IL-17 induces type V collagen overexpression and EMT via TGF-β-dependent pathways in obliterative bronchiolitis

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 304, Issue 6, 2013, Pages

  Vittal, Ragini ^a   Fan, Lin ^a   Greenspan, Daniel S ^b   Mickler, Elizabeth A ^a   Gopalakrishnan, Bagavathi ^b   Gu, Hongmei ^a   Benson, Heather L ^a   Zhang, Chen ^a   Burlingham, William ^b   Cummings, Oscar W ^a   Wilkes, David S ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Autoimmunity; Epithelial mesenchymal transition; Focal adhesion kinase; Mouse transplant model; p38 MAPK; RLE 6TN; Small airway epithelial cells

Indexed keywords

COLLAGEN ANTIBODY; COLLAGEN TYPE 1; COLLAGEN TYPE 1ALPHA; COLLAGEN TYPE 5; FOCAL ADHESION KINASE; INTERLEUKIN 17; INTERLEUKIN 17 ANTIBODY; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG; AUTOANTIBODY; COL5A1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; BRONCHIOLITIS OBLITERANS; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; GENE OVEREXPRESSION; GRAFT RECIPIENT; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ALVEOLUS EPITHELIUM; LUNG BIOPSY; LUNG LAVAGE; LUNG TRANSPLANTATION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESPIRATORY EPITHELIUM; WESTERN BLOTTING; ANIMAL; BRONCHITIS; CELL CULTURE; CELL MOTION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; PRIMARY CELL CULTURE; RESPIRATORY TRACT MUCOSA; SIGNAL TRANSDUCTION;

ANIMALS; AUTOANTIBODIES; BRONCHITIS; CELL MOVEMENT; CELLS, CULTURED; COLLAGEN TYPE V; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-17; LUNG TRANSPLANTATION; MALE; MICE; MIDDLE AGED; PRIMARY CELL CULTURE; RATS; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

MLCS; MLOWN;

EID: 84877105274     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00080.2012     Document Type: Article

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