메뉴 건너뛰기




Volumn 5, Issue , 2012, Pages 573-582

Effects of diet-induced obesity on protein expression in insulin signaling pathways of skelet al muscle in male Wistar rats

Author keywords

Diet induced obesity; Fenofibrate; Insulin signaling; Intramuscular lipids; Muscle

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR BETA; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C BETA; PROTEIN SHC; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84877143750     PISSN: None     EISSN: 11787074     Source Type: Journal    
DOI: 10.2147/IJGM.S31819     Document Type: Article
Times cited : (11)

References (45)
  • 1
    • 0023683874 scopus 로고
    • An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects
    • Dohm G, Tapscott E, Poruies W, et al. An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J Clin Invest. 1988;82:486-494.
    • (1988) J Clin Invest. , vol.82 , pp. 486-494
    • Dohm, G.1    Tapscott, E.2    Poruies, W.3
  • 2
    • 84897364648 scopus 로고    scopus 로고
    • The effects of diet-induced obesity on hepatocyte insulin signaling pathways and induction of non-alcoholic liver damage
    • Fatani S, Itua I, Clark P, Wong C, Naderali EK. The effects of diet-induced obesity on hepatocyte insulin signaling pathways and induction of non-alcoholic liver damage. Int J Gen Med. 2011;4:211-219.
    • (2011) Int J Gen Med. , vol.4 , pp. 211-219
    • Fatani, S.1    Itua, I.2    Clark, P.3    Wong, C.4    Naderali, E.K.5
  • 3
    • 0033536157 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance in humans
    • Shulman GI. Cellular mechanisms of insulin resistance in humans. Am J Cardiol. 1999;84:3J-10J.
    • (1999) Am J Cardiol. , vol.84
    • Shulman, G.I.1
  • 4
    • 0036092239 scopus 로고    scopus 로고
    • Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry JD. Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes. 2002;51:7-18.
    • (2002) Diabetes. , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 5
    • 0029862973 scopus 로고    scopus 로고
    • Hyperinsulinemia as an independent risk factor for ischemic heart disease
    • Despres JP, Lam Lamarche B, Mauriège P, et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med. 1996;334:952-958.
    • (1996) N Engl J Med. , vol.334 , pp. 952-958
    • Despres, J.P.1    Lam Lamarche, B.2    Mauriège, P.3
  • 6
    • 0036295566 scopus 로고    scopus 로고
    • Protein kinase C and lipid-induced insulin resistance in skelet al muscle
    • Schmitz-Peiffer C. Protein kinase C and lipid-induced insulin resistance in skelet al muscle. Ann N Y Acad Sci. 2002;967:146-157.
    • (2002) Ann N Y Acad Sci. , vol.967 , pp. 146-157
    • Schmitz-Peiffer, C.1
  • 8
    • 0030792250 scopus 로고    scopus 로고
    • Protein kinase C isoforms beta 1 and beta 2inhibit the tyrosine kinase activity of the insulin receptor
    • Bossenmaier B, Mosthaf L, Mischak H, Ullrich A, Haring H. Protein kinase C isoforms beta 1 and beta 2inhibit the tyrosine kinase activity of the insulin receptor. Diabetologia. 1997;40:863-866.
    • (1997) Diabetologia. , vol.40 , pp. 863-866
    • Bossenmaier, B.1    Mosthaf, L.2    Mischak, H.3    Ullrich, A.4    Haring, H.5
  • 9
    • 0033861608 scopus 로고    scopus 로고
    • Involvement of protein kinase C in human skelet al muscle insulin resistance and obesity
    • Itani SI, Zhou Q, Pories WJ, Macdonald KG, Dohm GL. Involvement of protein kinase C in human skelet al muscle insulin resistance and obesity. Diabetes. 2000;49:1353-1358.
    • (2000) Diabetes. , vol.49 , pp. 1353-1358
    • Itani, S.I.1    Zhou, Q.2    Pories, W.J.3    McDonald, K.G.4    Dohm, G.L.5
  • 10
    • 0029853098 scopus 로고    scopus 로고
    • Lipid mediators of insulin resistance: Ceramide signalling down-regulates GLUT4gene transcription in 3T3-L1 adipocytes
    • Long S, Pekala P. Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4gene transcription in 3T3-L1 adipocytes. Biochem J. 1996;319:179-184.
    • (1996) Biochem J. , vol.319 , pp. 179-184
    • Long, S.1    Pekala, P.2
  • 11
    • 0038532298 scopus 로고    scopus 로고
    • A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
    • Chavez JA, Knotts TA, Wang LP, et al. A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem. 2003;278:10297-10303.
    • (2003) J Biol Chem. , vol.278 , pp. 10297-10303
    • Chavez, J.A.1    Knotts, T.A.2    Wang, L.P.3
  • 12
    • 33745896155 scopus 로고    scopus 로고
    • Recent advances in the relationship between obesity, inflammation, and insulin resistance
    • Bastard J, Maachi M, Lagathu C, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006;17:4-12.
    • (2006) Eur Cytokine Netw. , vol.17 , pp. 4-12
    • Bastard, J.1    Maachi, M.2    Lagathu, C.3
  • 13
    • 0030784947 scopus 로고    scopus 로고
    • Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: Parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA
    • Oakes N, Bell K, Furler S, et al. Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA. Diabetes. 1997;46:2022-2028.
    • (1997) Diabetes. , vol.46 , pp. 2022-2028
    • Oakes, N.1    Bell, K.2    Furler, S.3
  • 14
    • 1542705365 scopus 로고    scopus 로고
    • Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance
    • Monzillo L, Hamdy O, Horton E, et al. Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obes Res. 2003;11:1048-1054.
    • (2003) Obes Res. , vol.11 , pp. 1048-1054
    • Monzillo, L.1    Hamdy, O.2    Horton, E.3
  • 15
    • 0035141142 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) alpha activation lowers muscle lipids and improves insulin sensitivity in high fate-fed rats: Comparison with PPAR-gamma activation
    • Ye JM, Doyle PJ, Iglesias MA, Watson DG, Cooney GJ, Kraegen EW. Peroxisome proliferator-activated receptor (PPAR) alpha activation lowers muscle lipids and improves insulin sensitivity in high fate-fed rats: comparison with PPAR-gamma activation. Diabetes. 2001;50: 411-417.
    • (2001) Diabetes. , vol.50 , pp. 411-417
    • Ye, J.M.1    Doyle, P.J.2    Iglesias, M.A.3    Watson, D.G.4    Cooney, G.J.5    Kraegen, E.W.6
  • 16
    • 18644365060 scopus 로고    scopus 로고
    • Fenofibrate lowers abdominal and skelet al adiposity and improves insulin sensitivity in OLETF rats
    • Lee HJ, Choi SS, Park MK, et al. Fenofibrate lowers abdominal and skelet al adiposity and improves insulin sensitivity in OLETF rats. Biochem Biophys Res Commun. 2002;296:293-299.
    • (2002) Biochem Biophys Res Commun. , vol.296 , pp. 293-299
    • Lee, H.J.1    Choi, S.S.2    Park, M.K.3
  • 19
    • 0034754994 scopus 로고    scopus 로고
    • Dietary obesity in the rat induces endothelial dysfunction without causing insulin resistance: A possible role for triacylglycerols
    • Naderali EK, Brown MJ, Pickavance LC, Wilding JP, Doyle PJ, Williams G. Dietary obesity in the rat induces endothelial dysfunction without causing insulin resistance: a possible role for triacylglycerols. Clin Sci (Lond). 2001;101:499-506.
    • (2001) Clin Sci (Lond). , vol.101 , pp. 499-506
    • Naderali, E.K.1    Brown, M.J.2    Pickavance, L.C.3    Wilding, J.P.4    Doyle, P.J.5    Williams, G.6
  • 20
    • 33746983981 scopus 로고    scopus 로고
    • Specific protein kinase C isoforms as transducers and modulators of insulin signaling
    • Sampson SR, Cooper DR. Specific protein kinase C isoforms as transducers and modulators of insulin signaling. Mol Genet Metab. 2006;89:32-47.
    • (2006) Mol Genet Metab. , vol.89 , pp. 32-47
    • Sampson, S.R.1    Cooper, D.R.2
  • 21
    • 84868103777 scopus 로고    scopus 로고
    • Is there a metabolic program in the skelet al muscle of obese individuals?
    • Houmard J, Pories W, Dohm G. Is there a metabolic program in the skelet al muscle of obese individuals? J Obes. 2011;2011:250496.
    • (2011) J Obes. , vol.2011 , pp. 250496
    • Houmard, J.1    Pories, W.2    Dohm, G.3
  • 23
    • 71549149354 scopus 로고    scopus 로고
    • Role of fatty acid uptake and fatty acid [beta]-oxidation in mediating insulin resistance in heart and skelet al muscle
    • Zhang L, Keung W, Samokhvalov V, Wang W, Lopaschuk GD. Role of fatty acid uptake and fatty acid [beta]-oxidation in mediating insulin resistance in heart and skelet al muscle. Biochim Biophys Acta. 2010;1801:1-22.
    • (2010) Biochim Biophys Acta. , vol.1801 , pp. 1-22
    • Zhang, L.1    Keung, W.2    Samokhvalov, V.3    Wang, W.4    Lopaschuk, G.D.5
  • 24
    • 41349101561 scopus 로고    scopus 로고
    • Effects of fenofibrate on gene expression of carnitine palmitoyltransferase 1in liver and skelet al muscle and its influence on insulin sensitivity
    • Chinese
    • Bai X, Li H, Yang W, et al. Effects of fenofibrate on gene expression of carnitine palmitoyltransferase 1in liver and skelet al muscle and its influence on insulin sensitivity. Zhonghua Yi Xue Za Zhi. 2008;88:268-270. Chinese.
    • (2008) Zhonghua Yi Xue Za Zhi. , vol.88 , pp. 268-270
    • Bai, X.1    Li, H.2    Yang, W.3
  • 25
    • 79953667930 scopus 로고    scopus 로고
    • Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain
    • Selivanov VA, Votyakova TV, Pivtoraiko VN, et al. Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain. PLoS Comput Biol. 2011;7:e1001115.
    • (2011) PLoS Comput Biol. , vol.7
    • Selivanov, V.A.1    Votyakova, T.V.2    Pivtoraiko, V.N.3
  • 26
    • 33645452703 scopus 로고    scopus 로고
    • Chondrocyte cell death mediated by reactive oxygen species-dependent activation of PKC-betaI
    • Del Carlo M, Loeser RF. Chondrocyte cell death mediated by reactive oxygen species-dependent activation of PKC-betaI. Am J Physiol Cell Physiol. 2006;290:C802-C811.
    • (2006) Am J Physiol Cell Physiol. , vol.290
    • Del Carlo, M.1    Loeser, R.F.2
  • 28
    • 0036943641 scopus 로고    scopus 로고
    • Cytotoxic effect of peroxisome proliferator fenofibrate on human HepG2 hepatoma cell line and relevant mechanisms
    • Jiao HL, Zhao BL. Cytotoxic effect of peroxisome proliferator fenofibrate on human HepG2 hepatoma cell line and relevant mechanisms. Toxicol Appl Pharm. 2002;185:172-179.
    • (2002) Toxicol Appl Pharm. , vol.185 , pp. 172-179
    • Jiao, H.L.1    Zhao, B.L.2
  • 29
    • 0142138609 scopus 로고    scopus 로고
    • Protective effects of green tea polyphenols on human HepG2cells against oxidative damage of fenofibrate
    • Jiao HL, Ye P, Zhao BL. Protective effects of green tea polyphenols on human HepG2cells against oxidative damage of fenofibrate. Free Radic Biol Med. 2003;35:1121-1128.
    • (2003) Free Radic Biol Med. , vol.35 , pp. 1121-1128
    • Jiao, H.L.1    Ye, P.2    Zhao, B.L.3
  • 30
    • 0042093781 scopus 로고    scopus 로고
    • Insulin-stimulated protein kinase C activity is reduced in skelet al muscle of humans with obesity and type 2 diabetes
    • Kim YB, Kotani K, Ciaraldi TP, Henry RR, Kahn BB. Insulin-stimulated protein kinase C activity is reduced in skelet al muscle of humans with obesity and type 2 diabetes. Diabetes. 2003;52:1935-1942.
    • (2003) Diabetes. , vol.52 , pp. 1935-1942
    • Kim, Y.B.1    Kotani, K.2    Ciaraldi, T.P.3    Henry, R.R.4    Kahn, B.B.5
  • 31
    • 27144450970 scopus 로고    scopus 로고
    • Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): Actions and defects in obesity and type II diabetes
    • Farese RV, Sajan MP, Standaert ML. Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes. Exp Biol Med. 2005;230:593-605.
    • (2005) Exp Biol Med. , vol.230 , pp. 593-605
    • Farese, R.V.1    Sajan, M.P.2    Standaert, M.L.3
  • 32
    • 72049128291 scopus 로고    scopus 로고
    • Skelet al muscle insulin resistance: The interplay of local lipid excess and mitochondrial dysfunction
    • Chow L, From A, Seaquist E. Skelet al muscle insulin resistance: the interplay of local lipid excess and mitochondrial dysfunction. Metabolism. 2010;59:70-85.
    • (2010) Metabolism. , vol.59 , pp. 70-85
    • Chow, L.1    From, A.2    Seaquist, E.3
  • 33
    • 0036814583 scopus 로고    scopus 로고
    • Experimental approaches to study PPAR gamma agonists as antidiabetic drugs
    • Vazquez M, Silvestre J, Prous J. Experimental approaches to study PPAR gamma agonists as antidiabetic drugs. Methods Find Exp Clin Pharmacol. 2002;24:515-523.
    • (2002) Methods Find Exp Clin Pharmacol. , vol.24 , pp. 515-523
    • Vazquez, M.1    Silvestre, J.2    Prous, J.3
  • 34
    • 34247383057 scopus 로고    scopus 로고
    • Molecular mechanism of insulin resistance
    • Bhattacharya S, Dey D, Roy S. Molecular mechanism of insulin resistance. J Biosci. 2007;32:405-413.
    • (2007) J Biosci. , vol.32 , pp. 405-413
    • Bhattacharya, S.1    Dey, D.2    Roy, S.3
  • 35
    • 80052678652 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance in type 2 diabetes mellitus
    • Saini V. Molecular mechanisms of insulin resistance in type 2 diabetes mellitus. World J Diabetes. 2010;1:68-75.
    • (2010) World J Diabetes. , vol.1 , pp. 68-75
    • Saini, V.1
  • 36
    • 1442348156 scopus 로고    scopus 로고
    • Human placental growth hormone increases expression of the P85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skelet al muscle
    • Barbour LA, Shao J, Qiao L, et al. Human placental growth hormone increases expression of the P85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skelet al muscle. Endocrinology. 2004;145:1144-1150.
    • (2004) Endocrinology. , vol.145 , pp. 1144-1150
    • Barbour, L.A.1    Shao, J.2    Qiao, L.3
  • 37
    • 23644448924 scopus 로고    scopus 로고
    • Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skelet al muscle
    • Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM. Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skelet al muscle. Diabetes. 2005;54:2351-2359.
    • (2005) Diabetes. , vol.54 , pp. 2351-2359
    • Bandyopadhyay, G.K.1    Yu, J.G.2    Ofrecio, J.3    Olefsky, J.M.4
  • 38
    • 0032698470 scopus 로고    scopus 로고
    • Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
    • Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest. 1999;104:733-741.
    • (1999) J Clin Invest. , vol.104 , pp. 733-741
    • Kim, Y.B.1    Nikoulina, S.E.2    Ciaraldi, T.P.3    Henry, R.R.4    Kahn, B.B.5
  • 39
    • 79952129518 scopus 로고    scopus 로고
    • In vivo activation of ROCK1 by insulin is impaired in skelet al muscle of humans with type 2 diabetes
    • Chun KH, Choi KD, Lee DH, et al. In vivo activation of ROCK1 by insulin is impaired in skelet al muscle of humans with type 2 diabetes. Am J Physiol Endocrinol Metab. 2010;300:E536-E542.
    • (2010) Am J Physiol Endocrinol Metab. , vol.300
    • Chun, K.H.1    Choi, K.D.2    Lee, D.H.3
  • 40
    • 18044373207 scopus 로고    scopus 로고
    • Fenofibrate induces apoptotic injury in cultured human hepatocytes by inhibiting phosphorylation of Akt
    • Kubota T, Yano T, Fujisaki K, Itoh Y, Oishi R. Fenofibrate induces apoptotic injury in cultured human hepatocytes by inhibiting phosphorylation of Akt. Apoptosis. 2005;10:349-358.
    • (2005) Apoptosis. , vol.10 , pp. 349-358
    • Kubota, T.1    Yano, T.2    Fujisaki, K.3    Itoh, Y.4    Oishi, R.5
  • 41
    • 33744797915 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha activation decreases metastatic potential of melanoma cells in vitro via down-regulation of Akt
    • Grabacka M, Plonka PM, Urbanska K, Reiss K. Peroxisome proliferator-activated receptor alpha activation decreases metastatic potential of melanoma cells in vitro via down-regulation of Akt. Clin Cancer Res. 2006;12:3028-3036.
    • (2006) Clin Cancer Res. , vol.12 , pp. 3028-3036
    • Grabacka, M.1    Plonka, P.M.2    Urbanska, K.3    Reiss, K.4
  • 42
    • 78651073543 scopus 로고    scopus 로고
    • Dietary monounsaturated fatty acids but not saturated fatty acids preserve the insulin signaling pathway via IRS-1/PI3K in rat skelet al muscle
    • Moon JH, Lee JY, Kang SB, et al. Dietary monounsaturated fatty acids but not saturated fatty acids preserve the insulin signaling pathway via IRS-1/PI3K in rat skelet al muscle. Lipids. 2010;45:1109-1116.
    • (2010) Lipids. , vol.45 , pp. 1109-1116
    • Moon, J.H.1    Lee, J.Y.2    Kang, S.B.3
  • 43
    • 0344855590 scopus 로고    scopus 로고
    • Insulin-induced tyrosine phosphorylation of Shc in liver, muscle and adipose tissue of insulin resistant rats
    • Páez-Espinosa EV, Rocha EM, Velloso LA, Boschero AC, Saad MJ. Insulin-induced tyrosine phosphorylation of Shc in liver, muscle and adipose tissue of insulin resistant rats. Mol Cell Endocrinol. 1999;156: 121-129.
    • (1999) Mol Cell Endocrinol. , vol.156 , pp. 121-129
    • Páez-Espinosa, E.V.1    Rocha, E.M.2    Velloso, L.A.3    Boschero, A.C.4    Saad, M.J.5
  • 44
    • 79953115098 scopus 로고    scopus 로고
    • The effects of dietary obesity on protein expressions of insulin signaling pathway in rat aorta
    • Fatani S, Naderali EK, Panchiani S, Shah F, Wong C. The effects of dietary obesity on protein expressions of insulin signaling pathway in rat aorta. Drug Discov Ther. 2008;2:254-261.
    • (2008) Drug Discov Ther. , vol.2 , pp. 254-261
    • Fatani, S.1    Naderali, E.K.2    Panchiani, S.3    Shah, F.4    Wong, C.5
  • 45
    • 33749442351 scopus 로고    scopus 로고
    • TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents
    • Valerio A, Cardile A, Cozzi V, et al. TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. J Clin Invest. 2006;116:2791-2798.
    • (2006) J Clin Invest. , vol.116 , pp. 2791-2798
    • Valerio, A.1    Cardile, A.2    Cozzi, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.