Agonist-induced down-regulation of endogenous protein kinase C α through an endolysosomal mechanism

Journal of Biological Chemistry

Volumn 288, Issue 18, 2013, Pages 13093-13109

  Lum, Michelle A ^a,b   Pundt, Krista E ^b   Paluch, Benjamin E ^b   Black, Adrian R ^a,b   Black, Jennifer D ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL DEPLETION; DOMINANT-NEGATIVE MUTANTS; INTRACELLULAR ACCUMULATION; LYSOSOMAL DEGRADATION; PHARMACOLOGICAL INHIBITORS; PHOSPHORYLATED PROTEINS; PROTEASOMAL DEGRADATION; SUBCELLULAR COMPARTMENTS;

CELL MEMBRANES; PROTEINS; RNA;

ENZYME INHIBITION;

CHOLESTEROL; CLATHRIN; DYNAMIN; GUANOSINE TRIPHOSPHATASE; LEUPEPTIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MUTANT PROTEIN; PROTEASOME; PROTEIN KINASE C ALPHA; RAB7 PROTEIN;

ANIMAL CELL; ARTICLE; CAVEOLA; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CELL NUCLEUS; CELL VACUOLE; CONTROLLED STUDY; DESENSITIZATION; DOWN REGULATION; ENDOCYTOSIS; ENDOSOME; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; INTERNALIZATION; LIPID RAFT; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN LIPID INTERACTION; PROTEIN PROCESSING; PROTEIN TRANSPORT; RAT; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

CAVEOLAE; ENDOCYTOSIS; LIPID RAFT; LYSOSOMAL; LYSOSOMES; PKCΑ DEGRADATION; PROTEIN DEGRADATION; PROTEIN KINASE C (PKC);

ANIMALS; DOWN-REGULATION; ENDOSOMES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELA CELLS; HUMANS; LYSOSOMES; MEMBRANE MICRODOMAINS; PHOSPHORYLATION; PROTEIN KINASE C-ALPHA; PROTEIN TRANSPORT; PROTEOLYSIS; RAB GTP-BINDING PROTEINS; RATS; VESICULAR TRANSPORT PROTEINS;

EID: 84877120726     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.437061     Document Type: Article

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