Synthesis of aromatase inhibitors and dual aromatase steroid sulfatase inhibitors by linking an arylsulfamate motif to 4-(4H-1,2,4-triazol-4-ylamino) benzonitrile: SAR, crystal structures, in vitro and in vivo activities

ChemMedChem

Volumn 3, Issue 11, 2008, Pages 1708-1730

  Bubert, Christian ^a   Woo, L W Lawrence ^a   Sutcliffe, Oliver B ^a   Mahon, Mary F ^b   Chander, Surinder K ^c   Purohit, Atul ^c   Reed, Michael J ^c   Potter, Barry V L ^a  

^a UNIVERSITY OF BATH   (United Kingdom)

^b University of Bath Claverton Down   (United Kingdom)

^c ST MARY S HOSPITAL   (United Kingdom)

Author keywords

Aromatase inhibitors; Breast cancer; Dual aromatase sulfatase inhibitors; Endocrine therapy; Sulfatase inhibitors

Indexed keywords

4 (4H 1,2,4 TRIAZOL 4 YLAMINO)BENZONITRILE; 4-(4H-1,2,4-TRIAZOL-4-YLAMINO)BENZONITRILE; AROMATASE; AROMATASE INHIBITOR; BENZONITRILE; ESTRADIOL; NITRILE; STERYL SULFATASE; SULFONAMIDE; TRIAZOLE DERIVATIVE;

ARTICLE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; IC 50; IN VITRO STUDY; METABOLISM; METHODOLOGY; PROTEIN MOTIF; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

AMINO ACID MOTIFS; AROMATASE; AROMATASE INHIBITORS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ESTRADIOL; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR CONFORMATION; NITRILES; STERYL-SULFATASE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TRIAZOLES;

EID: 55949137671     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800164     Document Type: Article

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