Electrostatic clustering and free energy calculations provide a foundation for protein design and optimization

Annals of Biomedical Engineering

Volumn 39, Issue 4, 2011, Pages 1252-1263

  Gorham Jr , Ronald D ^a   Kieslich, Chris A ^a   Morikis, Dimitrios ^a  

^a University of California Riverside   (United States)

Author keywords

Alanine scan; Continuum electrostatics; Electrostatic potential; Hierarchical clustering; Poisson Boltzmann equation; Solvation

Indexed keywords

ALANINE SCAN; CONTINUUM ELECTROSTATICS; ELECTROSTATIC POTENTIALS; HIER-ARCHICAL CLUSTERING; POISSON-BOLTZMANN EQUATIONS;

AMINO ACIDS; BINDING ENERGY; BOLTZMANN EQUATION; CLUSTER ANALYSIS; CLUSTERING ALGORITHMS; COMPLEXATION; DESIGN; DISSOCIATION; FREE ENERGY; MODEL STRUCTURES; OPTIMIZATION; POISSON EQUATION; PROTEINS; SOLVATION;

ELECTROSTATICS;

ALANINE; MUTANT PROTEIN; PROTEIN;

CHEMISTRY; DRUG DESIGN; GENETICS; METHODOLOGY; MUTAGENESIS; PH; PROTEIN ANALYSIS; PROTEIN ENGINEERING; REVIEW; STATIC ELECTRICITY; THERMODYNAMICS; VALIDATION STUDY;

ALANINE; DRUG DESIGN; HYDROGEN-ION CONCENTRATION; MUTAGENESIS; MUTANT PROTEINS; PROTEIN ENGINEERING; PROTEIN INTERACTION MAPPING; PROTEINS; STATIC ELECTRICITY; THERMODYNAMICS;

EID: 79954421528     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-010-0226-9     Document Type: Article

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