Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation

Trends in Cell Biology

Volumn 16, Issue 12, 2006, Pages 607-609

  Nankoe, Sharif R ^a   Sever, Sanja ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; DYNAMIN; DYNASORE; ENZYME INHIBITOR; GUANOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG;

CELL TRANSPORT; COATED VESICLE; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GENE EXPRESSION; GOLGI COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SHORT SURVEY;

ANIMALS; CELL MEMBRANE STRUCTURES; CLATHRIN; CLATHRIN-COATED VESICLES; DYNAMINS; ENDOCYTOSIS; HUMANS; HYDRAZONES; MODELS, BIOLOGICAL;

EID: 33751337381     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2006.10.004     Document Type: Short Survey

References (22)

1. Kirchhausen T. Three ways to make a vesicle. Nat. Rev. Mol. Cell Biol. 1 (2000) 187-198
2. Macia E., et al. Dynasore, a cell-permeable inhibitor of dynamin. Dev. Cell 10 (2006) 839-850
3. ts1. J. Cell Biol. 97 (1983) 499-507
4. Damke H., et al. Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. J. Cell Biol. 127 (1994) 915-934
5. van der Bliek A.M., et al. Mutations in human dynamin block an intermediate stage in coated vesicle formation. J. Cell Biol. 122 (1993) 553-563
6. Damke H., et al. Dynamin GTPase domain mutants block endocytic vesicle formation at morphologically distinct stages. Mol. Biol. Cell 12 (2001) 2578-2589
7. Damke H., et al. Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin. J. Cell Biol. 131 (1995) 69-80
8. Narayanan R., et al. An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function. J. Cell Biol. 169 (2005) 117-126
9. Carter L.L., et al. Multiple GTP-binding proteins participate in clathrin-coated vesicle-mediated endocytosis. J. Cell Biol. 120 (1993) 37-45
10. Sever S., et al. Dynamin:GTP controls formation of constricted coated pits, the rate limiting step in clathrin-mediated endocytosis. J. Cell Biol. 150 (2000) 1137-1147
11. Subtil A., et al. Acute cholesterol depletion inhibits clathrin-coated pit budding. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 6775-6780
12. Ringstad N., et al. Endophilin/SH3p4 is required for the transition from early to late stages in clathrin-mediated synaptic vesicle endocytosis. Neuron 24 (1999) 143-154
13. Kosaka T., and Ikeda K. Possible temperature-dependent blockage of synaptic vesicle recycling induced by a single gene mutation in Drosophila. J. Neurobiol. 14 (1983) 207-225
14. Takei K., et al. Tubular membrane invaginations coated by dynamin rings are induced by GTPγS in nerve terminals. Nature 374 (1995) 186-190
15. Carr J.F., and Hinshaw J.E. Dynamin assembles into spirals under physiological salt conditions upon the addition of GDP and gamma-phosphate analogues. J. Biol. Chem. 272 (1997) 28030-28035
16. Praefcke G.J., and McMahon H.T. The dynamin superfamily: universal membrane tubulation and fission molecules?. Nat. Rev. Mol. Cell Biol. 5 (2004) 133-147
17. McMahon H.T., and Gallop J.L. Membrane curvature and mechanisms of dynamic cell membrane remodelling. Nature 438 (2005) 590-596
18. Roux A., et al. GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission. Nature 441 (2006) 528-531
19. Sever S., et al. Physical and functional connection between auxilin and dynamin during endocytosis. EMBO J 25 (2006) 4163-4174
20. Dawson J.C., et al. Bar domain proteins: a role in tubulation, scission and actin assembly in clathrin-mediated endocytosis. Trends Cell Biol. 16 (2006) 493-498
21. Newmyer S.L., et al. Auxilin-dynamin interactions link the uncoating ATPase chaperone machinery with vesicle formation. Dev. Cell 4 (2003) 929-940
22. Schafer D.A. Regulating actin dynamics at membranes: a focus on dynamin. Traffic 5 (2004) 463-469