Evaluation of human hepatocyte chimeric mice as a model for toxicological investigation using panomic approaches - Effect of acetaminophen on the expression profiles of proteins and endogenous metabolites in liver, plasma and urine

Journal of Toxicological Sciences

Volumn 32, Issue 3, 2007, Pages 205-215

  Yamamoto, Toshinori ^a   Tomizawa, Kaori ^a   Fujikawa, Masaaki ^a   Sato, Yasushi ^a   Yamada, Hiroshi ^a   Horii, Ikuo ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Acetaminophen; Chimeric mice; Metabonomics; Proteomics

Indexed keywords

PARACETAMOL;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHIMERA; CITRIC ACID CYCLE; CONTROLLED STUDY; DRUG OVERDOSE; ENERGY METABOLISM; EVALUATION; FATTY ACID METABOLISM; GLYCOLYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIPID METABOLISM; LIVER CELL; LIVER TOXICITY; METABOLITE; METABONOMICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PLASMA; PROTEIN EXPRESSION; PROTEOMICS; PROTON NUCLEAR MAGNETIC RESONANCE; TWO DIMENSIONAL GEL ELECTROPHORESIS; URINE;

MUS;

EID: 34548626321     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.32.205     Document Type: Article

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