-
2
-
-
1042299972
-
Evidence for an intermediate in tau filament formation
-
Chirita CN, Kuret J (2004) Evidence for an intermediate in tau filament formation. Biochemistry 43, 1704-1714
-
(2004)
Biochemistry
, vol.43
, pp. 1704-1714
-
-
Chirita, C.N.1
Kuret, J.2
-
3
-
-
1542327644
-
Ligand-dependent inhibition and reversal of tau filament formation
-
Chirita C, Necula M, Kuret J (2004) Ligand-dependent inhibition and reversal of tau filament formation. Biochemistry 43, 2879-2887
-
(2004)
Biochemistry
, vol.43
, pp. 2879-2887
-
-
Chirita, C.1
Necula, M.2
Kuret, J.3
-
4
-
-
0033850407
-
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
-
Buee L, Bussiere T, Buee-Scherrer V, Delacourte A, Hof PR (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev 33, 95-130
-
(2000)
Brain Res Brain Res Rev
, vol.33
, pp. 95-130
-
-
Buee, L.1
Bussiere, T.2
Buee-Scherrer, V.3
Delacourte, A.4
Hof, P.R.5
-
5
-
-
33847239940
-
Structural principles of tau and the paired helical filaments of Alzheimer's disease
-
Mandelkow E, von Bergen M, Biernat J, Mandelkow EM (2007) Structural principles of tau and the paired helical filaments of Alzheimer's disease. Brain Pathol 17, 83-90
-
(2007)
Brain Pathol
, vol.17
, pp. 83-90
-
-
Mandelkow, E.1
Von Bergen, M.2
Biernat, J.3
Mandelkow, E.M.4
-
6
-
-
17144395539
-
Triggers of full-length tau aggregation: A role for partially folded intermediates
-
Chirita CN, Congdon EE, Yin H, Kuret J (2005) Triggers of full-length tau aggregation: A role for partially folded intermediates. Biochemistry 44, 5862-5872
-
(2005)
Biochemistry
, vol.44
, pp. 5862-5872
-
-
Chirita, C.N.1
Congdon, E.E.2
Yin, H.3
Kuret, J.4
-
7
-
-
24144459823
-
Evaluating triggers and enhancers of tau fibrillization
-
Kuret J, Congdon EE, Li G, Yin H, Yu X, Zhong, Q (2005) Evaluating triggers and enhancers of tau fibrillization. Microsc Res Techn 67, 141-155
-
(2005)
Microsc Res Techn
, vol.67
, pp. 141-155
-
-
Kuret, J.1
Congdon, E.E.2
Li, G.3
Yin, H.4
Yu, X.5
Zhong, Q.6
-
8
-
-
10944273984
-
Pathways of tau fibrillization
-
Kuret J, Chirita CN, Congdon EE, KannanayakalT, Li G, Necula M, Yin H, Zhong Q (2005) Pathways of tau fibrillization. Biochim Biophys Acta 1739, 167-178
-
(2005)
Biochim Biophys Acta
, vol.1739
, pp. 167-178
-
-
Kuret, J.1
Chirita, C.N.2
Congdon, E.E.3
KannanayakalT Li, G.4
Necula, M.5
Yin, H.6
Zhong, Q.7
-
9
-
-
34447498400
-
Tau aggregation and toxicity in a cell culture model of tauopathy
-
Bandyopadhyay B, Li G, Yin H, Kuret J (2007) Tau aggregation and toxicity in a cell culture model of tauopathy. J Biol Chem 282, 16454-16464
-
(2007)
J Biol Chem
, vol.282
, pp. 16454-16464
-
-
Bandyopadhyay, B.1
Li, G.2
Yin, H.3
Kuret, J.4
-
10
-
-
79251555689
-
Methylene blue reduces abeta levels and rescues early cognitive deficit by increasing proteasome activity
-
Medina DX, Caccamo A, Oddo S (2011) Methylene blue reduces abeta levels and rescues early cognitive deficit by increasing proteasome activity. Brain Pathol 21, 140-149
-
(2011)
Brain Pathol
, vol.21
, pp. 140-149
-
-
Medina, D.X.1
Caccamo, A.2
Oddo, S.3
-
11
-
-
51349134160
-
Hope in Alzheimer's fight emerges from unexpected places
-
Gura T (2008) Hope in Alzheimer's fight emerges from unexpected places. Nat Med 14, 894
-
(2008)
Nat Med
, vol.14
, pp. 894
-
-
Gura, T.1
-
13
-
-
33745152289
-
Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo
-
Zilka N, Filipcik P, Koson P, Fialova L, Skrabana R, Zilkova M, Rolkova G, Kontsekova E, NovakM(2006) Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett 580, 3582-3588
-
(2006)
FEBS Lett
, vol.580
, pp. 3582-3588
-
-
Zilka, N.1
Filipcik, P.2
Koson, P.3
Fialova, L.4
Skrabana, R.5
Zilkova, M.6
Rolkova, G.7
Kontsekova, E.8
Novak, M.9
-
14
-
-
37549071037
-
Detection and quantification of tau aggregation using a membrane filter assay
-
Chang E, Kuret J (2008) Detection and quantification of tau aggregation using a membrane filter assay. Anal Biochem 373, 330-336
-
(2008)
Anal Biochem
, vol.373
, pp. 330-336
-
-
Chang, E.1
Kuret, J.2
-
15
-
-
0028246491
-
Twisted tubulofilaments of inclusion body myositis muscle resemble paired helical filaments of Alzheimer brain and contain hyperphosphorylated tau
-
Askanas V, Engel WK, Bilak M, Alvarez RB, Selkoe DJ (1994) Twisted tubulofilaments of inclusion body myositis muscle resemble paired helical filaments of Alzheimer brain and contain hyperphosphorylated tau. Am J Pathol 144, 177-187
-
(1994)
Am J Pathol
, vol.144
, pp. 177-187
-
-
Askanas, V.1
Engel, W.K.2
Bilak, M.3
Alvarez, R.B.4
Selkoe, D.J.5
-
16
-
-
84877141497
-
-
Chemical Computing Group
-
Chemical Computing Group, Montreal, Canada, http://www. chemcomp.com
-
Montreal Canada
-
-
-
17
-
-
21644446496
-
Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions
-
Mukrasch MD, Biernat J, von Bergen M, Griesinger C, Mandelkow E, Zweckstetter M (2005) Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions. J Biol Chem 280, 24978-24986
-
(2005)
J Biol Chem
, vol.280
, pp. 24978-24986
-
-
Mukrasch, M.D.1
Biernat, J.2
Von Bergen, M.3
Griesinger, C.4
Mandelkow, E.5
Zweckstetter, M.6
-
18
-
-
61349120815
-
Structural polymorphism of 441-residue tau at single residue resolution
-
Mukrasch MD, Bibow S, Korukottu J, Jeganathan S, Biernat J, Griesinger C, Mandelkow E, Zweckstetter M (2009) Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol 7, e34
-
(2009)
PLoS Biol
, vol.7
-
-
Mukrasch, M.D.1
Bibow, S.2
Korukottu, J.3
Jeganathan, S.4
Biernat, J.5
Griesinger, C.6
Mandelkow, E.7
Zweckstetter, M.8
-
19
-
-
28444442999
-
3D structure of Alzheimer's amyloid-beta (1-42) fibrils
-
Luhrs T, Ritter C, Adrian M, Riek-Loher D, Bohrmann B, Dobeli H, Schubert D, Riek R (2005) 3D structure of Alzheimer's amyloid-beta (1-42) fibrils. Proc Natl Acad Sci U S A 102, 17342-17347
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 17342-17347
-
-
Luhrs, T.1
Ritter, C.2
Adrian, M.3
Riek-Loher, D.4
Bohrmann, B.5
Dobeli, H.6
Schubert, D.7
Riek, R.8
-
20
-
-
79959791904
-
Towards a pharmacophore for amyloid
-
Landau M, Sawaya MR, Faull KF, Laganowsky A, Jiang L, Sievers SA, Liu J, Barrio JR, Eisenberg D (2011) Towards a pharmacophore for amyloid. PLoS Biol 9, e1001080
-
(2011)
PLoS Biol
, vol.9
-
-
Landau, M.1
Sawaya, M.R.2
Faull, K.F.3
Laganowsky, A.4
Jiang, L.5
Sievers, S.A.6
Liu, J.7
Barrio, J.R.8
Eisenberg, D.9
-
21
-
-
0035964342
-
Electrostatics of nanosystems: Application to microtubules and the ribosome
-
Baker NA, Sept D, Joseph S, Holst MJ, McCammon JA (2001) Electrostatics of nanosystems: Application to microtubules and the ribosome. Proc Natl Acad Sci U S A 98, 10037-10041
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10037-10041
-
-
Baker, N.A.1
Sept, D.2
Joseph, S.3
Holst, M.J.4
McCammon, J.A.5
-
22
-
-
3242886771
-
PDB2PQR: An automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations
-
Dolinsky TJ, Nielsen JE, McCammon JA, Baker NA (2004) PDB2PQR: An automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations. Nucleic Acids Res 32, W665-W667
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Dolinsky, T.J.1
Nielsen, J.E.2
McCammon, J.A.3
Baker, N.A.4
-
23
-
-
0041784950
-
All-Atom empirical potential for molecular modeling and dynamics studies of proteins
-
MacKerell AD, Bashford D, Dunbrack RL, Evanseck JD, Field MJ, Fischer S, Gao J, Guo H, Ha S, Joseph-McCarthyD, Kuchnir L, Kuczera K, Lau FTK, Mattos C, Michnick S, Ngo T, Nguyen DT, Prodhom B, Reiher WE, Roux B, Schlenkrich M, Smith JC, Stote R, Straub J, Watanabe M, Wíorkiewicz-Kuczera J, Yin D, Karplus M (1998) All-Atom empirical potential for molecular modeling and dynamics studies of proteins. J Phys Chem B 102, 3586-3516
-
(1998)
J Phys Chem B
, vol.102
, pp. 3586-3516
-
-
MacKerell, A.D.1
Bashford, D.2
Dunbrack, R.L.3
Evanseck, J.D.4
Field, M.J.5
Fischer, S.6
Gao, J.7
Guo, H.8
Ha, S.9
Joseph-McCarthy, D.10
Kuchnir, L.11
Kuczera, K.12
Lau, F.T.K.13
Mattos, C.14
Michnick, S.15
Ngo, T.16
Nguyen, D.T.17
Prodhom, B.18
Reiher, W.E.19
Roux, B.20
Schlenkrich, M.21
Smith, J.C.22
Stote, R.23
Straub, J.24
Watanabe, M.25
Wíorkiewicz- Kuczera, J.26
Yin, D.27
Karplus, M.28
more..
-
24
-
-
28644432877
-
Very fast empirical prediction and rationalization of protein pKa values
-
Li H, Robertson AD, Jensen JH (2005) Very fast empirical prediction and rationalization of protein pKa values. Proteins 61, 704-721
-
(2005)
Proteins
, vol.61
, pp. 704-721
-
-
Li, H.1
Robertson, A.D.2
Jensen, J.H.3
-
25
-
-
79954421528
-
Electrostatic clustering and free energy calculations provide a foundation for protein design and optimization
-
Gorham RD Jr., Kieslich CA, Morikis D (2011) Electrostatic clustering and free energy calculations provide a foundation for protein design and optimization. Ann Biomed Eng 39, 1252-1263
-
(2011)
Ann Biomed Eng
, vol.39
, pp. 1252-1263
-
-
Gorham Jr., R.D.1
Kieslich, C.A.2
Morikis, D.3
-
26
-
-
0029118487
-
A free energy analysis of nucleic acid base stacking in aqueous solution
-
Friedman RA, Honig B (1995) A free energy analysis of nucleic acid base stacking in aqueous solution. Biophys J 69, 1528-1535
-
(1995)
Biophys J
, vol.69
, pp. 1528-1535
-
-
Friedman, R.A.1
Honig, B.2
-
27
-
-
0035930625
-
Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure
-
von Bergen M, Barghorn S, Li L, Marx A, Biernat J, Mandelkow EM,Mandelkow E (2001) Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure. J Biol Chem 276, 48165-48174
-
(2001)
J Biol Chem
, vol.276
, pp. 48165-48174
-
-
Von Bergen, M.1
Barghorn, S.2
Li, L.3
Marx, A.4
Biernat, J.5
Mandelkow, E.M.6
Mandelkow, E.7
-
28
-
-
34249290108
-
Atomic structures of amyloid cross-beta spines reveal varied steric zippers
-
Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D (2007) Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature 447, 453-457
-
(2007)
Nature
, vol.447
, pp. 453-457
-
-
Sawaya, M.R.1
Sambashivan, S.2
Nelson, R.3
Ivanova, M.I.4
Sievers, S.A.5
Apostol, M.I.6
Thompson, M.J.7
Balbirnie, M.8
Wiltzius, J.J.9
McFarlane, H.T.10
Madsen, A.O.11
Riekel, C.12
Eisenberg, D.13
-
29
-
-
10944258455
-
Tau aggregation is driven by a transition from random coil to beta sheet structure
-
von Bergen M, Barghorn S, Biernat J, Mandelkow EM,Mandelkow E (2005) Tau aggregation is driven by a transition from random coil to beta sheet structure. Biochim Biophys Acta 1739, 158-166
-
(2005)
Biochim Biophys Acta
, vol.1739
, pp. 158-166
-
-
Von Bergen, M.1
Barghorn, S.2
Biernat, J.3
Mandelkow, E.M.4
Mandelkow, E.5
-
30
-
-
10944248857
-
Tau, tangles, and Alzheimer's disease
-
Binder LI, Guillozet-Bongaarts AL, Garcia-Sierra F, Berry RW (2005) Tau, tangles, and Alzheimer's disease. Biochim Biophys Acta 1739, 216-223
-
(2005)
Biochim Biophys Acta
, vol.1739
, pp. 216-223
-
-
Binder, L.I.1
Guillozet-Bongaarts, A.L.2
Garcia-Sierra, F.3
Berry, R.W.4
-
31
-
-
33749007666
-
Ultrastructural characteristics of tau filaments in tauopathies: Immuno-electron microscopic demonstration of tau filaments in tauopathies
-
ArimaK(2006) Ultrastructural characteristics of tau filaments in tauopathies: Immuno-electron microscopic demonstration of tau filaments in tauopathies. Neuropathology 26, 475-483
-
(2006)
Neuropathology
, vol.26
, pp. 475-483
-
-
Arima, K.1
-
32
-
-
77955927938
-
Tau protein and tau aggregation inhibitors
-
Bulic B, Pickhardt M, Mandelkow EM, Mandelkow E (2010) Tau protein and tau aggregation inhibitors. Neuropharmacology 59, 276-289
-
(2010)
Neuropharmacology
, vol.59
, pp. 276-289
-
-
Bulic, B.1
Pickhardt, M.2
Mandelkow, E.M.3
Mandelkow, E.4
-
33
-
-
0029742937
-
Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines
-
Wischik CM, Edwards PC, Lai RY, Roth M, Harrington CR (1996) Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. Proc Natl Acad Sci U S A 93, 11213-11218
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 11213-11218
-
-
Wischik, C.M.1
Edwards, P.C.2
Lai, R.Y.3
Roth, M.4
Harrington, C.R.5
-
34
-
-
0037126688
-
Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments
-
Barghorn S, Mandelkow E (2002) Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments. Biochemistry 41, 14885-14896
-
(2002)
Biochemistry
, vol.41
, pp. 14885-14896
-
-
Barghorn, S.1
Mandelkow, E.2
-
35
-
-
0034625060
-
Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif (306)VQIVYK 311)) forming beta structure
-
von Bergen M, Friedhoff P, Biernat J, Heberle J, Mandelkow EM, Mandelkow E (2000) Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK (311)) forming beta structure. Proc Natl Acad Sci U S A 97, 5129-5134
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 5129-5134
-
-
Von Bergen, M.1
Friedhoff, P.2
Biernat, J.3
Heberle, J.4
Mandelkow, E.M.5
Mandelkow, E.6
-
36
-
-
2442590898
-
Surfacedecoration of microtubules by human tau
-
Santarella RA, Skiniotis G, Goldie KN, Tittmann P, Gross H, Mandelkow EM, Mandelkow E, Hoenger A (2004) Surfacedecoration of microtubules by human tau. J Mol Biol 339, 539-553
-
(2004)
J Mol Biol
, vol.339
, pp. 539-553
-
-
Santarella, R.A.1
Skiniotis, G.2
Goldie, K.N.3
Tittmann, P.4
Gross, H.5
Mandelkow, E.M.6
Mandelkow, E.7
Hoenger, A.8
-
37
-
-
77349118694
-
Tau oligomers and aggregation in Alzheimer's disease
-
Meraz-Rios MA, Lira-De Leon KI, Campos-Pena V, De Anda-Hernandez MA, Mena-Lopez R (2010) Tau oligomers and aggregation in Alzheimer's disease. J Neurochem 112, 1353-1367
-
(2010)
J Neurochem
, vol.112
, pp. 1353-1367
-
-
Meraz-Rios, M.A.1
Lira-De Leon, K.I.2
Campos-Pena, V.3
De Anda-Hernandez, M.A.4
Mena-Lopez, R.5
-
38
-
-
3142699791
-
Template-Assisted filament growth by parallel stacking of tau
-
Margittai M, Langen R (2004) Template-Assisted filament growth by parallel stacking of tau. Proc Natl Acad Sci U S A 101, 10278-10283
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 10278-10283
-
-
Margittai, M.1
Langen, R.2
-
39
-
-
34249706348
-
The "jaws" of the tau-microtubule interaction
-
Mukrasch MD, von Bergen M, Biernat J, Fischer D, Griesinger C, Mandelkow E, Zweckstetter M (2007) The "jaws" of the tau-microtubule interaction. J Biol Chem 282, 12230-12239
-
(2007)
J Biol Chem
, vol.282
, pp. 12230-12239
-
-
Mukrasch, M.D.1
Von Bergen, M.2
Biernat, J.3
Fischer, D.4
Griesinger, C.5
Mandelkow, E.6
Zweckstetter, M.7
-
40
-
-
12344328360
-
Residual structure in the repeat domain of tau: Echoes of microtubule binding and paired helical filament formation
-
Eliezer D, Barre P, Kobaslija M, Chan D, Li X, Heend L (2005) Residual structure in the repeat domain of tau: Echoes of microtubule binding and paired helical filament formation. Biochemistry 44, 1026-1036
-
(2005)
Biochemistry
, vol.44
, pp. 1026-1036
-
-
Eliezer, D.1
Barre, P.2
Kobaslija, M.3
Chan, D.4
Li, X.5
Heend, L.6
-
41
-
-
3042602456
-
The formation of straight and twisted filaments from short tau peptides
-
Goux WJ, Kopplin L, Nguyen AD, Leak K, Rutkofsky M, Shanmuganandam VD, Sharma D, Inouye H, Kirschner DA (2004) The formation of straight and twisted filaments from short tau peptides. J Biol Chem 279, 26868-26875
-
(2004)
J Biol Chem
, vol.279
, pp. 26868-26875
-
-
Goux, W.J.1
Kopplin, L.2
Nguyen, A.D.3
Leak, K.4
Rutkofsky, M.5
Shanmuganandam, V.D.6
Sharma, D.7
Inouye, H.8
Kirschner, D.A.9
-
42
-
-
70349155427
-
Tau aggregation followed by atomic force microscopy and surface plasmon resonance, and single molecule tau-Tau interaction probed by atomic force spectroscopy
-
Barrantes A, Sotres J, Hernando-Perez M, Benitez MJ, de Pablo PJ, Baro AM, Avila J, Jimenez JS (2009) Tau aggregation followed by atomic force microscopy and surface plasmon resonance, and single molecule tau-Tau interaction probed by atomic force spectroscopy. J Alzheimers Dis 18, 141-151
-
(2009)
J Alzheimers Dis
, vol.18
, pp. 141-151
-
-
Barrantes, A.1
Sotres, J.2
Hernando-Perez, M.3
Benitez, M.J.4
De Pablo, P.J.5
Baro, A.M.6
Avila, J.7
Jimenez, J.S.8
-
43
-
-
47249159078
-
A soluble oligomer of tau associated with fiber formation analyzed by NMR
-
Peterson DW, Zhou H, Dahlquist FW, Lew J (2008) A soluble oligomer of tau associated with fiber formation analyzed by NMR. Biochemistry 47, 7393-7404
-
(2008)
Biochemistry
, vol.47
, pp. 7393-7404
-
-
Peterson, D.W.1
Zhou, H.2
Dahlquist, F.W.3
Lew, J.4
-
44
-
-
33846002029
-
Side chain-dependent stacking modulates tau filament structure
-
Margittai M, Langen R (2006) Side chain-dependent stacking modulates tau filament structure. J Biol Chem 281, 37820-37827
-
(2006)
J Biol Chem
, vol.281
, pp. 37820-37827
-
-
Margittai, M.1
Langen, R.2
-
45
-
-
58149174069
-
Formation and growth of oligomers: A Monte Carlo study of an amyloid tau fragment
-
Li DW, Mohanty S, Irback A, Huo S (2008) Formation and growth of oligomers: A Monte Carlo study of an amyloid tau fragment. PLoS Comput Biol 4, e1000238
-
(2008)
PLoS Comput Biol
, vol.4
-
-
Li, D.W.1
Mohanty, S.2
Irback, A.3
Huo, S.4
|