Mouse liver-specific CD8+ T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes

Journal of Autoimmunity

Volumn 42, Issue , 2013, Pages 19-28

  Chabot, Sylvie ^a,b   Fakhfakh, Amin ^a   Béland, Kathie ^a   Lamarre, Alain ^c   Oldstone, Michael B A ^d   Alvarez, Fernando ^a,b   Djilali Saiah, Idriss ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c INRS INSTITUT ARMAND FRAPPIER   (Canada)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Autoimmune hepatitis; Autoreactive CD8+ T cells; Peripheral tolerance mechanisms; Transgenic mouse model

Indexed keywords

AUTOANTIGEN; LIVER ANTIGEN; NUCLEOPROTEIN;

ANIMAL CELL; ARTICLE; AUTOIMMUNE HEPATITIS; AUTOIMMUNITY; BIOACCUMULATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOREACTIVITY; LIVER CELL; LIVER INJURY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL; TARGET CELL; THYMOCYTE; UPREGULATION;

ANIMALS; ANTIGENS, VIRAL; APOPTOSIS; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; DISEASE MODELS, ANIMAL; FEMALE; HEPATITIS, AUTOIMMUNE; HEPATOCYTES; LIVER; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NUCLEOPROTEINS; ORGAN SPECIFICITY; TRANSGENES;

EID: 84877155663     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2012.10.002     Document Type: Article

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