Glycocapture-assisted global quantitative proteomics (gagQP) reveals multiorgan responses in serum toxicoproteome

Journal of Proteome Research

Volumn 12, Issue 5, 2013, Pages 2034-2044

  Sun, Bingyun ^a,b   Utleg, Angelita G ^a   Hu, Zhiyuan ^a   Qin, Shizhen ^a   Keller, Andrew ^a   Lorang, Cynthia ^a   Gray, Li ^a   Brightman, Amy ^a   Lee, Denis ^a   Alexander, Vinita M ^a   Ranish, Jeffrey A ^a   Moritz, Robert L ^a   Hood, Leroy ^a  

^a INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^b SIMON FRASER UNIVERSITY   (Canada)

Author keywords

acetaminophen; biomarker; blood proteomics; drug toxicity; glycopeptide capture; glycoprotein enrichment; multiorgan responses; N glycosylation; organ specific proteins; toxicoproteomics; xenobiotic toxicity

Indexed keywords

PARACETAMOL; PROTEOME; TOXICOPROTEOME; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLYCOSYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEOMICS; QUANTITATIVE ANALYSIS; WESTERN BLOTTING;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; BLOOD PROTEINS; DRUG-INDUCED LIVER INJURY; GLYCOPEPTIDES; GLYCOSYLATION; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE ANNOTATION; ORGAN SPECIFICITY; PROTEIN INTERACTION MAPS; PROTEOME;

EID: 84877123905     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr301178a     Document Type: Article

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