SCOPUS 정보 검색 플랫폼

Volumn 8, Issue 5, 2013, Pages 779-799

Synthesis and Structure-Activity Relationship Studies of Derivatives of the Dual Aromatase-Sulfatase Inhibitor 4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

(6) Woo, L W Lawrence a Wood, Paul M a Bubert, Christian a Thomas, Mark P a Purohit, Atul b Potter, Barry V L a

a University of Bath (United Kingdom)

b HAMMERSMITH HOSPITAL (United Kingdom)

Author keywords

Aromatase; Breast cancer; Dual inhibitors; Endocrine therapy; Steroid sulfatase

Indexed keywords

3 BROMO 4 [[(4 CYANOPHENYL)(4H 1,2,4 TRIAZOL 4 YL)AMINO]METHYL]PHENYL SULFAMATE; 3 CHLORO 4 [[(4 CYANOPHENYL)(4H 1,2,4 TRIAZOL 4 YL)AMINO]METHYL]PHENYL SULFAMATE; 3,5 DICHLORO 4 [[(4 CYANOPHENYL)(4H 1,2,4 TRIAZOL 4 YL)AMINO]METHYL]PHENYL SULFAMATE; 4 [2 [(4 CYANOPHENYL)(4H 1,2,4 TRIAZOL 4 YL)AMINO]ETHYL] 3,5 DIFLUOROPHENYL SULFAMATE; 4 [[(2,2 DIFLUOROBENZO[1,3]DIOXOL 5 YL)(4H 1,2,4 TRIAZOL 4 YL)AMINO]METHYL]PHENYL SULFAMATE; 4 [[(3,5 DIFLUOROPHENYL)(4H 1,2,4 TRIAZOL 4 YL)AMINO]METHYL]PHENYL SULFAMATE; 4 [[(4 CYANOPHENYL)(1H IMIDAZOL 1 YL)AMINO]METHYL] 3 FLUOROPHENYL SULFAMATE; 4 [[(4 CYANOPHENYL)(4H 1,2,4 TRIAZOL 4 YL)AMINO] 3 FLUOROPHENYL SULFAMATE; 4 [[(4 CYANOPHENYL)(4H 1,2,4 TRIAZOL 4 YL)AMINO]METHYL] 2 (DIFLUOROMETHYL)PHENYL SULFAMATE; 4 [[(4 CYANOPHENYL)(4H 1,2,4 TRIAZOL 4 YL)AMINO]METHYL] 2,3 DIFLUOROPHENYL SULFAMATE; 4 [[(4 CYANOPHENYL)(4H 1,2,4 TRIAZOL 4 YL)AMINO]METHYL] 3,5 DIFLUOROPHENYL SULFAMATE; 4 [[(4 CYANOPHENYL)(4H 1,2,4 TRIAZOL 4 YL)AMINO]METHYL]PHENYL SULFAMATE DERIVATIVE; 4 [[PHENYL(4H 1,2,4 TRIAZOL 4 YL)AMINO]METHYL]PHENYL SULFAMATE; 4 [N (4 CYANOPHENYL) N (4H 1,2,4 TRIAZOL 4 YL)FLUOROCARBONYL] PHENYL SULFAMATE; AROMATASE INHIBITOR; CARBENE; ESTERASE INHIBITOR; HALOGEN; IMIDAZOLE; LETROZOLE; STERYL SULFATASE; UNCLASSIFIED DRUG;

ARTICLE; ATOM; DEPROTECTION REACTION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGENATION; IC 50; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AROMATASE; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STERYL-SULFATASE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TRIAZOLES;

EID: 84877074103 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201300015 Document Type: Article

Times cited : (29)

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