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Volumn 288, Issue 18, 2013, Pages 12615-12626

Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN-DEPENDENT KINASE; HUMAN CANCER CELLS; HYDROLASE ACTIVITIES; INTERACTION LEVELS; KINASE ACTIVITY; MOLECULAR FUNCTION; MULTIPLE CELL TYPES; RNA INTERFERENCE;

EID: 84877103246     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.435701     Document Type: Article
Times cited : (39)

References (57)
  • 1
    • 0031466305 scopus 로고    scopus 로고
    • Cyclin-dependent kinases. Engines, clocks, and microprocessors
    • Morgan, D. O. (1997) Cyclin-dependent kinases. Engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol. 13, 261-291
    • (1997) Annu. Rev. Cell Dev. Biol. , vol.13 , pp. 261-291
    • Morgan, D.O.1
  • 2
    • 0028122011 scopus 로고
    • A brain-specific activator of cyclin-dependent kinase 5
    • DOI 10.1038/371423a0
    • Lew, J., Huang, Q. Q., Qi, Z., Winkfein, R. J., Aebersold, R., Hunt, T., and Wang, J. H. (1994) A brain-specific activator of cyclin-dependent kinase 5. Nature 371, 423-426 (Pubitemid 24302557)
    • (1994) Nature , vol.371 , Issue.6496 , pp. 423-426
    • Lew, J.1    Huang, Q.-Q.2    Qi, Z.3    Winkfein, R.J.4    Aebersold, R.5    Hunt, T.6    Wang, J.H.7
  • 3
    • 0029966469 scopus 로고    scopus 로고
    • The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation
    • Nikolic, M., Dudek, H., Kwon, Y. T., Ramos, Y. F., and Tsai, L. H. (1996) The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Genes Dev. 10, 816-825 (Pubitemid 26114738)
    • (1996) Genes and Development , vol.10 , Issue.7 , pp. 816-825
    • Nikolic, M.1    Dudek, H.2    Kwon, Y.T.3    Ramos, Y.F.M.4    Tsai, L.-H.5
  • 4
    • 0028568315 scopus 로고
    • Cell cycle control and cancer
    • Hartwell, L. H., and Kastan, M. B. (1994) Cell cycle control and cancer. Science 266, 1821-1828
    • (1994) Science , vol.266 , pp. 1821-1828
    • Hartwell, L.H.1    Kastan, M.B.2
  • 5
    • 0344241479 scopus 로고    scopus 로고
    • Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease
    • Yang, Y., Mufson, E. J., and Herrup, K. (2003) Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease. J. Neurosci. 23, 2557-2563 (Pubitemid 36418589)
    • (2003) Journal of Neuroscience , vol.23 , Issue.7 , pp. 2557-2563
    • Yang, Y.1    Mufson, E.J.2    Herrup, K.3
  • 7
    • 0024461942 scopus 로고
    • The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase
    • Wilkinson, K. D., Lee, K. M., Deshpande, S., Duerksen-Hughes, P., Boss, J. M., and Pohl, J. (1989) The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. Science 246, 670-673 (Pubitemid 19283361)
    • (1989) Science , vol.246 , Issue.4930 , pp. 670-673
    • Wilkinson, K.D.1    Lee, K.2    Deshpande, S.3    Duerksen-Hughes, P.4    Boss, J.M.5    Pohl, J.6
  • 11
    • 0034489892 scopus 로고    scopus 로고
    • PGP9.5 as a prognostic factor in pancreatic cancer
    • Tezel, E., Hibi, K., Nagasaka, T., and Nakao, A. (2000) PGP9.5 as a prognostic factor in pancreatic cancer. Clin. Cancer Res. 6, 4764-4767 (Pubitemid 32110417)
    • (2000) Clinical Cancer Research , vol.6 , Issue.12 , pp. 4764-4767
    • Tezel, E.1    Hibi, K.2    Nagasaka, T.3    Nakao, A.4
  • 14
    • 33744510119 scopus 로고    scopus 로고
    • High expression of ubiquitin caboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer
    • DOI 10.1111/j.1349-7006.2006.00202.x
    • Miyoshi, Y., Nakayama, S., Torikoshi, Y., Tanaka, S., Ishihara, H., Taguchi, T., Tamaki, Y., and Noguchi, S. (2006) High expression of ubiquitin carboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer. Cancer Sci. 97, 523-529 (Pubitemid 43811594)
    • (2006) Cancer Science , vol.97 , Issue.6 , pp. 523-529
    • Miyoshi, Y.1    Nakayama, S.2    Torikoshi, Y.3    Tanaka, S.4    Ishihara, H.5    Taguchi, T.6    Tamaki, Y.7    Noguchi, S.8
  • 17
    • 0025835391 scopus 로고
    • "Neuron-specific" protein gene product 9.5 (PGP 9.5) is also expressed in glioma cell lines and its expression depends on cellular growth state
    • Giambanco, I., Bianchi, R., Ceccarelli, P., Pula, G., Sorci, G., Antonioli, S., Bocchini, V., and Donato, R. (1991) "Neuron-specific" protein gene product 9.5 (PGP 9.5) is also expressed in glioma cell lines and its expression depends on cellular growth state. FEBS Lett. 290, 131-134
    • (1991) FEBS Lett. , vol.290 , pp. 131-134
    • Giambanco, I.1    Bianchi, R.2    Ceccarelli, P.3    Pula, G.4    Sorci, G.5    Antonioli, S.6    Bocchini, V.7    Donato, R.8
  • 19
    • 0028870636 scopus 로고
    • Induced expression of a ubiquitin COOH-terminal hydrolase in acute lymphoblastic leukemia
    • Al-Katib, A. M., Mohammad, R. M., Maki, A., and Smith, M. R. (1995) Induced expression of a ubiquitin COOH-terminal hydrolase in acute lymphoblastic leukemia. Cell Growth & Differ. 6, 211-217
    • (1995) Cell Growth & Differ. , vol.6 , pp. 211-217
    • Al-Katib, A.M.1    Mohammad, R.M.2    Maki, A.3    Smith, M.R.4
  • 20
    • 77956422832 scopus 로고    scopus 로고
    • The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling
    • Hussain, S., Foreman, O., Perkins, S. L., Witzig, T. E., Miles, R. R., van Deursen, J., and Galardy, P. J. (2010) The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling. Leukemia 24, 1641-1655
    • (2010) Leukemia , vol.24 , pp. 1641-1655
    • Hussain, S.1    Foreman, O.2    Perkins, S.L.3    Witzig, T.E.4    Miles, R.R.5    Van Deursen, J.6    Galardy, P.J.7
  • 24
    • 0032502276 scopus 로고    scopus 로고
    • Substrate specificity of deubiquitinating enzymes: Ubiquitin C-terminal hydrolases
    • DOI 10.1021/bi972274d
    • Larsen, C. N., Krantz, B. A., and Wilkinson, K. D. (1998) Substrate specificity of deubiquitinating enzymes. Ubiquitin C-terminal hydrolases. Biochemistry 37, 3358-3368 (Pubitemid 28125563)
    • (1998) Biochemistry , vol.37 , Issue.10 , pp. 3358-3368
    • Larsen, C.N.1    Krantz, B.A.2    Wilkinson, K.D.3
  • 25
    • 0037131567 scopus 로고    scopus 로고
    • The UCH-L1 gene encodes two opposing enzymatic activities that affect α-synuclein degradation and Parkinson's disease susceptibility
    • DOI 10.1016/S0092-8674(02)01012-7
    • Liu, Y., Fallon, L., Lashuel, H. A., Liu, Z., and Lansbury, P. T., Jr. (2002) The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell 111, 209-218 (Pubitemid 35292441)
    • (2002) Cell , vol.111 , Issue.2 , pp. 209-218
    • Liu, Y.1    Fallon, L.2    Lashuel, H.A.3    Liu, Z.4    Lansbury Jr., P.T.5
  • 27
    • 43049093757 scopus 로고    scopus 로고
    • Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1
    • DOI 10.1093/hmg/ddn037
    • Kabuta, T., Setsuie, R., Mitsui, T., Kinugawa, A., Sakurai, M., Aoki, S., Uchida, K., and Wada, K. (2008) Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1. Hum. Mol. Genet. 17, 1482-1496 (Pubitemid 351627344)
    • (2008) Human Molecular Genetics , vol.17 , Issue.10 , pp. 1482-1496
    • Kabuta, T.1    Setsuie, R.2    Mitsui, T.3    Kinugawa, A.4    Sakurai, M.5    Aoki, S.6    Uchida, K.7    Wada, K.8
  • 28
    • 53049101345 scopus 로고    scopus 로고
    • Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy
    • Kabuta, T., Furuta, A., Aoki, S., Furuta, K., and Wada, K. (2008) Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. J. Biol. Chem. 283, 23731-23738
    • (2008) J. Biol. Chem. , vol.283 , pp. 23731-23738
    • Kabuta, T.1    Furuta, A.2    Aoki, S.3    Furuta, K.4    Wada, K.5
  • 29
    • 50249146177 scopus 로고    scopus 로고
    • Insights into links between familial and sporadic Parkinson's disease. Physical relationship between UCH-L1 variants and chaperone-mediated autophagy
    • Kabuta, T., and Wada, K. (2008) Insights into links between familial and sporadic Parkinson's disease. Physical relationship between UCH-L1 variants and chaperone-mediated autophagy. Autophagy 4, 827-829
    • (2008) Autophagy , vol.4 , pp. 827-829
    • Kabuta, T.1    Wada, K.2
  • 30
    • 33745761009 scopus 로고    scopus 로고
    • UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity
    • DOI 10.1038/sj.emboj.7601149, PII 7601149
    • Malakhova, O. A., Kim, K. I., Luo, J. K., Zou, W., Kumar, K. G., Fuchs, S. Y., Shuai, K., and Zhang, D. E. (2006) UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. EMBO J. 25, 2358-2367 (Pubitemid 44012219)
    • (2006) EMBO Journal , vol.25 , Issue.11 , pp. 2358-2367
    • Malakhova, O.A.1    Kim, K.I.2    Luo, J.-K.3    Zou, W.4    Kumar, K.G.S.5    Fuchs, S.Y.6    Shuai, K.7    Zhang, D.-E.8
  • 31
    • 33750089740 scopus 로고    scopus 로고
    • Degradation of amyotrophic lateral sclerosis-linked mutant Cu,Zn-superoxide dismutase proteins by macroautophagy and the proteasome
    • DOI 10.1074/jbc.M603337200
    • Kabuta, T., Suzuki, Y., and Wada, K. (2006) Degradation of amyotrophic lateral sclerosis-linked mutant Cu,Zn-superoxide dismutase proteins by macroautophagy and the proteasome. J. Biol. Chem. 281, 30524-30533 (Pubitemid 44582109)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.41 , pp. 30524-30533
    • Kabuta, T.1    Suzuki, Y.2    Wada, K.3
  • 33
    • 78649629032 scopus 로고    scopus 로고
    • TDP-43 physically interacts with amyotrophic lateral sclerosis-linked mutant CuZn superoxide dismutase
    • Higashi, S., Tsuchiya, Y., Araki, T., Wada, K., and Kabuta, T. (2010) TDP-43 physically interacts with amyotrophic lateral sclerosis-linked mutant CuZn superoxide dismutase. Neurochem. Int. 57, 906-913
    • (2010) Neurochem. Int. , vol.57 , pp. 906-913
    • Higashi, S.1    Tsuchiya, Y.2    Araki, T.3    Wada, K.4    Kabuta, T.5
  • 34
    • 78651325259 scopus 로고    scopus 로고
    • GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation
    • Higashi, S., Iseki, E., Minegishi, M., Togo, T., Kabuta, T., and Wada, K. (2010) GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation. J. Neurochem. 115, 423-437
    • (2010) J. Neurochem. , vol.115 , pp. 423-437
    • Higashi, S.1    Iseki, E.2    Minegishi, M.3    Togo, T.4    Kabuta, T.5    Wada, K.6
  • 35
    • 0036510379 scopus 로고    scopus 로고
    • Insulin receptor substrate-3 functions as transcriptional activator in the nucleus
    • DOI 10.1074/jbc.M107058200
    • Kabuta, T., Hakuno, F., Asano, T., and Takahashi, S. (2002) Insulin receptor substrate-3 functions as transcriptional activator in the nucleus. J. Biol. Chem. 277, 6846-6851 (Pubitemid 34953067)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.9 , pp. 6846-6851
    • Kabuta, T.1    Hakuno, F.2    Asano, T.3    Takahashi, S.-I.4
  • 37
    • 56049084412 scopus 로고    scopus 로고
    • Differential subcellular localization of insulin receptor substrates depends on C-terminal regions and importin beta
    • Kabuta, T., Take, K., Kabuta, C., Hakuno, F., and Takahashi, S. (2008) Differential subcellular localization of insulin receptor substrates depends on C-terminal regions and importin beta. Biochem. Biophys. Res. Commun. 377, 741-746
    • (2008) Biochem. Biophys. Res. Commun. , vol.377 , pp. 741-746
    • Kabuta, T.1    Take, K.2    Kabuta, C.3    Hakuno, F.4    Takahashi, S.5
  • 39
    • 30344457896 scopus 로고    scopus 로고
    • kip1 contributing to actin organization and cortical neuronal migration
    • DOI 10.1038/ncb1338, PII N1338
    • Kawauchi, T., Chihama, K., Nabeshima, Y., and Hoshino, M. (2006) Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration. Nat. Cell Biol. 8, 17-26 (Pubitemid 43064793)
    • (2006) Nature Cell Biology , vol.8 , Issue.1 , pp. 17-26
    • Kawauchi, T.1    Chihama, K.2    Nabeshima, Y.-I.3    Hoshino, M.4
  • 43
    • 0030051865 scopus 로고    scopus 로고
    • Identification of evolutionary conserved regulatory sequences in the 5′ untranscribed region of the neural-specific ubiquitin C-terminal hydrolase (PGP9.5) gene
    • Mann, D. A., Trowern, A. R., Lavender, F. L., Whittaker, P. A., and Thompson, R. J. (1996) Identification of evolutionary conserved regulatory sequences in the 5′ untranscribed region of the neural-specific ubiquitin C-terminal hydrolase (PGP9.5) gene. J. Neurochem. 66, 35-46
    • (1996) J. Neurochem. , vol.66 , pp. 35-46
    • Mann, D.A.1    Trowern, A.R.2    Lavender, F.L.3    Whittaker, P.A.4    Thompson, R.J.5
  • 44
    • 52049095054 scopus 로고    scopus 로고
    • Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability
    • Kaminosono, S., Saito, T., Oyama, F., Ohshima, T., Asada, A., Nagai, Y., Nukina, N., and Hisanaga, S. (2008) Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability. J. Neurosci. 28, 8747-8755
    • (2008) J. Neurosci. , vol.28 , pp. 8747-8755
    • Kaminosono, S.1    Saito, T.2    Oyama, F.3    Ohshima, T.4    Asada, A.5    Nagai, Y.6    Nukina, N.7    Hisanaga, S.8
  • 45
    • 0028931265 scopus 로고
    • Principles of CDK regulation
    • Morgan, D. O. (1995) Principles of CDK regulation. Nature 374, 131-134
    • (1995) Nature , vol.374 , pp. 131-134
    • Morgan, D.O.1
  • 46
    • 0037676148 scopus 로고    scopus 로고
    • Characterization of the testis in congenitally ubiquitin carboxy-terminal hydrolase-1 (Uch-L1) defective (gad) mice
    • DOI 10.1538/expanim.52.1
    • Kwon, J., Kikuchi, T., Setsuie, R., Ishii, Y., Kyuwa, S., and Yoshikawa, Y. (2003) Characterization of the testis in congenitally ubiquitin carboxy-terminal hydrolase-1 (Uch-L1) defective (gad) mice. Exp. Anim. 52, 1-9 (Pubitemid 41349985)
    • (2003) Experimental Animals , vol.52 , Issue.1 , pp. 1-9
    • Kwon, J.1    Kikuchi, T.2    Setsuie, R.3    Ishii, Y.4    Kyuwa, S.5    Yoshikawa, Y.6
  • 48
    • 0032937751 scopus 로고    scopus 로고
    • Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia
    • Rane, S. G., Dubus, P., Mettus, R. V., Galbreath, E. J., Boden, G., Reddy, E. P., and Barbacid, M. (1999) Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia. Nat. Genet. 22, 44-52
    • (1999) Nat. Genet. , vol.22 , pp. 44-52
    • Rane, S.G.1    Dubus, P.2    Mettus, R.V.3    Galbreath, E.J.4    Boden, G.5    Reddy, E.P.6    Barbacid, M.7
  • 50
    • 58149350275 scopus 로고    scopus 로고
    • Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis
    • Kim, H. J., Kim, Y. M., Lim, S., Nam, Y. K., Jeong, J., Kim, H. J., and Lee, K. J. (2009) Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis. Oncogene 28, 117-127
    • (2009) Oncogene , vol.28 , pp. 117-127
    • Kim, H.J.1    Kim, Y.M.2    Lim, S.3    Nam, Y.K.4    Jeong, J.5    Kim, H.J.6    Lee, K.J.7
  • 54
    • 0030921323 scopus 로고    scopus 로고
    • Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease
    • McShea, A., Harris, P. L., Webster, K. R., Wahl, A. F., and Smith, M. A. (1997) Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am. J. Pathol. 150, 1933-1939 (Pubitemid 27233067)
    • (1997) American Journal of Pathology , vol.150 , Issue.6 , pp. 1933-1939
    • McShea, A.1    Harris, P.L.R.2    Webster, K.R.3    Wahl, A.F.4    Smith, M.A.5
  • 55
    • 0032522911 scopus 로고    scopus 로고
    • Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain
    • Busser, J., Geldmacher, D. S., and Herrup, K. (1998) Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. J. Neurosci. 18, 2801-2807 (Pubitemid 28163210)
    • (1998) Journal of Neuroscience , vol.18 , Issue.8 , pp. 2801-2807
    • Busser, J.1    Geldmacher, D.S.2    Herrup, K.3
  • 56
    • 0031043049 scopus 로고    scopus 로고
    • Expression of cell division markers in the hippocampus in Alzheimer's disease and other nenrodegenerative conditions
    • DOI 10.1007/s004010050617
    • Nagy, Z., Esiri, M. M., and Smith, A. D. (1997) Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions. Acta Neuropathol. 93, 294-300 (Pubitemid 27104426)
    • (1997) Acta Neuropathologica , vol.93 , Issue.3 , pp. 294-300
    • Nagy, Z.1    Esiri, M.M.2    Smith, A.D.3
  • 57
    • 0030454478 scopus 로고    scopus 로고
    • Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease
    • Arendt, T., Rödel, L., Gärtner, U., and Holzer, M. (1996) Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease. Neuroreport. 7, 3047-3049 (Pubitemid 26426387)
    • (1996) NeuroReport , vol.7 , Issue.18 , pp. 3047-3049
    • Arendt, T.1    Rodel, L.2    Gartner, U.3    Holzer, M.4


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