISRUPTION; HUMAN; HUMAN CELL; MARKER GENE; STRESS; ANIMAL; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MOUSE; PHYSIOLOGICAL STRESS; SIGNAL TRANSDUCTION; SOUTHERN BLOTTING; TUMOR CELL LINE;

ALLELES; ANIMALS; BLOTTING, SOUTHERN; CELL DEATH; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; DNA HELICASES; DNA REPLICATION; DNA-BINDING PROTEINS; DOXYCYCLINE; EMBRYONIC STEM CELLS; ENDONUCLEASES; F-BOX PROTEINS; HUMANS; MICE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL;

MLCS; MLOWN;

EID: 84877155835     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms2395     Document Type: Article

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